Natamycin powder is an almost odorless white to creamy yellow crystalline raw material, and the crystalline form of Pimaricin is very stable. The solubility in water and most organic solvents is very low. However, since its first isolation from Streptomyces natale in 1955, it has been found that its activity is far superior to that of sorbic acid. In June 1982, the US FDA officially approved natamycin as a food preservative and classified it as a GRAS product.
Regarding the maximum allowable usage and maximum allowable residue of natamycin as a food additive
| Food names that allow the use of this additive | Maximum allowable usage (g/kg) | Maximum allowable residue (g/kg) |
| Fermented wine | 0.01g/L | |
| Mayonnaise, salad dressing | 0.02 | Residue ≤10mg/kg |
| Fruit and vegetable juice (pulp) | 0.3 (surface use, suspension spray or soak) | Residual amount <10mg/kg |
| Fermented meat products | 0.3 (surface use, suspension spray or soak) | Residual amount <10mg/kg |
| Meat enema | 0.3 (surface use, suspension spray or soak) | Residual amount <10mg/kg |
| Western-style ham (smoked, smoked and cooked ham) | 0.3 (surface use, suspension spray or soak) | Residual amount <10mg/kg |
| Fried meat | 0.3 (surface use, suspension spray or soak) | Residual amount <10mg/kg |
| Smoked, roasted and roasted meat | 0.3 (surface use, suspension spray or soak) | Residual amount <10mg/kg |
| Sauce braised meat products | 0.3 (surface use, suspension spray or soak) | Residual amount <10mg/kg |
| Cakes and Pastries | 0.3 (surface use, suspension spray or soak) | Residual amount <10mg/kg |
| cheese | 0.3 (surface use, suspension spray or soak) | Residual amount <10mg/kg |
What is the mechanism of Natamycin?
Natamycin powder is a kind of "polyene macrolide" fungal inhibitor produced by Streptomyces natalensis fermentation, which usually exists in enol structure. Natamycin relies on its lactone ring structure to interact with sterol compounds on fungal cell membrane to form antibiotic-sterol compounds, thus destroying the structure of fungal plasma membrane. The hydrophilic part of macrolide (polyol part) forms water holes on the membrane, which damages the permeability of the cell membrane, and then causes the leakage of amino acids, electrolytes and other substances in the bacteria and the death of the bacteria. Therefore, when we treat the dough with natamycin in baked goods, we will find that it can obviously prolong the shelf life. Crucially, the cell surface of animal body is lack of sterols, so it is not sensitive to polyene antibiotics. That is to say, after we use this product, it is difficult to be absorbed by the human digestive tract. There is no risk of human mechanism mutation, carcinogenesis and sensitization. Because of this, it is also an efficient, broad-spectrum, safe and natural antifungal biological food preservative that has been unanimously recognized and approved by the international community at present.Our company can provide a large number of Natamycin raw powder that meets FDA requirements, and can apply for free samples for you according to your purchasing situation. If you are interested, please contact us by email:sales6@faithfulbio.com
Is natamycin harmful to human body?
Although natamycin is not as harmful to human body as nystatin and filipinomycin (because nystatin and filipinomycin can change the permeability of cell membrane), it is still necessary to control the intake. We think it may be because this product is difficult to be absorbed by human digestive tract, and it is also difficult for microorganisms to attack natamycin. Long-term large intake will increase the burden on the digestive system, especially for some patients with gastrointestinal diseases. Moreover, although this product has considerable product quality assurance ability, it does not mean that this product is omnipotent. After all, there are still many unknowns in the microbial world that we need to explore. Controlling the appropriate dosage also has a certain economic purpose and the need to pursue the purity of protected products.
Product Specification
| Item | Specification | Results |
| Description | White crystal powder | Confirm |
| Assay | 99.0-101.0% | 98.35% |
| Identification | IR: White crystal powder | Confirm |
| Related compounds | Any impurity ≤0.2% | 0.1% |
| Total impurities≤0.5% | 0.2% | |
| Water | ≤3.0% | 0.25% |
| Loss on drying | ≤0.5% | 0.19% |
| Heavy metal | ≤10ppm | 0.23ppm |
| Conclusion | Conforms with enterprise standards |
How can we make better use of it in our daily life?
Natamycin is an additive with high safety factor, which is mainly used to produce and process cakes and other foods, such as cheese, bread and drinks. The surface treatment of dough with natamycin in baked goods can obviously prolong the shelf life. Based on this, we summarize some routine usage methods in daily life for your reference.
1. Direct addition method: It can be applied to liquid foods such as yogurt and fresh milk or general paste or mixed foods such as sauces and fillings.
10-40 grams of natamycin and 1 liter of water are evenly stirred to make a suspension, and the suspension is added to one ton of yogurt and evenly stirred. The stirring time depends on the viscosity of the product.
2. Surface soaking method or spraying method: it can be applied to meat products, vegetarian food, cheese and other solid foods such as ham, sausage, bacon, smoked chicken, bean products or other vegetarian foods such as vegetarian chicken, gluten and dried tofu.
3. Soaking method: Soak the accurately processed food in the natamycin suspension (1-2g natamycin is added to 1 liter of 8-10%Nacl solution). The suspension needs to be stirred evenly and the temperature is kept at 20-30℃.
4. Spraying method: evenly spray the stirred natamycin suspension (3-4g natamycin is added to 1 liter of 8-10%Nacl solution) on the surface of the food to be treated.
Natamycin powder has excellent inhibitory ability to most molds and yeasts, and its low effective inhibitory concentration (MIC) is 1-10ppm. Users can choose the appropriate dosage according to the bacteria-carrying situation of the processed food. In addition, natamycin can be used to treat fungal infections and produce appropriate eye drops and Finished pills, including Candida, Aspergillus, Fusarium and so on.
A variety of shipping methods for you to choose
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China, so we can not only provide customers with the required Natamycin products, but also support the development and provision of new products.
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.
Disclaimer: The information published on this website comes from the internet, which does not mean that this website agrees with its views or confirms the authenticity of the content. Please pay attention to distinguish it. In addition, the products provided by our company are only used for scientific research. We are not responsible for the consequences of any improper use.
If you are interested in our products, or have critical suggestions on our articles or are not completely satisfied with the products received, please contact us by Email ：sales6@faithfulbio.com . Our team is committed to ensuring the complete satisfaction of customers.
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