FMoc-DL-Glycine Introduction
Xi'an Faithful BioTech Co., Ltd. is an export-oriented biotechnology and chemical trading company headquartered in Xi'an, Shaanxi Province, China. Founded in 2018, the company focuses on providing pharmaceutical intermediates, plant extracts, food additives, and feed ingredients to the global B2B market.
As a lean, professional supplier, we implement rigorous quality control to ensure batch stability and compliance. With an experienced international sales team, we offer highly competitive prices, reliable delivery times, and one-stop export services.
Our products are widely supplied to the pharmaceutical, health supplement, cosmetic, and feed industries in Europe, North America, Southeast Asia, and the Middle East.
FMoc-DL-Glycine has a white powder appearance, with the CAS number 29022-11-5; its molecular formula is C17H15NO4; its molecular weight is 297.31; and its EINECS number is 249-373-3. This product is widely used in solid-phase peptide synthesis experiments and belongs to the Fmoc-modified Glycine derivative. Fmoc-Gly-OH is often used in proteomics-related experiments, sugar-binding compound preparation, and the synthesis of various macrocyclic peptides and peptides with special structural modifications. Most of these products on the market are chemically synthesized and mass-produced by professional biochemical reagent companies, such as Iris Biotech and Jil Biochemical, etc., and they have standardized supply.
What is the use of FMoc-DL-Glycine?
FMoc-DL-Glycine is mostly used in experiments related to the synthesis of peptides and various functional molecules. It is a very common basic raw material in the solid-phase peptide synthesis process. By relying on its inherent Fmoc protecting group, it can precisely attach Glycine to the peptide chain in the prescribed sequence. It is frequently used in proteomics research, the development of new peptide drugs, and the preparation of peptide-based biological materials. Besides the core peptide chain synthesis, it also has many specific application scenarios: when synthesizing complex peptide segments containing Glycine and prone to aggregation, when combined with the Fmoc-Gly-(Dmb) Gly-OH derivative and added together, it can significantly improve the synthesis success rate, and can also be used to prepare special-structured peptides such as heterotrimeric collagen peptide with functional antigenic sites; at the material development level, it can act as a small molecule connection fragment to build dumbbell-shaped dendrimer-like peptide macromolecules. These products have practical potential in the field of biomedicine; at the same time, Fmoc-Gly-OH can also undergo coupling reactions with β-glycosylamines of carbohydrates, which can not only achieve oligosaccharide fractionation but also be used to prepare new glycoconjugates.
What is the development prospect of FMoc-DL-Glycine?
The market development space of Fmoc-Gly-OH is deeply tied to the overall growth of the downstream polypeptide bioactive molecule industry. The strong demand brought by popular active products such as GLP-1 receptor modulators is driving the implementation of large-scale production using the Fmoc solid-phase polypeptide synthesis process, stabilizing the stable market demand base for this L-tert-Leucine building block.
At the same time, the industry is also facing competitive pressure from new green production routes. Many research teams are developing peptide assembly schemes without the need for strong acid-base systems, such as photocatalysis. In the long run, this will gradually adjust the market demand structure for traditional Fmoc-modified L-tert-Leucine raw materials.
To maintain long-term market competitiveness, FMoc-DL-Glycine needs to follow two core development paths: On the one hand, it needs to continuously improve purification processes and strictly control various trace impurities, taking the path of high-quality fine raw materials, matching the strict quality control standards of downstream polypeptide products; on the other hand, it needs to optimize the entire set of synthesis supporting processes, combining microwave and continuous flow reaction equipment to improve the cost-effectiveness of the entire solid-phase synthesis system, and actively expanding cross-border application scenarios such as oligosaccharide coupling complexes and new bio-functional polymers, completing the product upgrade from ordinary basic chemical raw materials to high-value specialized synthesis building blocks.
MF of FMoc-DL-Glycine
| CAS | 29022-11-5 |
| Molecular formula | C17H15NO4 |
| Molecular weight | 297.31 |
| EINECS | 249-373-3 |
| Melting point | 174-175 °C |
| Density | 1.1671 |
Specification
| Item | Specification | Result |
| Appearance | White powder | complies |
| Solubility | 0.5mmole in 5ml DMFclearly soluble | clearly soluble |
| IR Spectrum | In accordance with structure | In accordance with structure |
| Water(K.F) | ≤1.0% | 0.20% |
| Any other impurity | <0.30% | 0.18% |
| Purity (HPLC) | >99.0% (Area %) | 99.40% |
| Assay (AT) | >98.5% (AT) | 99.30% |
| Conclusion | Conform with enterprise specification | |
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A variety of shipping methods for you to choose
| Transportation Time | Shipping method | Cargo weight requirements | Advantage |
| 3-7 days | DHL,Germany DHL,Germany DPD, UPS,USPS,FedEx,TNT,EMS |
Suitable for under 50kg. International door to door express |
We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
| 7-15 days | By Air | Suitable for more than 50kg. fast and cheaper for large order |
|
| 15-60 days | By Sea | Suitable for more than 500kg. Cheapest shipping way |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide Fmoc-Gly-OH etc. at a more favorable price. If you are interested, please leave a message.
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.
FAQ:
Q1:Can FMoc-DL-Glycine be applied to non-traditional peptide synthesis?
It has practical applications in various fields such as sugar chemistry research and development, preparation of biological polymers, construction of composite detection molecules, and continuous new synthesis processes for non-classical polypeptide synthesis. It is a universal L-tert-Leucine synthesis building block that can be adapted to multiple research areas.
Q2:What are the core advantages of FMoc-DL-Glycine compared to Boc-Gly-OH?
The Fmoc group can be selectively removed under mild alkaline conditions, without the need for the repeated use of the strong acid TFA in the Boc strategy. This avoids the risk of peptide chain hydrolysis and is more suitable for the synthesis of long peptides, cyclic peptides, and complex sequences with acid-sensitive side chain protecting groups.
Q3:What are the adverse reactions of FMoc-DL-Glycine?
Although this product is not classified as a hazardous substance, it may cause irritation to the eyes, respiratory tract and skin. It is recommended to wear protective gloves and goggles in a well-ventilated area when operating.
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