Procaine hydrochloride is a local anesthetic, which can temporarily block the conduction of nerve fibers and has an anesthetic effect. It has a strong effect, low toxicity, and no addiction. However, it has weak penetration to skin and mucous membrane and is not suitable for surface anesthesia. Clinically, it is mainly used for infiltration, spinal cord, and conduction anesthesia.
How should I take the medicine?
Because of anesthetic, procaine hydrochloride must be prescribed by the doctor according to the patient's condition and used according to the doctor's instructions, including usage, dosage, medication time, etc. Do not use drugs according to the drug instructions without authorization.
Before use, an intradermal sensitivity test must be performed. In case of a large red halo around, care should be taken. The drug must be administered several times. Those with swelling should be observed for a long time, each time no more than 30 ~ 50 mg. When it is proved that there is no adverse reaction, the drug can be continued to be administered; Those with obvious swelling complain of discomfort and stop taking the medicine immediately.
Do not wash and disinfect medical products with alkaline substances such as soap and coal phenol soap solution. Keep away from iodine, otherwise, procaine will precipitate.
Take a rest of more than 1 hour after giving the maximum dose. It cannot penetrate into the skin and mucous membrane and is invalid for external use.
Except for special reasons, it is generally unnecessary to add adrenaline. If it is necessary to add adrenaline, it should be added at the time of clinical use, and patients with hypertension should be cautious.
The liquid medicine can not be directly used in the blood. During the administration, it should be pumped repeatedly without blood return.
The characteristics and use of this product should be administered in strict accordance with this manual. Malnutrition and starvation are more prone to toxic reactions and should be reduced.
During spinal anesthesia, it is especially necessary to adjust the block plane and observe the changes in blood pressure and pulse at any time.
Can procaine hydrochloride be used during pregnancy and lactation?
According to the standards issued by the FDA, procaine hydrochloride belongs to pregnancy safety class C: there are adverse results in animal reproductive studies, but no appropriate control group studies have been conducted in humans. These drugs can be used only after weighing the benefits to pregnant women over the harm to the fetus.
Pregnant women should weigh the advantages and disadvantages and use it when the advantages outweigh the disadvantages; Breastfeeding women should use it with caution. If necessary, breastfeeding should be suspended.
How to verify and configure this product?
To verify the authenticity of this product, first of all, we can start with the basic properties. At room temperature, it is white fine needle crystal or crystalline powder, odorless, slightly bitter and numb, easily soluble in water, soluble in ethanol, slightly soluble in chloroform, and almost insoluble in ether. If you are still worried, you can contact a professional research institution. Do not experiment privately to avoid accidents. (the ester bond in the structure of procaine hydrochloride can be hydrolyzed to produce p-aminobenzoic acid and dimethylaminoethanol. Under certain conditions, p-aminobenzoic acid can be further decarboxylated to produce toxic aniline.) Procaine hydrochloride has an aromatic primary amino group in its structure, which is easy to oxidize and change color. PH value, temperature, ultraviolet light, oxygen, and metal ions can accelerate the oxidation and change color.
When preparing this product, attention should be paid to controlling the aqueous solution between pH3.0 and 5.0, which has little impact on the properties of this product. Therefore, when preparing procaine hydrochloride solution, it is generally necessary to add acid to adjust the pH between 3.3 and 5.5, and strictly control the sterilization temperature and time. It is appropriate to sterilize with circulating steam at 100 ℃ for 30min, and pay attention to shading and sealed storage. The aromatic primary amino group in the structure of this product will form diazonium salt with sodium nitrite in dilute hydrochloric acid, and add alkali β- Naphthol is coupled to produce scarlet azo compounds.