Fludarabine Powder CAS 21679-14-1

Fludarabine Powder is an antitumor drug. Fludarabine is an anti-metabolic purine nucleoside fluoride analogue, which is highly selective to lymphocytes. It can inhibit DNA repair in quiescent cells and DNA synthesis in dividing cells, and promote apoptosis of these cells. Fludarabine has shown good therapeutic effect, and has been widely used in the treatment of various blood system diseases. Especially chronic B lymphocytic leukemia.

The drug is a fluorinated nucleotide analogue of adenosine arabine, which is relatively resistant to the deamination of adenosine deaminase. Fludarabine phosphate is rapidly dephosphorylated to 2F-ara-A, which can be taken up by cells and then phosphorylated by intracellular deoxycytidine kinase to the active triphosphate 2F-ara-ATP. The metabolite can inhibit DNA synthesis by inhibiting nucleotide reductase, DNA polymerase, DNA primer enzyme, and DNA ligase. In addition, RNA polymerase II can be partially inhibited to reduce protein synthesis.