Earlier, we said that NAD+ is the root of this metabolism, which means that without NAD+, mitochondria can't be metabolized, which makes our cells lose energy and eventually die.
The place where NMN is increased to prolong life span is that many of these physical functions will decline with age. By ensuring that the NAD+ level can be maintained or supported during this aging process, the hypothetical goal is to mitigate the normal aging process as much as possible, so as to allow all body systems to achieve optimal functions for a long time without the optimal level of dysfunction and the risk of diseases increasing significantly.
γ -butyl betaine ethyl ester hydrochloride (50mg)
The Gamma Butyrobetaine Ethyl Ester HCL (CAS.NO: 51963-62-3) Abbreviated as GBB, Pro GBB. it can increase L-carnitine available in the body, thus increasing the ability of mitochondria to obtain energy by using fatty acids. GBB is a naturally occurring molecule in the body, which helps to enhance the nonessential amino acid L-carnitine. L-carnitine plays a key role in energy production by transporting fatty acids to the mitochondria of cells ("the power of energy production") for energy production. Studies have shown that when GBB exists, it can increase the supply of L-carnitine in the body, thus providing enhanced benefits.
Therefore, in short, GBB increases the L-carnitine available in the body, thus increasing the ability of mitochondria to obtain energy from fatty acids. With the goal of reducing body fat and even improving performance, L-carnitine has shown special benefits in this field. A study on mammals focused on the response of L-carnitine supplementation to growth performance and circumference measurement. The results showed that the weight of muscle tissue increased, while the percentage of abdominal fat decreased.
Extracts from Radix Astragali and Radix Notoginseng(50mg)
The combination of Radix Astragali and Radix Notoginseng is superior to separate use. According to clinical research and observation and relevant statistical data, the absorption of creatine, leucine, citrulline and other peptides increased by 67%, the absorption of curcumin increased by 92%, the polyunsaturated fatty acids (from flax and fish oil) increased by 58% and 100% respectively, and the ATP production in the liver increased by 18%. In particular, it is proved that this product can increase muscle protein synthesis by enhancing leucine absorption and improve glucose metabolism and affect mitochondrial function by increasing mTOR. It can improve the absorption of nutrients, peptides and amino acids and has been widely used in the supplement manufacturing industry.
In addition, it is very important to ensure the high permeability environment around the mitochondrial membrane for maintaining mitochondrial function. This permeability allows key electrochemical chemicals to pass through the gradient, thus carrying out the energy development process for cells.
Pyrroloquinoline quinone (50mg)
We know that the existence of more mitochondria and their health will have an impact on overall health, energy level, inflammation level and oxidative stress. These mitochondrial dysfunction can play a role in many chronic diseases and other metabolic disorders.
Pyrroloquinoline quinone, also known as PQQ, is a powerful redox cofactor, which can be used as an oxidant and antioxidant to protect human cells from oxidative damage by restoring redox balance. It has also been proved to support energy metabolism and healthy aging.
Animal studies also show that the lack of PQQ will reduce the number and size of mitochondria by more than 20%-20%. PQQ supplements can increase mitochondrial biosynthesis by activating the mechanisms of proliferator-activated receptor-γ-coactivator -1 α (PGC-1α) and 3',5'- cyclic adenosine monophosphate response element binding protein (CREB).
Studies on animals show that supplementation of PQQ stimulates this PGC-1α mediated mitochondrial biogenesis through sirtuin 1 activity, and may also activate 5'- adenosine monophosphate activated protein kinase (AMPK), which is another important regulator of mitochondrial biogenesis.
Although most of the research on PQQ is carried out on animals, human research also shows hope. A randomized controlled trial for men also participated in an endurance exercise program. The results showed that although there was not much difference in performance indicators between the two groups, the level of PGC-1α protein increased significantly.
This is probably related to the increase in the number of mitochondria in the supplementary group. Although exercise can indeed propagate mitochondria through biogenesis, PQQ supplements may also play a role by constructing new mitochondria. When exercise becomes less frequent and we stop our ability to stimulate new mitochondria, supplementing PQQ can be an important tool to prolong life.
Spermidine trihydrochloride(1mg)
This may be common sense, but it is important to remember that effective cell function is crucial to our overall health, health and longevity. We often only discuss the big variables, such as training, macronutrients, sleep, etc., because they are essential (they are), and we often forget the importance of how our cell building blocks and our internal sports fields affect our overall happiness and health, as well as health goals. First of all, improving body function at the cellular level may be more effective in some aspects, because it involves solving some problems from the source or providing support where most problems usually start. Cells participate in all processes and functions of our body. Judging from metabolism, respiration, muscle growth and organ function, our body is basically controlled by cells and their behaviors. Now, just as our daily obligations require us to be focused, healthy and ready to undertake tasks, our bodies also rely on these cells to function physically under the harsh conditions that our bodies experience. Our bodies use several processes to ensure that our cells can exert their required abilities. Apoptosis or programmed cell death; Necrosis or premature death; And autophagy, or processing dead cells (recycling). Spermidine is a polyamine, which is thought to enhance this autophagy process. This recycling of dead cells enables them to be used in other parts of the body to maintain health. This defense mechanism has been proved to support the regression of metabolic disorders, neurodegenerative diseases and signs of aging. This process will slow down with age, so it is very important to use tools that help maintain this recycling process to prolong life. Spermidine can actually be found in the food we eat. Mushrooms, broccoli, viscera, apples, etc. are only a few of them, but it has been proved that supplements are also essential to keep our spermidine level rising with the increase of age and if these foods are not ingested in sufficient quantities on a daily basis. Although the clinical data of spermidine are limited to in vitro experiments or mouse experiments, these experiments do provide some evidence for improving the health variables related to human aging, because it has an impact on important cell structures such as mitochondria at the cellular level. Therefore, the use of tools that help to maintain this recycling process is essential to prolong life.
Although we can't stop ourselves or important parts of our bodies from aging, we do have the ability to influence our life span in a positive way.
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