Medroxyprogesterone Acetate Powder CAS 71-58-9

Medroxyprogesterone Acetate powder is a synthetic hormone, specifically a progestin, that mimics the effects of the natural hormone progesterone in the body. It's used to treat various conditions, including menstrual problems, endometriosis, and certain types of cancer, as well as for contraception.

The anti-tumor effect of Medroxyprogesterone Acetate may be related to its anti-estrogenic effect. When used in large quantities, Medroxyprogesterone Acetate can counteract the effect of estrogen on promoting tumor cell growth and has a direct cytotoxic effect on sensitive cells, but no such effect on drug-resistant cells. It can also reduce the level of intracellular estrogen by enhancing the activity of E2-deoxyase, induce liver 5α -reductase to prevent androgens from being converted into estrogen, etc., thereby generating anti-tumor effects. In addition, Medroxyprogesterone Acetate can also inhibit the production of LH adrenocorticotropic hormone (ACTH) and other growth factors through a negative feedback effect on the adenopituitary gland.

Medroxyprogesterone Acetate powder can increase the level of calcium in the plasma, and there have been reports of individual hypercalcemia in the treatment of breast cancer. This product should be kept out of the reach of children. Warning: Medroxyprogesterone Acetate should be administered under the guidance of a doctor with experience in cancer chemotherapy. Because Medroxyprogesterone Acetate has the ability to enhance blood coagulation, if symptoms such as thromboembolic diseases, migraine, sudden partial or complete blindness, diplopia, optic disc edema, and retinal vascular damage occur, its use should be immediately stopped. If vaginal bleeding occurs, a careful examination should be conducted to confirm the diagnosis. If histological examination is required, the laboratory personnel should be informed that the patient is receiving treatment with progesterone drugs.