Alogliptin Benzoate Powder CAS 850649-62-6

Alogliptin benzoate powder, also known as Alogliptin, was officially listed in China in early 2014, and it was the first batch of drugs approved by China for the treatment of type 2 diabetes with proven cardiovascular safety data. Following the introduction of Sitagliptin and Vildagliptin, Alogliptin and its pharmaceutical composition are new, effective and specific serine protease dipeptidyl peptidase ⅳ (DPP-ⅳ) inhibitors developed by Takeda Company in Japan. It provides a new and important treatment choice for patients with type 2 diabetes, and has a wide application prospect at present.

What is DPP-4 inhibitor?

DPP-4 is a serine protease on the cell surface. The highest expression of DPP-4 is in the intestine, and it is also expressed in the liver, pancreas, placenta and thymus. DPP-4 can inactivate many bioactive peptides, including GLP-1 and GIP. DPP-4 inhibitor, namely dipeptidyl peptidase 4 inhibitor, can inactivate DPP-4, so as not to decompose GLP-1 and GIP. By increasing the levels of endogenous GLP-1 and GIP, it can promote the release of insulin from islet β cells and inhibit the secretion of glucagon from islet α cells, and finally achieve the effect of controlling blood sugar. This method can not only reduce blood sugar, but also not easily induce hypoglycemia and gain weight. It is also one of the main directions of drug research for treating diabetes at present.
DPP-4 inhibitors currently used in the market mainly include Sitagliptin, Saxagliptin, Vildagliptin, Linagliptin and ALOGLIPTIN. Experiments show that DPP-4 inhibitor alone can reduce glycosylated hemoglobin by 0.4%-1.0%, and the effect is better if it is combined with oral hypoglycemic drugs and insulin commonly used in clinic.In the production of blood sugar lowering products, our company has always adhered to a diligent and simple style. Products such as Alogliptin benzoate and Trelagliptin Succinate have a large inventory in our company. If you are interested, please contact us via email:sales6@faithfulbio.com.

Can DPP-4 enzyme inhibitors be used for a long time?

Alogliptin benzoate powder is a common hypoglycemic product in DPP-4 enzyme inhibitor. Taking this product as an example, we learned from the above that an appropriate amount of Alogliptin benzoate can help increase the concentration of incretin in the body by inhibiting DPP-4 enzyme in the body. Enterokinesin can first regulate islet β cells and make islet β cells secrete insulin after eating. In addition, it can not only reduce the level of glucagon, but also act on the center, so that patients' appetite for food is reduced; It acts on the gastrointestinal tract, making the gastrointestinal tract feel full after eating and reducing the desire for food. Therefore, during normal use, the blood sugar not only drops to the ideal state, but also has little influence on the patient's weight, and there are few reports of hypoglycemia.
However, some customers will use this product privately because of weight loss troubles, and most of them will use it for a long time. However, this will not only increase the workload of renal function, lead to abnormal metabolism of food and drugs, but also lead to hypoglycemia due to abnormal blood sugar control system.
If you have a long-term high dose of Alogliptin benzoate, which leads to adverse reactions such as decreased blood sugar, confusion and coma, you need to stop taking the drug in time. After stopping taking the drug, the adverse reactions will subside without special treatment. If it is a problem such as renal failure, go to the hospital for treatment as soon as possible.

What are the side effects of dipeptidyl peptidase -4(DPP-4) inhibitors?

DPP-4 inhibitors have certain advantages in the treatment of type 2 diabetes. However, there may be adverse reactions such as gastrointestinal reactions, infections, skin reactions, and liver function damage.
1. Gastrointestinal reactions: Common gastrointestinal reactions include nausea, vomiting, and diarrhea. These reactions usually have a short duration and an incidence rate of about 3%. Gradually increasing the dosage can reduce the occurrence of gastrointestinal reactions.
2. Infection: The use of DPP-4 inhibitors may increase the risk of nasopharyngitis, urinary tract infections, and upper respiratory tract infections. There are also studies indicating that the use of DPP-4 inhibitors increases the incidence of nephritis and cystitis.
3. Skin reactions: Some DPP-4 inhibitors may cause adverse skin reactions such as dryness, allergic reactions, contact dermatitis, and rash, which are more common within the first 3 months of medication.
4. Liver function impairment: DPP-4 inhibitors may lead to elevated liver transaminases. There have been reports of cases where improper use of alogliptin benzoate resulted in significant increases in bilirubin and total bilirubin.
In addition, this type of medication may also cause acute pancreatitis, renal dysfunction, hypoglycemia, etc., and strict adherence to medication guidelines is required when using it.

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Our strengths:

Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China, Our company is committed to developing more DPP-4 enzyme inhibitor products, such as Sitagliptin, Saxagliptin, Vildagliptin, Linagliptin and ALOGLIPTIN. If you have any needs or interests in this field, please contact us

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