What is Fmoc-Ala?
Headquartered in Xi'an, the historic origin of the ancient Silk Road, Xi'an Faithful BioTech Co., Ltd. takes full advantage of the city's robust logistics and chemical industrial resources to develop into a comprehensive fine chemical supplier serving clients worldwide. Fmoc-Ala, CAS 35661-39-3, with the molecular formula C₁₈H₁₇NO₄, is the most widely used amino-protected amino acid building block in peptide chemistry. It appears as a uniform white crystalline powder, exhibiting stable physicochemical properties and a melting point between 147 and 154 degrees Celsius. This molecule uses L-Alanine as its basic backbone, with an Fmoc fluorene methoxycarbonyl protecting group attached to the amino terminus, while the carboxyl terminus retains its free active structure. These two functional groups enable orthogonal controllable reactions. As a fundamental unit for various artificial peptides, the alanine side chain contains only a short methyl group. Its insertion into the peptide chain allows for flexible control of molecular spatial flexibility, often used to construct spacer sequences and mimic natural protein fragments. It widely serves laboratory research and development in areas such as molecular interaction investigation, biochemical probe preparation, and cyclic peptide assembly.
Fmoc-Ala Manufacturing Process
Using L-Alanine as a raw material, an organic phase mixed solvent was added to an alkaline aqueous solution system. Fluorene methyloxycarbonyl acylation reagent was added in batches under controlled temperature, and the reaction was carried out under light-protected stirring until fully induced. The reaction solution was acidified to precipitate a solid, which was then extracted and washed with water to remove water-soluble impurities. The organic phase was dried and concentrated, purified by solvent recrystallization, filtered, and dried at low temperature to obtain a high-purity acylated protected amino acid intermediate.
COA
| Test Item | Specification | Test Result |
| Appearance | White to off-white crystalline powder |
White crystalline powder |
| Purity(HPLC) | ≥98.0% | 99.21% |
| Specific Rotation [a]2zo/D (c=1,DMF) |
-16.0°~-20.0° | -18.3° |
| Melting Point | 147℃~154℃ | 149℃~152℃ |
| Water Content(Karl Fischer) |
≤0.5% | 0.22% |
| Residue on Ignition | ≤0.1% | 0.05% |
| Single Impurity(HPLC) | ≤0.5% | 0.18% |
| Tota Impurities(HPLC) | ≤1.0% | 0.79% |
| Solubility(DMF/DCM) | Clear and transparent solution |
Complies |
| Conclusion | Conform with enterprise specification | |
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Density 1.3±0.1 g/cm³
Boiling point 544.1±33.0 °C at 760 mmHg
Melting point 150-154ºC
Molecular formula C18H17NO4
Molecular weight 311.332
Flash point 282.9±25.4 °C
Exact mass 311.115753
PSA 79.12000
LogP 3.54
Mechanism of action of FMOC-Ala-OH
1. Amino group blocking and protection mechanism: The fluorene methoxycarbonyl group binds to the amino group of the amino acid, blocking spontaneous side reactions of the amino group and preventing self-polymerization of the molecule, leaving only the carboxyl group to participate in the condensation reaction.
2. Controllable removal mechanism: The protecting group can be completely removed under a weakly basic environment without destroying the already formed peptide bond structure, enabling segmented and stepwise splicing of the molecular chain.
3. Peptide chain structure regulation mechanism: The short methyl side chain itself has no additional active groups, and no side chain side reactions are generated after it is added to the chain segment. It can also regulate the spatial flexibility of the molecule.
4. Coupling reaction activation and adaptation mechanism: The free carboxyl group can be activated with condensation reagents, stably and efficiently condensing with the support and other amino fragments, adapting to the entire solid-phase synthesis process.
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Package
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| Transportation Time | Shipping method | Cargo weight requirements | Advantage |
| 3-7 days | DHL,Germany DHL,Germany DPD, UPS,USPS,FedEx,TNT,EMS |
Suitable for under 50kg. International door to door express |
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| 7-15 days | By Air | Suitable for more than 50kg. fast and cheaper for large order |
|
| 15-60 days | By Sea | Suitable for more than 500kg. Cheapest shipping way |
FAQ
01. What synthetic process is this raw material primarily used for?
Fmoc-Ala is mainly used in solid-phase peptide synthesis as a basic building block.
02. What are the advantages of the side chain structure of alanine?
The side chain contains only a methyl group and no active functional groups, preventing side chain side reactions during synthesis.
03. What conditions must be met for daily storage?
Store in a sealed, light-proof, low-temperature, moisture-proof environment, away from strong alkaline environments.
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Disclaimer: All conventional products (non-customized products) pictures are taken in kind, but due to the influence of light (different time, different background light), shooting method, different display equipment parameters and other factors, there may be some differences between the picture and the real color, product color, please take the real effect prevail, product color difference is not a product quality problem.
Note: Always consult a qualified health practitioner before taking any new medication. This product is not intended to diagnose, treat, cure or prevent any disease.At the time of purchase, the international buyer agrees to assume the risk of all items arriving. We cannot replace lost or impounded items. Before sending items, you need to confirm that you agree to these terms.This is only a recommended dose based on our own experience and anecdotal evidence. We recommend that you do your own research before using this product.
Statement: This product is only used for scientific research, and the consequences of other uses are not responsible.
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