What is estriol ?
Estriol is a natural hormone and a metabolite of estradiol in the body, which mainly exists in urine. Estrogen is less active, about 6 times as active as estrone, but weaker than estradiol and has no carcinogenic effect. estriol bulk powder has a selective effect on vagina and cervical canal, but has no effect on uterine entity and endometrium.
estriol bulk is a white powder. Mp283℃; The relative density is 1.27; Estriol powder is insoluble in water and slightly soluble in vegetable oil.
| Product name | estriol bulk powder |
| CAS | 50-27-1 |
| structural formula | C18H24O3 |
| molecular weight | 288.38 |
| EINECS | 200-022-2 |
| melting point | 280-282 °C(lit.) |
| boiling point | 370.61°C (rough estimate) |
| Acidity coefficient (pKa) | pKa 10.38±0.02(H2O t=23±2 Iunspeci(ed) (Uncertain) |
| density | 1.27 |
| Storage condition | 2-8°C,keep dry |
What is the difference between estriol and estradiol ?
In general, the differences between estradiol and estriol bulk powder are mainly structure, synthesis process, metabolism, site of action and efficacy.
1. Structure: Their main difference in structure lies in the length of side chain. The side chain length of estradiol is 18 carbon atoms, while that of estriol is 20 carbon atoms.
2. Synthesis process: Their synthesis process is different. Estradiol is mainly synthesized by ovarian granulosa cells, while estriol is synthesized by fetal placental unit.
4. Metabolism: Their metabolic pathways are different. Estradiol can be inactivated by various enzymes in the liver, and can also be absorbed by the glomerulus. The metabolites of estriol in vivo are 2- hydroxyestrone, 3- hydroxyestrone and 16α- hydroxyestrone.
5. Action site: Estradiol mainly acts on tissues and organs such as endometrium, cervix, fallopian tube, vagina, bone, muscle and fat. Estriol mainly acts on uterus, breast and sexual organs.
6. Efficacy: Estradiol can promote the development and maturity of female reproductive organs and maintain female reproductive function. estriol bulk powder, on the other hand, can promote the growth and development of the fetus and protect the breast from other hormones.
What is the use and efficacy of estriol ?
Estrogen including estriol plays a key role in a woman's life. Since puberty, estrogen has been involved in promoting the development of female sexual characteristics, such as the growth of breasts and the shaping of pelvis. During the reproductive period, estriol bulk powder helps to maintain normal menstrual cycle and fertility function. After menopause, the decrease of estrogen level may bring a series of health problems, such as osteoporosis and increased risk of cardiovascular disease. Appropriate supplementation of estriol or other estrogens is helpful to alleviate these discomforts.
Animal experiments show that it has stronger keratinization effect on vaginal epithelium than estradiol,
and can promote vaginal epithelial hyperplasia, superficial cell keratinization, mucosal angiogenesis and healing of vaginal epithelial injury, but it has weaker effect on uterine weight gain in mice.
At the same time, estriol bulk powder can enhance the function of cervical cells, make cervical muscle fibers proliferate, and increase the elasticity and softness of the cervix. In addition, this product has feedback inhibitory effect on hypothalamus and pituitary gland, but it does not inhibit ovulation, and only has obvious influence on yellow body, so it can be used as an auxiliary product for induced labor and induced abortion in the middle term and various menstrual diseases.
It also has obvious effect on hematopoietic system, can reduce the permeability and brittleness of blood vessels, and can be used for the treatment of various bleeding. It also has the effect of rapidly increasing peripheral white blood cells, and is effective for leukopenia caused by radiotherapy and chemotherapy.
Product Specification
| Items | Specifications | Results | ||
| Appearance | white crystalline powder | Complies | ||
| Assay | 98%-101% | 99.28% | ||
| Loss on Drying | ≤5.0% | 0.07% | ||
| Residue on Ignition | ≤0.1% | 0.04% | ||
| Heavy metals | ≤10ppm | 4.5ppm | ||
| As | ≤1ppm | ≤1ppm | ||
| Pb | ≤1ppm | ≤1ppm | ||
| Cd | ≤1ppm | ≤1ppm | ||
| Hg | ≤0.1ppm | ≤0.1ppm | ||
| Total Plate count | ≤1000CFU/g | <10CFU/g | ||
| Yeast &Mould | ≤100CFU/g | <10CFU/g | ||
| Escherichia Coli | Negative | Negative | ||
| P.aeruginosa | Negative | Negative | ||
| S.aureus | Negative | Negative | ||
| Salmonella | Negative | Negative | ||
| Conclusion: The test results are conformed to the in-house specification | ||||
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Attention: It should be noted that this product is not intended for the diagnosis, treatment, cure, or prevention of any disease. Please consult your doctor and learn about available research before use. Please do not use without authorization. This compound can only be used for research purposes. The US Food and Drug Administration has not evaluated these claims.
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