Micronized Progesterone Powder CAS 57-83-0
Product Name:micronized progesterone powder
CAS NO.:57-83-0
Molecular Formula:C21H30O2
EINECS.NO:200-350-6
Synonym:3,20-pregnene-4;4-pregnene-3,20-dione;beta-progesterone;corlutin;corlutina;corluvite
Shipping:DHL,Germany DHL,Germany DPD,UPS,USPS,FedEx,EMS,By Air,By Sea etc
Store & Shelf life:Cool & dry place;36 months
Other:There are warehouses in the United States, Australia and Germany
Description
what is micronized progesterone powder?
Progesterone, abbreviated as P4, also known as Pregnancy-4-ene-3,20-dione, is an endogenous steroid and progesterone hormone, and the main progestin in the body, secreted by the ovaries of women. Progesterone is a steroid hormone containing 21 carbon atoms secreted by ovarian corpus luteum cells. It is also an intermediate product in the synthesis of all steroid hormones, it is a type of estrogen. Micronized Progesterone Powder has two crystal forms, namely α - type and β - type, which have the same physiological activity. The α - type is an orthorhombic white prismatic crystal, and the β - type is an orthorhombic white needle shaped crystal, both of which are insoluble in water.
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Product name |
progesterone |
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CAS |
57-83-0 | |
|
Molecular formula |
C21H30O2 |
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|
Molecular weight |
314.46 | |
| EINECS | 200-350-6 | |
|
Appearance |
white powder |
|
| Melting point | 128-132 °C (lit.) | |
| Density | d23 1.166; d20 1.171 |
What are the physiological functions and uses of micronized progesterone powder?
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1. Progesterone can maintain pregnancy in female animals and cause a series of physiological changes in pregnant animals, such as inhibiting female estrus. 2. Promote thickening of the uterine mucosal layer, increase in glandular curvature, and enhancement of secretion function. 3. Inhibit uterine peristalsis, cause cervical contractions, and secrete viscous fluids. These physiological changes provide suitable environmental conditions for the operation, growth and development, implantation of early embryos, and the continued growth of fetuses after implantation. .If you need it, pls click e-mail sales1@faithfulbio.com |
4. A small amount of progesterone synergizes with estrogen to promote estrus in female animals. Progesterone and prolactin work together to promote the development of breast glands.
5. Progesterone participates in the feedback regulation of the hypothalamus and anterior pituitary gland, coordinating and balancing the secretion of reproductive hormones in animals.
micronized progesterone powder can be used for habitual miscarriage, threatened miscarriage, functional uterine bleeding, blood clots, dysmenorrhea, endometriosis, amenorrhea, and ureteral stones. Benign prostatic hyperplasia, sleep apnea syndrome, and refractory liver cirrhosis ascites, etc
Product Specification
| Items | Specifications |
Result |
|
Assay (on the dried basis ) |
97.0%~103.0% |
99.40% |
|
Characters |
White or creamy white crystalline powder |
White crystalline powder Micronized |
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Identification |
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|
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Infrared absoption (197K) |
The IR spectrum of sample,exhibits maxima only at the same wavelength as that a similar preparation of USP Progesterone RS |
Complies |
|
Ultraviolet absorption (197U) |
The UV absorption spectra of the test solution and the standard solution exhibit maxima at the same wavelengths |
Complies |
|
Melting range(741) |
Between 126°C and 131°C |
129~131°C |
|
Specific rotation(781S) |
Between +175°C and +183°C |
+179°C |
|
Loss on drying (731) |
0.5% Max |
0.22% |
|
|
Any impurity: 0.5% max |
0.31% |
|
|
Total impurities: 0.8% max |
0.50% |
|
|
Methanol: 500ppm max |
Not detected |
| Related Substances |
Ethanol: 2000ppm max |
339ppm |
|
Toluene: 300ppm max |
Not detected |
|
|
Cyclohexanone: 50ppm max |
Not detected |
|
| Particle size |
90% pass20μm |
Complies |
How micronized progesterone powder is biosynthesized in vivo?
In mammals, progesterone, like all other steroid hormones, is synthesized from pregnenolone, which itself is derived from cholesterol.
Cholesterol undergoes double oxidation to produce 22R-hydroxycholesterol and then 20α,22R-dihydroxycholesterol. This vicinal diol is then further oxidized with loss of the side chain starting at position C22 to produce pregnenolone. This reaction is catalyzed by cytochrome P450scc.
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The conversion of pregnenolone to progesterone takes place in two steps. First, the 3β-hydroxyl group is oxidized to a keto group and second, the double bond is moved to C4, from C5 through a keto/enol tautomerization reaction.This reaction is catalyzed by 3β-hydroxysteroid dehydrogenase/δ5-4-isomerase. micronized progesterone powder in turn is the precursor of the mineralocorticoid aldosterone, and after conversion to 17α-hydroxyprogesterone, of androstenedione. Androstenedione can be converted to estrone, and estradiol |
what is the total synthesis of micronized progesterone powder?
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The synthesis begins with reacting the phosphonium salt 7 with phenyl lithium to produce the phosphonium ylide 8. The ylide 8 is reacted with an aldehyde to produce the alkene 9. The ketal protecting groups of 9 are hydrolyzed to produce the diketone 10, which in turn is cyclized to form the cyclopentenone 11. The ketone of 11 is reacted with methyl lithium to yield the tertiary alcohol 12, which in turn is treated with acid to produce the tertiary cation 13. The key step of the synthesis is the π-cation cyclization of 13 in which the B-, C-, and D-rings of the steroid are simultaneously formed to produce 14. This step resembles the cationic cyclization reaction used in the biosynthesis of steroids and hence is referred to as biomimetic. In the next step the enol orthoester is hydrolyzed to produce the ketone 15. The cyclopentene A-ring is then opened by oxidizing with ozone to produce 16. Finally, the diketone 17 undergoes an intramolecular aldol condensation by treating with aqueous potassium hydroxide to produce micronized progesterone powder. |
How and where to buy micronized progesterone powder?
We have 8 years of experience in selling legal scientific research drugs and have a good reputation, making us a trustworthy partner.
We ensure the quality of our products through independent experimental testing, and every customer is our VIP.
Send your Inquiry for more information, Click email：sales1@faithfulbio.comNow.
A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL, Germany DHL, Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
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Note: The product is for research use only and is not intended for diagnosis, treatment, disease prevention, etc.
Send your Inquiry for more details, Click email：sales1@faithfulbio.com Now.
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