Piroxicam Powder CAS 36322-90-4

Piroxicam powder is a needle shaped crystalline substance with a white or slightly yellow green color, with a melting point of 198-200 ℃, odorless, and tasteless. Almost insoluble in water, slightly soluble in ethanol or ether, easily soluble in chloroform, alkali, and pyridine, slightly soluble in acetone, soluble in acid solution.

What are the pharmacological effects of piroxicam?

Piroxicam is a long-acting anti-inflammatory, analgesic, and antipyretic product of the benzothiazine class, which has a strong inhibitory effect on the synthesis of PG synthase in the body, thereby reducing the synthesis of local prostaglandins in tissues. In addition, inhibiting cyclooxygenase can also suppress the chemotaxis of white blood cells (white blood cells moving towards inflammatory areas) and the outward release of lysosomal enzymes. Therefore, this product has strong antipyretic, analgesic, anti-inflammatory, anti rheumatic effects and a certain degree of anti-inflammatory effect.

Pure Piroxicam powder can be quickly and completely absorbed in the body, and food can slow down the absorption rate without affecting the total absorption. Tmax 3-5 hours. T1/2 is 30-86 hours, PPB is greater than 90%, and T1/2 is prolonged in patients with renal insufficiency, mainly through liver metabolism. However, it should be noted that due to the long T1/2 ratio, a single administration can maintain a relatively stable blood drug concentration for 24 hours. Therefore, it is not recommended to use the product multiple times in a short period of time, as this can easily lead to product accumulation and pose a threat to physical safety. The effective concentration of the blood drug is 1.5-2 μ g/ml. The stable blood drug concentration can only be reached 7-12 days after the start of treatment. 66% is excreted through the kidneys, 33% through feces, and<5% is in its original form.

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