Steroids Raw Powder Estriol CAS 50-27-1

Steroids Raw Powder Estriol is a natural hormone, a metabolite of estradiol in vivo, which mainly exists in urine. Almost all Estriol(90%) binds to albumin in plasma. Unlike other estrogens, Estriol does not bind to sex hormone-binding globulin. Its metabolism is mainly the process of combination and dissociation in enterohepatic circulation. As the end product of metabolism, it is excreted mainly in the form of binding through urine, and only a small amount (2%) of mainly unbound Estriol is excreted through feces.

High-performance liquid chromatography (HPLC) can be used to detect the content change of Estriol efficiently and accurately. For common estrogens or similar substances of estrogen above, it can be detected with reference materials. For rare estrogens, we can provide customized detection if standard samples are provided.

What is Estriol?

Estriol, chemical formula: C18H24O3, white crystalline powder, molecular weight: 288.381, density: 1.255g/cm3, melting point: 280-282 C (lit.)

Steroids Raw Powder Estriol is a natural hormone, a metabolite of estradiol in vivo, which mainly exists in urine. Estrogen has low activity, and its oral activity is about 6 times that of estrone, but it is weaker than estradiol and has no carcinogenic effect. The level of estradiol in vivo does not change after taking the medicine. It has a selective effect on the vagina and cervical canal but has no effect on the uterine entity and endometrium. Animal experiments show that it has a stronger effect on vaginal epithelial keratosis than estradiol, and can promote vaginal epithelial hyperplasia, superficial cell keratosis, mucosal angiogenesis, and healing of vaginal epithelial injury, but it has a weaker effect on mouse uterus weight gain. At the same time, it can enhance the function of cervical cells, proliferate cervical muscle fibers, and increase the elasticity and softness of the cervix. In addition, it has a feedback inhibitory effect on the hypothalamus and pituitary gland, but it does not inhibit ovulation, but only has an obvious influence on the yellow body. Therefore, it can be used as an auxiliary drug for mid-term induced labor and induced abortion, and the treatment of various menstrual diseases. It also has an obvious effect on the hematopoietic system, can reduce the permeability and fragility of blood vessels, and can be used for the treatment of various bleeding. It also has the function of rapidly increasing peripheral white blood cells, which usually takes effect 1 ~ 3 days after taking the medicine, but the action time is short, and it is effective for leukopenia caused by radiotherapy and chemotherapy.

What is the purpose and function of Estriol?

1. Steroids Raw Powder Estriol is used for cervicitis, especially for menopausal syndrome and senile vaginitis.

2. It can be used as an auxiliary drug for mid-term induced labor and induced abortion.

3. Used for prostate hypertrophy, prostate cancer, etc.

4. It has the effect of rapidly increasing peripheral white blood cells, which usually takes effect from 1 to 3 days after medication, but the effect lasts for a short time. It is effective for leukopenia caused by chemotherapy or radiotherapy.

5. It can reduce the permeability and fragility of blood vessels, can be used for the treatment of various kinds of bleeding, and can quickly stop bleeding after menorrhagia, tonsillectomy or hysterectomy.

6. It can treat vaginal symptoms, such as dryness, sexual pain, and itching.

7. It can prevent recurrent infection of the vagina and lower urethra.

8. It can be used for urination symptoms (such as frequent urination and pain) and mild urinary incontinence.

9. It is used for premenopausal women before and after the vaginal operation.

10. It is the auxiliary diagnosis of suspected atrophic cervical film.

How to evaluate the sustained-release effect of estriol in vitro?

Estrogen mainly comes from ovarian follicular endometrial cells and follicular granulosa cells, mainly estradiol, followed by estrone and estriol, etc. The corpus luteum, placenta, adrenal cortex, and testis of male animals can also secrete a small amount of estrogen. Estriol can selectively act on the cervical and vaginal epithelium and is suitable for the treatment of cervicitis, menopausal syndrome, and atrophic vaginitis. Atrophic vaginitis is a common gynecological disease. Menopausal women often suffer from abnormal leucorrhea and pruritus vulvae. In severe cases, vulvar erosion, vaginal adhesion, and thrombosis may occur, which seriously affects the physical and mental health of patients. At present, there are mainly metronidazole suppository, Baofukang suppository, Tibolone tablets, hyaluronic acid, estriol cream, and so on for the treatment of atrophic vaginitis. Triestrol cream needs to be used daily, and patients' compliance is poor. It is of great significance to study estriol sustained-release preparation.

Since estriol was discovered in 1930, experts have been working on the research of separation and purification from pregnant women's urine.

What are the adverse reactions to Estriol?

And benign estrogen-dependent tumors, such as endometrial cancer and breast cancer. The incidence of venous thromboembolism (i.e. deep venous thrombosis and pulmonary embolism of lower limbs or pelvic cavity) among HRT users is higher than that among non-users. Due to the lack of relevant information, it is not clear whether the origin is different from other similar drugs in this respect. Myocardial infarction and stroke, gallbladder diseases, skin, and subcutaneous tissue abnormalities: chloasma, erythema multiforme, erythema nodosum and vascular purpura, suspected dementia, breast cancer. According to a large number of epidemiological studies and data provided by a randomized placebo-controlled trial women's Health Initiative (WHI), among current or recent users of HRT, the overall risk of breast cancer increases with the extension of treatment time.

Expert evaluation of estriol

Estriol has low estrogenic activity, and has obvious effects on blood vessels, hypothalamus-pituitary-gonad feedback system, and hematopoietic system, and can selectively act on the distal part of the female reproductive tract and male mammary gland, testis, and prostate. It is commonly used for leukopenia, various menstrual diseases, and climacteric syndrome. It is characterized by the selective effect on the vagina and cervical canal, but no effect on the uterine body and endometrium. In addition, it can increase peripheral white blood cells and reduce the permeability and fragility of blood vessels.

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Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure or prevent any disease.

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