Osteoporosis is a kind of systemic bone disease characterized by low bone mass and damage of bone microstructure, which leads to increased bone fragility and prone to fracture, and is more common in postmenopausal women and elderly men.
1.What are the hazards of osteoporosis?
Osteoporosis causes bones to become fragile and significantly increases the risk of fractures due to minor events.
Worldwide, one in every three women aged 50 and above and one in every five men suffer from osteoporosis. Osteoporosis may cause pain and may lead to disability and loss of independence.
Fractures caused by osteoporosis usually occur in the hip, spine, and wrist, which together account for about half of the total number of fractures in the elderly, while the rest occur in other parts of the bone. In young people, trauma is the main cause of fractures (such as falling from a tree, car accidents, etc.), while in older people, especially women over 50 years old and men over 70 years old, fractures usually occur in mild or no obvious trauma, such as when turning over in bed.
People actually break bones without their knowledge, without knowing the cause or realizing that it can be prevented.
2.What is the principle of osteoporosis?
Bone density increases during childhood and adolescence due to the collagen layer in the bones containing calcium, but osteoporosis reduces collagen and minerals, making bones fragile.
Fractures are more likely to occur in bones rich in trabecular bones, such as the neck of the femur, which has obvious mechanical weaknesses and lower density, and is updated approximately every 10 to 12 years.
Our bodies constantly renew proteins, including bones, although the rate of bone renewal is slow and varies depending on the individual and within the bones. The bone turnover cycle eliminates damaged bone tissue and replaces it with new bone, and the role of different bone cells promotes this process.
This remodeling process provides the possibility of treating osteoporosis.
3.What are the manifestations of osteoporosis affected by different factors?
Osteoporosis fractures manifest differently at different time periods. Hip fractures typically occur after a fall, spinal fractures are typically detected on X-rays, and wrist fractures are often caused by slipping on icy roads. Age can affect bone strength and the consequences of fractures. Over time, reflexes gradually weaken, changing the likelihood of injury during falls.
Osteoporosis can also be caused by factors such as female menopause, where a lack of estrogen can hinder bone turnover. Another factor is that with age, Vitamin D deficiency leads to insufficient calcium absorption in the intestine, thereby increasing the risk of fractures.
The decrease in estrogen levels may lead to an increase in bone resorption cell activity and a decrease in bone forming cell activity, thereby exacerbating bone loss in osteoporosis. The estrogen receptors on bone cells indicate a link between estrogen and bone health, and clinical trials have shown that estrogen may slow down bone loss.
4.What are the effects of various supplements on osteoporosis?
Calcium is sufficient even at low intake levels, unless supplementation may be necessary in extremely low calcium diets such as strict vegetarianism.
Vitamin D mainly comes from sunlight, and it is recommended to supplement for groups with limited exposure to sunlight, such as the elderly or immigrants.
Although popular beliefs support the benefits of calcium and vitamin D supplementation for bone health, research has not consistently confirmed their efficacy and pointed out possible risks, especially with calcium supplements.
A diverse plant-based diet can provide sufficient calcium without the need for supplementation, but it may be necessary for individuals undergoing specific osteoporosis medication treatments. The professor mentioned that drinking Italian mineral water alone can also supplement calcium.
Conventional calcium supplementation is not widely recommended, although it is generally considered beneficial by the public, as evidence from experiments does not support significant benefits and may even show potential harm.
The results of vitamin D supplementation trials are also inconsistent, with some trials showing limited benefits and others showing potential harm, contradicting government guidelines promoting universal supplementation practices.
Even within the recommended dosage, excessive intake of vitamins and calcium may pose risks, especially considering our evolutionary absorption mechanisms and potential over supplementation.
However, prenatal vitamin D supplementation may be beneficial for the bone health of offspring, while the benefits of pediatric supplementation are less clear, emphasizing that balanced nutrition is more important than supplementation for optimizing bone health.
5.How much does diet and exercise affect osteoporosis?
