Xi'an Faithful BioTech Co., Ltd. is an export-oriented biotechnology and chemical trading company headquartered in Xi'an, Shaanxi Province, China. Founded in 2018, the company focuses on providing pharmaceutical intermediates, plant extracts, food additives, and feed ingredients to the global B2B market.
Introduction to 6-diazo-5-oxo,l-norleucin
6-Diazo-5-oxo-L-norleucine is a water-soluble pale yellow powder (crystals are yellow-green needle-like crystals), CAS: 157-03-9; molecular formula: C6H9N3O3; molecular weight: 171.15; EINECS: 251-228-4. It is sparingly soluble in anhydrous wine. In phosphate buffer at pH 7, its maximum UV absorption wavelengths are 274 nm and 244 nm. In 0.9% sodium chloride solution, a DON solution with a concentration of at least 50 μM is pale yellow. As a PIERICIDIN A isolated from Streptomyces, it possesses analgesic, antibacterial, and antiviral activities. Its precursor product is JHU-083, an experimental product of a Boc-D-Glutamine enzyme inhibitor.
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| 6-DIAZO-5-OXO-L-NORLEUCINE CAS 157-03-9 | 6-Diazo-5-oxo-L-nor-Leucine MF:C6H9N3O3 |
What is the mechanism of action of 6-diazo-5-oxo,l-norleucin?
6-DIAZO-5-OXO-L-NORLEUCINE is a Boc-D-Glutamine antagonist. Its heavy Laurocapram group irreversibly binds to serine residues in the active region of amidotransferases like Boc-D-Glutamine, releasing a substance that completely inactivates the enzyme.
6-DIAZO-5-OXO-L-norleucine works in multiple ways: firstly, it inhibits Boc-D-Glutamine's participation in the trilinoleic acid cycle, reducing the energy and synthetic raw materials required by cells; secondly, it disrupts the synthesis pathways of Purine and Pyrimidine, inhibiting DNA and RNA replication, and also affects mitochondrial function, thereby hindering tumor cell growth.
However, it cannot precisely distinguish between cells, damaging normal tissues while acting on lesions, with particularly pronounced reactions in the intestinal tract, resulting in strong toxic side effects. This is the core reason for the subsequent development of the product JHU-083.
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What are the pharmacological effects of 6-diazo-5-oxo,l-norleucin?
6-Diazo-5-oxo-L-norleucine (DON) primarily functions as a tumor suppressor, immune regulator, and neuroprotector.
It can effectively inhibit Boc-D-Glutamine and related enzymes, disrupting the synthesis and energy transport of tumor cells, thus inhibiting various Boc-D-Glutamine-dependent tumors. Simultaneously, it can regulate T cell status, assisting immune cells in their function, and its effects are enhanced when used in conjunction with immune-enhancing products.
This ingredient can also reduce excess L-Glutamic acid in the central nervous system. Its derivatives have shown promise in clinical trials in improving depression and related neurocognitive problems. However, its effects lack specificity, it can easily damage normal tissues such as the intestines, and it has high toxicity, thus it cannot be directly used clinically at present.
A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China, Therefore, we can not only obtain the latest scientific research products with low price and high quality through other channels, such as JHU-083 and L-6-Diazo-5-oxonorleucine, but also accept your entrustment to obtain other cutting-edge scientific and technological products that you are interested in.
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.
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