what is micronized progesterone powder?
Progesterone (CAS: 57-83-0, molecular formula C21H30O2, molecular weight 314.46) is a white to off white fine crystalline powder, naturally derived from animal ovarian corpus luteum, and now mostly synthesized and fermented from plant sterols; This substance belongs to steroid progestogens, which can regulate female endocrine, maintain pregnancy, regulate menstruation, promote breast development, and balance body hormones. Currently, it is widely used in the fields of medicine, veterinary medicine, biological research, and related health and skincare.Micronized Progesterone Powder has two crystal forms, namely α - type and β - type, which have the same physiological activity. The α - type is an orthorhombic white prismatic crystal, and the β - type is an orthorhombic white needle shaped crystal, both of which are insoluble in water.
 | Product name | progesterone |
| CAS | 57-83-0 | |
| Molecular formula | C21H30O2 | |
| Molecular weight | 314.46 | |
| EINECS | 200-350-6 | |
| Appearance | white powder | |
| Melting point | 128-132 °C (lit.) | |
| Density | d23 1.166; d20 1.171 |
What are the uses of micronized progesterone powder?
| 1. Progesterone can maintain pregnancy in female animals and cause a series of physiological changes in pregnant animals, such as inhibiting female estrus. 2. Promote thickening of the uterine mucosal layer, increase in glandular curvature, and enhancement of secretion function. 3. Inhibit uterine peristalsis, cause cervical contractions, and secrete viscous fluids. These physiological changes provide suitable environmental conditions for the operation, growth and development, implantation of early embryos, and the continued growth of fetuses after implantation. |
4. A small amount of progesterone synergizes with estrogen to promote estrus in female animals. Progesterone and prolactin work together to promote the development of breast glands.
5. Progesterone participates in the feedback regulation of the hypothalamus and anterior pituitary gland, coordinating and balancing the secretion of reproductive hormones in animals.
micronized progesterone powder can be used for habitual miscarriage, threatened miscarriage, functional uterine bleeding, blood clots, dysmenorrhea, endometriosis, amenorrhea, and ureteral stones. Benign prostatic hyperplasia, sleep apnea syndrome, and refractory liver cirrhosis ascites, etc
Product Specification
| Items | Specifications | Result |
| Assay (on the dried basis ) | 97.0%~103.0% | 99.40% |
| Characters | White or creamy white crystalline powder | White crystalline powder Micronized |
| Identification | ||
| Infrared absoption (197K) | The IR spectrum of sample,exhibits maxima only at the same wavelength as that a similar preparation of USP Progesterone RS | Complies |
| Ultraviolet absorption (197U) | The UV absorption spectra of the test solution and the standard solution exhibit maxima at the same wavelengths | Complies |
| Melting range(741) | Between 126°C and 131°C | 129~131°C |
| Specific rotation(781S) | Between +175°C and +183°C | +179°C |
| Loss on drying (731) | 0.5% Max | 0.22% |
| Any impurity: 0.5% max | 0.31% | |
| Total impurities: 0.8% max | 0.50% | |
| Methanol: 500ppm max | Not detected | |
| Related Substances | Ethanol: 2000ppm max | 339ppm |
| Toluene: 300ppm max | Not detected | |
| Cyclohexanone: 50ppm max | Not detected | |
| Particle size | 90% pass20μm | Complies |
Conclusion：Conform with specification and qualified.
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How micronized progesterone powder is biosynthesized in vivo?
In mammals, progesterone, like all other steroid hormones, is synthesized from pregnenolone, which itself is derived from cholesterol.
Cholesterol undergoes double oxidation to produce 22R-hydroxycholesterol and then 20α,22R-dihydroxycholesterol. This vicinal diol is then further oxidized with loss of the side chain starting at position C22 to produce pregnenolone. This reaction is catalyzed by cytochrome P450scc.
| The conversion of pregnenolone to progesterone takes place in two steps. First, the 3β-hydroxyl group is oxidized to a keto group and second, the double bond is moved to C4, from C5 through a keto/enol tautomerization reaction.This reaction is catalyzed by 3β-hydroxysteroid dehydrogenase/δ5-4-isomerase. micronized progesterone powder in turn is the precursor of the mineralocorticoid aldosterone, and after conversion to 17α-hydroxyprogesterone, of androstenedione. Androstenedione can be converted to estrone, and estradiol |
what is the total synthesis of micronized progesterone powder?
| The synthesis begins with reacting the phosphonium salt 7 with phenyl lithium to produce the phosphonium ylide 8. The ylide 8 is reacted with an aldehyde to produce the alkene 9. The ketal protecting groups of 9 are hydrolyzed to produce the diketone 10, which in turn is cyclized to form the cyclopentenone 11. The ketone of 11 is reacted with methyl lithium to yield the tertiary alcohol 12, which in turn is treated with acid to produce the tertiary cation 13. The key step of the synthesis is the π-cation cyclization of 13 in which the B-, C-, and D-rings of the steroid are simultaneously formed to produce 14. This step resembles the cationic cyclization reaction used in the biosynthesis of steroids and hence is referred to as biomimetic. In the next step the enol orthoester is hydrolyzed to produce the ketone 15. The cyclopentene A-ring is then opened by oxidizing with ozone to produce 16. Finally, the diketone 17 undergoes an intramolecular aldol condensation by treating with aqueous potassium hydroxide to produce micronized progesterone powder. |
Company profile
A variety of shipping methods for you to choose
| Transportation Time | Shipping method | Cargo weight requirements | Advantage |
| 3-7 days | DHL, Germany DHL, Germany DPD, UPS, USPS,FedEx, TNT,EMS | Suitable for under 50kg. International door to door express | We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
| 7-15 days | By Air | Suitable for more than 50kg. fast and cheaper for large order | |
| 15-60 days | By Sea | Suitable for more than 500kg. Cheapest shipping way |
FAQ
Q1:How to store the package after receiving it?
A1:It should be sealed and stored in a cool, dry, and dark place, away from high temperatures and humid environments.
Q2:What are the signs of low progesterone?
A2:Irregular menstrual periods.Headaches.Difficulty conceiving.Mood changes, anxiety or depression.Trouble sleeping.Hot flashes.Bloating or weight gain.
Q3:Do you have regular particle size progesterone?
A3:Yes, we can provide micro powder or regular powder.
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Note: The product is for research use only and is not intended for diagnosis, treatment, disease prevention, etc.
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