Ginsenoside Rb1 CAS 41753-43-9
Product Name:Ginsenoside Rb1
CAS NO.: 41753-43-9
Molecular Formula:C54H92O23
EINECS.NO:255-532-8
Synonym:Ginsenoside-Rb1;ginsinoside Rb1;Gypenoside III;Ginsenoside Rb1;arasaponine1
Shipping:DHL,Germany DHL,Germany DPD,UPS,USPS,FedEx,EMS,By Air,By Sea etc
Store & Shelf life:Cool & dry place;36 months
Other:There are warehouses in the United States, Australia and Germany
Description
what is Ginsenoside Rb1?
Ginsenoside Rb1 is a ginsenoside of the panaxadiol series, belonging to the dammarane type triterpenoid saponin compounds. It is mainly distributed in plants such as Panax ginseng, Panax notoginseng, and Panax ginseng in the Araliaceae family, and is currently a hot research topic. White amorphous powder or colorless crystal, slightly sweet and bitter in taste, hygroscopic, generally unstable to acid, can be hydrolyzed under weak acid, but the true original form of sapogenin cannot be obtained after hydrolysis.
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Product name |
Ginsenoside Rb1 |
|
CAS |
41753-43-9 |
|
|
Molecular formula |
C54H92O23 | |
|
Molecular weight |
1109.29 | |
| EINECS | 255-532-8 | |
|
Appearance |
white powder |
|
| Melting point | 197.5°C | |
| Density | 1.0971 (rough estimate) |
what is the main effect of Ginsenoside Rb1?
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Anti-aging: Studies indicate that ginsenoside Rb1 can alleviate body aging caused by stress, potentially by restoring hormone levels and influencing the expression of hyaluronic acid synthase 2 (HAS2), which is important for skin hydration. Antioxidant: Rb1 can scavenge reactive oxygen species (ROS) and protect against oxidative damage to biomacromolecules. Anti-inflammatory: Rb1 has been shown to inhibit inflammatory pathways and reduce inflammation in various contexts. Neuroprotective: It has shown potential in protecting nerve cells from damage and promoting neuronal survival. |
Cardiovascular Effects:
Rb1 has been shown to have protective effects on the heart, including reducing myocardial infarct size and improving cardiac function.
Potential Drug Interactions:
Ginsenoside Rb1 may interact with other drugs by acting as a transporter, influencing their absorption and distribution in the body.
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Product Specification
| Items | Specifications |
Result |
|
Appearance |
white powder |
White powder |
|
Partical size |
100% through 80mesh |
Conforms |
|
Assay(hplc) |
≥98% |
98.6% |
|
Loss on drying |
≤5% |
3.2% |
|
Moisture content |
≤5% |
2.6% |
|
Heavy metals |
≤10ppm |
Conforms |
|
Arsenic |
≤2.0ppm |
Conforms |
|
Cadmium |
≤2.0ppm |
Conforms |
|
Lead |
≤5.0ppm |
Conforms |
|
Mercury |
≤1.0ppm |
Conforms |
What are the pharmacological effects of Ginsenoside Rb1?
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A 1998 study reported that GRb1 and GRg3 (ginsenosides Rb1 and Rg3) significantly attenuated glutamate-induced neurotoxicity by inhibiting the overproduction of nitric oxide synthase among some other findings regarding their neuroprotective properties. In 2002,a study showed that GRb1 and GRg1 have neuroprotective effect for spinal cord neurons, while ginsenoside Re did not exhibit any activity. GRb1 and GRg1 are proposed to represent potentially effective therapeutic agents for spinal cord injuries. |
The protection that GRg1 (ginsenoside Rg1) and GRb1 offer against Alzheimer's disease symptoms in mice was first published by researchers in 2015. The GRg1 affected three metabolic pathways: the metabolism of lecithin, amino acids and sphingolipids, while GRb1 treatment affected lecithin and amino acid metabolism.
It was reported in 2017 that GRb1 improved cardiac function and remodelling in heart failure in mice. The treatment of H-ginsenoside Rb1 potentially attenuated cardiac hypertrophy and myocardial fibrosis
How to synthesize Ginsenoside Rb1?
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The biosynthesis of Ginsenoside Rb1 in Panax ginseng starts from farnesyl diphosphate (FPP), which is converted to squalene with squalene synthase (SQS), then to 2,3-oxidosqualene with squalene epoxidase (SE). The 2,3-oxidasqualene is then converted to dammarenediol-II by cyclization, with dammarenediol-II synthase (DS) as the catalyst. The dammarenediol-II is converted to protopanaxadiol and then to ginsenoside Rd. Finally, GRb1 is synthesized from ginsenoside Rd, catalysed by UDPG:ginsenoside Rd glucosyltransferase (UGRdGT) |
How and where to buy Ginsenoside Rb1?
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A variety of shipping methods for you to choose
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL, Germany DHL, Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
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Note: The product is for research use only and is not intended for diagnosis, treatment, disease prevention, etc.
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