Diet plays an important role in osteoporosis, and the quality of the diet, rather than specific nutrients such as calcium or zinc, has a significant impact on the risk of fractures. Consuming a large amount of vegetables, reducing processed and junk food, and avoiding excessive carbonated beverages can help form a high-quality diet, which is associated with a 30-40% reduction in the risk of fractures. This emphasizes the importance of dietary quality in promoting bone health, rather than individual nutrients.
In the past, it was widely believed that increasing calcium intake could directly affect bone health, but recent research has revealed the fallacy of this notion, emphasizing that overall dietary quality is more important than specific nutrients such as calcium. Although calcium is crucial for bone health, simply increasing calcium intake does not necessarily make bones stronger.
On the contrary, focusing on consuming rich plant-based foods provides the balanced minerals needed for bone health, such as zinc, magnesium, and phosphorus. This comprehensive nutritional approach is more effective than relying solely on single supplements such as vitamin D or increasing calcium intake.
A highly active lifestyle, similar to our ancestors, may reduce the incidence of osteoporosis in old age as exercise affects bone strength.
Historical data shows that a decrease in physical activity levels is positively correlated with an increase in fracture rates, indicating that modern sedentary lifestyles increase the risk of osteoporosis. This contradicts the traditional notion that elderly people should live a relaxed life, emphasizing the importance of maintaining physical activity and avoiding excessive protection for the elderly to maintain bone health.
Regular weight bearing exercises, such as brisk walking or jumping, can significantly increase bone density and reduce the risk of falls and fractures in the elderly. Although activities such as swimming also have benefits, they may not have the same strengthening effect on bones as weight-bearing exercises. Weight lifting training, such as weightlifting, can also promote an increase in bone density, although its impact on fracture risk is still unclear. The key is to participate in activities that exert pressure on the bones, stimulate bone forming cells, and promote bone health.
6.What is the role of Abaloparatide in osteoporosis?
Abaloparatide powder is an artificially synthesized parathyroid hormone related protein (PTHrP) analogue that promotes bone formation by selectively activating the signaling pathway of parathyroid hormone type 1 receptor (PTH1R). Its mechanism of action is unique, with a higher affinity for the RG conformation of PTH1R, resulting in a shorter duration of intracellular signaling. While promoting bone formation, its stimulating effect on bone resorption is relatively weak, effectively increasing bone density.
In clinical applications, Abaloparatide is mainly used to treat osteoporosis in postmenopausal women at high risk of fractures. Research shows that after 18 months of treatment, lumbar spine bone density can increase by 11.2%, total hip bone density can increase by 4.2%, and femoral neck bone density can increase by 3.6%. More importantly, the drug can significantly reduce the risk of fractures, reducing the risk of new vertebral fractures by 86%, non vertebral fractures by 43%, and clinical fractures by 43%. Compared with Teriparatide acetate , Abaloparatide showed better performance in improving hip and femoral neck bone density, with a lower incidence of hypercalcemia (3.4% vs 6.4%) and better safety.
7.Why choose our Abaloparatide powder?
The Abaloparatide raw material provided by Xi'an Faithful BioTech Co., Ltd company has multiple significant advantages in the treatment of osteoporosis. The product adopts advanced production technology, the purity is ≥98.5%, the impurity content is strictly controlled within 1.0%, the single impurity is less than 0.5%, the biological activity is ≥80.0%, the endotoxin is ≤50EU/mg, and all the quality indexes meet the international pharmacopoeia standards. Clinical data show that after 18 months of treatment, the bone mineral density of lumbar spine increased by 11.2%, hip bone mineral density increased by 4.2%, the risk of new vertebral fracture decreased by 86%, and the risk of non-vertebral fracture decreased by 43%. Compared with teriparatide, it is better in improving the bone mineral density of hip and femoral neck, and the incidence of hypercalcemia is only 3.4%, which is significantly lower than that of teriparatide, and it is safer. In addition, our products are more competitive in price and have obvious cost-benefit advantages, making them an ideal treatment choice for patients with high risk of fracture and osteoporosis.
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