what is beta 17 estradiol?
Beta 17 estradiol appears as a white to off white crystalline powder at room temperature, with a fine texture, no odor, and no visible impurities to the naked eye. Its CAS number is 50-28-2, molecular formula is C ₁₈ H ₂₄ O ₂, and molecular weight is 272.38 g/mol. As the most important natural estrogen in the human body, Beta 17 estradiol powder can bind to estrogen receptors (ER α/ER β), regulate gene transcription, promote female reproductive organ development and maintain secondary sexual characteristics, while inhibiting bone resorption, providing cardiovascular protection and regulating nervous system function. Widely used in the fields of pharmaceutical preparations, assisted reproduction, veterinary drugs, and scientific research reagents.
 | Product name | beta 17 estradiol |
| CAS | 50-28-2 | |
| Molecular formula | C18H24O2 | |
| Molecular weight | 272.39 | |
| EINECS | 200-023-8 | |
| Appearance | white powder | |
| Melting point | 178-179 °C(lit.) | |
| Density | 1.0708g/cm3(Predicted) |
What is the uses of beta 17 estradiol?
| Beta 17 Estradiol can be used as an estrogen medication for functional uterine bleeding, primary amenorrhea, menopausal syndrome, and prostate cancer. Can promote and regulate the normal development of female genitalia and secondary sexual characteristics. It can promote the development and proliferation of mammary ducts, but at higher doses, it can inhibit the release of prolactin from the anterior pituitary gland and reduce milk secretion. It can also be used for milk return. Beta 17 Estradiol Can be used for biochemical research It is also an intermediate of Estradiol Valerate and Estradiol Benzoate. |
Product Specification
| Items | Specifications | Result |
| Appearance | White or creamy white crystalline powder | Conform |
| Identification | Infrared Absorpion | Positive |
| Melting point | 173 ~ 179℃ | 175.1℃ |
| Specific rotation | +76~ +83° | +79.08° |
| Water | ≤3.5% | 0.79% |
| Loss on drying | ≤0.5% | 0.16% |
| Related substances | any individual impurity ≤0 . 5% total impurities ≤ 1 . 0 % | Pass |
| Residual solvents | ethanol < 0.5% | Pass |
| Burning residue | ≤0.2% | 0.18 % |
| Sulphated ash | ≤0.1% | 0.1% |
| Particle size | 60 -40 mesh | Pass |
| Assay | 97.0 ~ 103.0% | 99.3% |
Conclusion：Conform with specification and qualified.
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how about the Mechanism of Action of beta 17 estradiol?
| Beta 17 estradiol is a lipophilic molecule and, therefore, passes through the cell membrane by passive diffusion, and in the cytoplasm, it binds to intracellular estrogen receptors The biologically active ligand–receptor complex induces a complicated sequence of events that begins with conformational changes in the receptor, followed by receptor dimerization, and leads to direct translocation of the activated ligand–receptor complex to the nucleus. This process is promoted by several chaperon molecules including heat hock protein 90 (HSP90) . The dimerized receptor complex interacts with several nuclear receptor coactivators, such as the 160-KD steroid receptor coactivator protein (P160) or the cyclic adenosine 3′, 5′-monophosphate (cAMP)-responsive element-binding protein (CREB) The entire complex then binds to a specific DNA sequence, the estrogen-responsive element (ERE), to stimulate transcription, which ultimately leads to the synthesis of new proteins Cytonuclear ERs are key receptors in activating the classical pathway. |
How to produce beta 17 estradiol?
 | Biosynthesis: Cholesterol is converted to Pregnenolone, which undergoes two steps of conversion and is finally converted to beta 17 estradiol by aromatase catalysis Reduce estrone to beta-estradiol: |
Company Profile
A variety of shipping methods for you to choose
| Transportation Time | Shipping method | Cargo weight requirements | Advantage |
| 3-7 days | DHL, Germany DHL, Germany DPD, UPS, USPS,FedEx, TNT,EMS | Suitable for under 50kg. International door to door express | We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
| 7-15 days | By Air | Suitable for more than 50kg. fast and cheaper for large order | |
| 15-60 days | By Sea | Suitable for more than 500kg. Cheapest shipping way |
FAQ:
Q1:What is estradiol metabolized into in the body?
A1: Estradiol is converted into relatively low activity estrone and estriol in the body.
Q2:Which is more active, estradiol or estriol?
A2:Estradiol is the most active and physiologically important component of estrogen.
Q3:What is the minimum order quantity?
A3:The minimum order quantity is 10g.
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