Rosuvastatin calcium powder is an HMG-CoA reductase inhibitor, which was developed by AstraZeneca, UK, and is suitable for the treatment of various lipid abnormalities, including hypercholesterolemia, mixed lipid abnormalities and simple hypertriglyceridemia. Although atorvastatin is recognized by the world medical community as having the best curative effect at present, it has a better effect on lowering Low density lipoprotein cholesterol and increasing high-density lipoprotein than atorvastatin in the minds of users.
Product Specification
| Item | Specification | Results |
| Description | White to beige powder | Confirm |
| Purity (HPLC) | ≥98.0% | 98.8% |
| Acetate content | ≤5.0% | 2.38% |
| Identification | IR | Confirm |
| Related compounds | Any impurity ≤0.2% | 0.03% |
| Total impurities≤0.5% | 0.01% | |
| Water | ≤5.0% | 3.11% |
| Loss on drying | ≤3.0% | 2.21% |
| Heavy metal | ≤10ppm | 0.23ppm |
| Conclusion | Conforms with enterprise standards |
What is HMG-CoA reductase inhibitor?
Rosuvastatin calcium is the statins with the strongest lipid-lowering effect and the most comprehensive lipid-regulating effect among the currently listed lipid-lowering products, and statins are another name of HMGCoA reductase inhibitor, which is the rate-limiting enzyme that transforms 3- hydroxy -3- methylglutaryl CoA into methyl valerate, the precursor of cholesterol.
|
We know that mevalonic acid (MVA) will be produced in the process of cholesterol synthesis in organisms. According to the research of modern biochemistry, it is found that in the process of producing MVA, the whole biochemical process can only be completed under the catalysis of HMG-COA reductase (HMGCR), And the substrate for the reaction must be HMG-CoA. Therefore, if we want to prevent the synthesis of new cholesterol substances, it is simple and necessary to destroy the catalyst and substrate in the MVA synthesis process, and then destroy the new MVA (the first red font mark in the figure). It is in this destruction process that HMGCoA reductase inhibitor, represented by Rosuvastatin, achieves its goal by inhibiting the efficiency of catalyst HMGCR, Thus reducing the further synthesis of cholesterol, lowering the cholesterol concentration in serum, tissues, and cells, and achieving the ultimate goal of regulating blood lipids. |
|
FTF provides you with affordable but high-quality HMG CoA reductase inhibitors (statins)
Statins reduce the levels of low-density lipoprotein (LDL) cholesterol and total cholesterol by inhibiting the rate-limiting enzyme (HMG-CoA) reductase.Its regular products are as follows:
 |
 |
 |
|
Lovastatin 75330-75-5 Mevastatin 73573-88-3 |
Atorvastatin Calcium Salt Trihydrate 134523-03-8 | Fluvastatin SodiuM Salt Hydrate 93957-55-2 |
|
|
|
|
| Pravastatin Sodium 81131-70-6 | Rosuvastatin Calcium 147098-20-2 | Simvastatin 79902-63-9 |
As a new scientific research company, our company can provide a variety of statins with favorable prices for your scientific research, such as Rosuvastatin Calcium 147098-20-2, Lovastatin 75330-75-5 and so on in the above table. If you are interested in related research, please contact us by email: sales6@faithfulbio.com.
Can rosuvastatin calcium 20mg be taken for a long time?
As a commonly used statin lipid-lowering product in clinic, the general specification of rosuvastatin calcium powder is 5mg or 10mg, but when it is used, the effect is often not obvious, so it needs to be adjusted to a higher specification of 20mg. In the meantime, we need to pay attention to the dose difference between 10mg and 20mg mainly lies in the drug concentration and efficacy strength in the body.
However, according to relevant statistics, the dosage is rarely increased in clinic, and other products will basically be considered for replacement, because according to data comparison, it is found that the lipid-lowering effect of high-intensity statins (referring to the use of 20mg dose of rosuvastatin) can only be increased by 6%, but the risk of adverse reactions and side effects is relatively increased. For example, it will cause transient increase of liver transaminase and abnormal liver function, and rhabdomyolysis may also cause muscle pain.
Therefore, high dose may bring stronger lipid-lowering effect, but short-term use will lead to the risk of sudden increase of some side effects, and long-term use will definitely accumulate some side effects, which will inevitably bring destructive effects to the body.
In addition, the pharmacological basis of statins is basically similar, so we need to pay attention to avoid combining with powerful statins in order to avoid drug interaction and unintended consequences.
A variety of shipping methods for you to choose
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China, Therefore, we can not only provide customers with the required Rosuvastatin Calcium powder, but also offer the production and research of other statin raw materials.
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.
Disclaimer: The information published on this website comes from the internet, which does not mean that this website agrees with its views or confirms the authenticity of the content. Please pay attention to distinguish it. In addition, the products provided by our company are only used for scientific research. We are not responsible for the consequences of any improper use.
If you are interested in our products, or have critical suggestions on our articles or are not completely satisfied with the products received, please contact us by Email ：sales6@faithfulbio.com . Our team is committed to ensuring the complete satisfaction of customers.
Hot Tags: rosuvastatin calcium powder cas 147098-20-2, China, suppliers, manufacturers, factory, customized, wholesale, buy, price, bulk, pure, producer, discount, for sale, in stock, free sample, raw powder, raw material, made in China