6 Diazo 5 oxo L norleucine CAS 157-03-9

6-Diazo-5-oxo-L-norleucine is a water-soluble pale yellow powder (crystal form is yellow-green needle) soluble in methanol, acetone or ethanol, but it is difficult to dissolve in anhydrous wine. In phosphate buffer with pH 7, the maximum ultraviolet absorption is 274 nm(E1%1 cm. 683) and 244 nm(E1%1 cm 376). In 0.9% NaCl, the solution of at least 50 μM DON is pale yellow. As an antibiotic isolated from Streptomyces, it has analgesic, antibacterial, antiviral and anticancer properties. Its precursor product is JHU-083, an experimental product as a glutaminase inhibitor.

What is JHU-083?

JHU-083 (Ethyl 2-(2-Amino-4-methylpentanamido)-DON) is a novel precursor product for DON. It belongs to the experimental product of glutamine enzyme inhibitor and has not yet been mass-produced, so it needs to be prepared and used on site. Under the latest research findings, we found that it can be cleaved into the active form 6-Diazo-5-oxo-l-norleucine in mice, selectively blocking the activity of glutaminase in brain CD11b+cells. In the comparison of animal behavior models, we found that before using this product, animals exhibited a very solitary and depressed behavior (Including often staring blankly in a narrow space, and frequently hitting the wall with your head.) and strong aggression (including attacking their peers and caretakers), which is similar to the well-known bipolar disorder. After using this product, animals exhibit mild and sociable behavior, and their aggressive behavior becomes less and less frequent. Based on a large amount of data comparison, we believe that JHU-083 has the ability to improve depression related behaviors caused by chronic

social frustration stress.JHU-083 and 6-DIAZO-5-OXO-L-NORLEUCINE are newly developed products of our company. If you are interested in them, please leave us a message through email:sales6@faithfulbio.com.

What are the pharmacological effects of this product?

6-Diazo-5-oxo-L-norleucine (DON) is a glutamine antagonist, and due to its similarity to glutamine, it is also a cytotoxic inhibitor of various nucleotide synthases. In 2019, animal model studies showed that when combined with a calorie restricted ketogenic diet, DON can kill tumor cells, reverse disease symptoms, and improve overall survival in mice with advanced experimental glioblastoma. However, it should be noted that DON has not yet been approved as a drug or subjected to more detailed product experiments. We can only speculate that DON enters the catalytic centers of these enzymes through its similar glutamine structure and inhibits them through covalent binding (or more accurately, through alkylation).

A variety of shipping methods for you to choose

Our strengths:

Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China, Therefore, we can not only obtain the latest scientific research products with low price and high quality through other channels, such as JHU-083 and L-6-Diazo-5-oxonorleucine, but also accept your entrustment to obtain other cutting-edge scientific and technological products that you are interested in.

We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.

Disclaimer: The information published on this website comes from the internet, which does not mean that this website agrees with its views or confirms the authenticity of the content. Please pay attention to distinguish it. In addition, the products provided by our company are only used for scientific research. We are not responsible for the consequences of any improper use.

If you are interested in our products, or have critical suggestions on our articles or are not completely satisfied with the products received, please contact us by Email ：sales6@faithfulbio.com   . Our team is committed to ensuring the complete satisfaction of customers.

Hot Tags: 6 Diazo 5 oxo L norleucine CAS 157-03-9, China, suppliers, manufacturers, factory, customized, wholesale, buy, price, bulk, pure, producer, discount, for sale, in stock, free sample, raw powder, raw material, made in China