Glycyl-L-Glutamine CAS 13115-71-4

Glycyl-L-glutaMine Monohydrate is an enzyme cleavage product of β - endorphin and an endogenous antagonist of β - endorphins (1-31). Research has found that Glycyl glutamine is an active neuropeptide with higher stability than glutamine (Gln). The pharmaceutical industry often uses glycine and L-glutamine as the main raw materials. Glycine is first protected with phthalic anhydride to form acyl chloride, which is then amidated with L-glutamine. Finally, Not purified Glycyl-L-Glutamine powder is obtained by deprotection with hydrazine hydrate in methanol.

What are the pharmacological effects of Glycyl-L-Glutamine?

Glycyl-L-Glutamine, as the most abundant conditioned amino acid in the blood and free amino acid pool in the body, has a wide range of physiological functions: 1) maintaining the body's immune function. It is an important energy source for many immune cells and small intestinal mucosal epithelial cells. Glutamine has a protective and reparative effect on gastric and intestinal mucosal damage, as it promotes the biochemical synthesis of hexosamine and glucosamine, which are components of the gastric and intestinal mucosal epithelium. 2) Regulate the synthesis and breakdown of proteins. Glycyl-L-glutamine monohydrate is an important regulator of protein synthesis, which can regulate protein synthesis and reduce muscle protein breakdown during exercise, thereby maintaining physiological functions of the body. 3) Gly-L-Gln-OH is an important carrier of nitrogen and carbon in the body. 4) Maintain acid-base balance in the body. It can serve as a carrier for ammonia generated by the kidneys, directly participating in ammonia metabolism and playing an important role in maintaining acid-base balance. 5) Regulate sugar metabolism. It can generate glucose through gluconeogenesis and maintain blood glucose concentration balance.

What is the application of Glycyl-L-Glutamine in sports health care?

Glutamine is the most abundant free amino acid in human body. It is not only a regulator of DNA synthesis, an important energy substance for RNA synthesis in mucosal cells, but also an important fuel for many immune cells in the immune system. Exercise affects the level of glutamine in the free amino acid pool, and the change of Gln level reacts on immune cells, resulting in a series of chain reactions. In sports, the level of L- glutamine in plasma has attracted much attention as an index to evaluate overtraining. Determination of L- glutamine in blood can be used as a detection and evaluation index of overtraining. The level of Gly-Gln-OH in bodybuilders and competitive athletes can be reduced by 50% during high-intensity strength training. At this time, timely supplementation of glycyl-L-glutamine can effectively prevent the decomposition of muscle protein.

What are the medicinal uses of Glycyl-L-Glutamine?

Glycyl -L- glutamine can be used as a thermal stability substitute for glutamine in mammalian cell culture medium. After use, Glycyl-L-Glutamine can separate the free glutamine state. At the same time, high-quality N2-Glycyl-L-glutamine powder, as an amino acid nutritional drug, can be used to improve the cellular immune function of patients. Effectively reduce the risk of infection in critically ill patients, especially for the treatment and recovery of critically ill patients such as serious infection and malignant tumor.

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