what is 6-Diazo-5-oxo-L-norleucine powder?
6-Diazo-5-oxo-L-nurleucine powder , abbreviated as DON, CAS number: 157-03-9, molecular formula: C₆H₉N₃O₃, molecular weight: 171.15, appearance is a light yellow crystalline powder, texture is crystalline, and has good fluidity. Derived from microbial metabolism or chemical synthesis such as Streptomyces. It is a Boc-D-Glutamine antagonist that mainly blocks the nutrient utilization of rapidly proliferating cells such as tumor cells by inhibiting key enzymes in Boc-D-Glutamine metabolism. Therefore, it is mainly used in tumor treatment research, biochemical mechanism research, and antibacterial and antiviral fields; At the same time, it is also an important mother nucleus for developing hypoxic activation prodrugs.
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Product name |
6-Diazo-5-oxo-L-norleucine |
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CAS |
157-03-9 |
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Molecular formula |
C6H9N3O3 | |
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Molecular weight |
171.15 | |
| EINECS | 251-228-4 | |
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Appearance |
light yellow powder |
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| Melting point | 145 °C | |
| Desity |
1.3994 (rough estimate) |
What are the HISTORY of 6-Diazo-5-oxo-L-norleucine powder?
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6-Diazo-5-oxo-L-norleucine powder is a glutamine antagonist, which was isolated originally from Streptomyces in a sample of Peruvian soil. This diazo compound is biosynthesized from lysine by three enzymes in bacteria. It is one of the most famous non-proteinogenic amino acid and was characterized in 1956 by reserchers.who suggested a possible use in cancer therapy. This antitumoral efficacy was confirmed in different animal models. DON was tested as chemotherapeutic agent in different clinical studies, but was never approved. In 2019, DON was shown to kill tumor cells while reversing disease symptoms and improve over all survival in late-stage experimental glioblastoma in mice, when combined with calorie-restricted ketogenic diet. |
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What are the studies of 6-Diazo-5-oxo-L-norleucine powder?
In vitro
6-Diazo-5-oxo-L-norleucine appears to be positive in the in vitro chromosome aberration assay that it demonstrates dose dependent statistically positive increase in structural aberrations at 4 and 20 hour exposure without S9 and also at 4 hour exposure with S9.
In vivo
6-Diazo-5-oxo-L-norleucine powder is evaluated for its in vivo clastogenic activity by detecting micronuclei in polychromatic erythrocyte (PCE) cells in bone marrow collected from the male mice dosed intravenously with 500, 100, 10, 1 and 0.1 mg/kg at 24 and 48 hour post dose. The in vivo micronucleus assay reveals a statistically positive response for micronucleus formation at 500, 100 and 10 mg/kg at 24 and 48 hour post dose.
Product Specification
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Items |
Specifications |
Results |
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Appearance |
light yellow crystalline powder |
Conforms |
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Identification |
complies |
complies |
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Assay |
≧98.0 |
98.45% |
Conclusion：Conform with specification and qualified.
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What are the targets of 6-Diazo-5-oxo-L-norleucine powder?
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6-Diazo-5-oxo-L-norleucine powder is used as inhibitor of different glutamine utilizing enzymes. Due to its similarity to glutamine, it can enter catalytic centres of these enzymes and inhibits them by covalent binding, or more precisely, by alkylation.The following table gives a survey of DON targets |
Why choose us?
Our DON comes from a well-known factory in China, with excellent product quality and high customer repurchase rate.
We have rich experience in cross-border transportation and multi-channel transportation to ensure the safe arrival of products.
The minimum order quantity is flexible, ranging from 100mg to 10g, and we can provide assistance for your scientific research and production.
A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL, Germany DHL, Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
FAQ
Q1:How is DON's solubility?
A1:DON is easily soluble in water, as well as in physiological saline and phosphate buffered saline (PBS).
Q2:Do we need to transport and store in the dark?
A2:DON is prone to decomposition at room temperature or under light exposure and needs to be sealed and stored away from light.
Q3:What signaling pathways or enzymes does Don mainly act on?
A3:Mainly irreversibly inhibits glutaminase (GLS) and phosphoribosyl pyrophosphate transaminase (PPAT), thereby blocking Boc-D-Glutamine catabolism and purine/pyrimidine synthesis.
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Note: The product is for research use only and is not intended for diagnosis, treatment, disease prevention, etc.
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