What is L-Lysine Diisocyanate?
Headquartered in Xi'an, the historic origin of the ancient Silk Road, Xi'an Faithful BioTech Co., Ltd. takes full advantage of the city's robust logistics and chemical industrial resources to develop into a comprehensive fine chemical supplier serving clients worldwide. L-Lysine Diisocyanate, abbreviated as LDI, CAS number 45172-15-4, with the molecular formula C₁₀H₁₄N₂O₄ and a molecular weight of 226.23, is an aliphatic bio-based diisocyanate monomer derived from a natural amino acid backbone. At room temperature, it is a pale yellow to light yellow viscous transparent liquid. It exhibits the high reactivity typical of isocyanate groups and is sensitive to moisture, requiring storage in a low-temperature, sealed, and light-protected environment to prevent premature cross-linking and deterioration. This substance is synthesized using renewable L-Lysine as a base material. Unlike traditional petroleum-based aromatic diisocyanates, its molecular structure does not contain aromatic rings that easily cause yellowing. Furthermore, after degradation, it generates natural lysine and low-carbon alcohol molecules, leaving no harmful residues. It is an environmentally friendly polymerization intermediate that is a key area of research in the field of green polymers.

L-Lysine Diisocyanate Manufacturing Process
At the synthesis process level, the industry mainstream adopts the three-phosgene temperature-controlled synthesis route to avoid the safety risks caused by the direct use of highly toxic phosgene. By controlling the reaction temperature and inert protective atmosphere, the purity of the product is improved. After purification, the purity can be stably reached above 95%, which is suitable for laboratory research and development and industrial batch polymerization needs.
COA
| Test Item | Specification | Test Result |
| Appearance | Pale yellow transparent viscous liquid | Pale yellow transpare |
| Molecular Weight | 226.23 | 226.23 |
| Purity (HPLC) | ≥95.0% | 97.35% |
| Water Content | ≤0.1% | 0.06% |
| Free Isocyanate Group Content | 36.0~38.0% | 37.12% |
| Residual Solvent(Toluene) | ≤0.05% | 0.02% |
| Color Value(APHA) | ≤150 | 110 |
| Hydrolysable Chloride | ≤0.03% | 0.01% |
| Heavy Metals(Pb) | ≤10 ppm | <1 ppm |
| Conclusion | Conform with enterprise specification | |
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Density 1.128 g/cm³
Boiling point 304.989ºC at 760 mmHg
Molecular formula C10H14N2O4
Molecular weight 226.22900
Flash point 125.688ºC
Exact mass 226.09500
PSA 85.16000
LogP 0.76000
Mechanism of action of L-Lysine Diisocyanate
The dual-terminal -NCO groups undergo addition with hydroxyl and amino groups to crosslink and form polyurethane/polyurea polymers.
The lysine carbon chain structure allows for mild degradation of the finished product, leaving no harmful residues.
The aliphatic structure contains no benzene rings, making the material UV resistant and less prone to yellowing and aging.
The active groups can be grafted onto fillers/polymers to enhance interfacial adhesion.

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FAQ
01. What advantages does an aliphatic structure offer?
It contains no aromatic rings, making the resulting materials resistant to UV exposure and less prone to yellowing and aging with long-term use.
02. How does it improve the performance of composite materials?
Active isocyanate groups can be grafted onto fillers and polymer surfaces, enhancing the adhesion between different materials.
03. What is the biggest difference between it and aromatic isocyanates?
L-Lysine Diisocyanate contains no aromatic rings, exhibits excellent resistance to yellowing, is biodegradable, and has better eco-compatibility.
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