Mulberry extract mainly contains functional components such as polyphenols and polysaccharides. In recent years, the pharmacological studies of mulberry, a traditional Chinese medicine, have focused on immune regulation, anti-oxidation, anti-cancer and other aspects, especially on the mechanism of anti-oxidation and its correlation with active Active ingredient.
The immunomodulatory effect of this product
The material basis of mulberry immune regulation is mulberry polysaccharides. Research has found that mulberry water extract is a new activator of receptor TLP4, which can induce the immune response of Th1 cells and regulate immune function. The ethanol solution and insoluble substance of mulberry were respectively studied for immune regulation in vitro, and it was found that the ethanol solution of mulberry had a good ability to inhibit abdominal inflammation, regulate the activation of spleen cells, and make immune cells incline to Th2 immune response. Mulberry ethanol insoluble substances have significant anti-inflammatory effects in vitro experiments, with their main components being polysaccharides and proteins. Therefore, this may be a potential immunoactive component in Mulberry. Further research has found that mulberry polysaccharides have the potential to regulate Th1 immune tendency and have an impact on changes in splenic lymphocyte composition.
What is protecting nerve cells?
Mulberry anthocyanins and Oxyresveratrol have good protective effects on the nervous system, and are expected to become the basic drugs for the treatment of Parkinson's syndrome. Recently, it has been found that mulberry can protect dopaminergic neurons in Parkinson's disease models caused by toxins, which may be helpful in preventing and treating Parkinson's syndrome. The experiment confirmed that Oxyresveratrol in mulberry can inhibit the neurotoxicity of Parkinson's disease model. The protective effect of mulberry extract on PC12 cells in hydrogen peroxide environment was studied, and it was found that the extract had protective effect on PC12 cells in simulated ischemia and glucose deficiency. At the same time, the experiment with mouse cerebral ischemia model confirmed that Cyanidin 3-O-glucoside in mulberry anthocyanins could provide protection for neurons in cerebral ischemia.
Can antioxidant effects work?
Mulberry polysaccharides contained in mulberry have scavenging effects on hydroxyl radicals and superoxide anion radicals, blocking the free radical reaction chain, and have certain antioxidant and anti-aging effects. Mulberry extract is rich in phenolic substances and pigments, which can significantly improve antioxidant enzyme activity and delay memory decline during aging.
Research has shown that its antioxidant ability is closely related to the content of anthocyanins and other substances. Mulberries rich in anthocyanins can enhance the antioxidant and cognitive abilities of premature aging mice, helping to prevent Alzheimer's disease. The antioxidant capacity of mulberry pigment in vitro was studied. The in vitro test showed that the extract of mulberry pigment had a certain inhibitory effect on Lipid peroxidation, and had different degrees of scavenging effects on · OH, DPPH, and ABTS+, showing a strong antioxidant capacity. It was further clarified that the scavenging capacity of hydrogen peroxide free radicals in mulberry was related to the content of total phenols, anthocyanins and Proanthocyanidin.
How does it protect the cardiovascular and cerebrovascular systems while preventing cancer?
Mulberry Anthocyanidin can enhance the activity of antioxidant enzymes in the body, inhibit lipid peroxidation, and has obvious anti-aging effect. At the same time, long-term use can also effectively prevent Atherosclerosis and protect the cardiovascular and cerebrovascular systems. Studies have found that mulberry anthocyanins can inhibit the oxidation of low-density lipoprotein, and Oxidation state low-density lipoprotein will induce macrophages to form Foam cell, leading to Atherosclerosis. The hypoglycemic effect of mulberry polysaccharides can also dilute excess sugar in the blood, reducing blood burden.
Mulberry anthocyanins can effectively slow down the metastasis and invasion of cancer cells. Researchers have studied the anti metastasis effect of mulberry anthocyanins on cancer cells and unanimously believe that it is a potential anticancer drug. The results show that mulberry anthocyanins can effectively inhibit the metastasis of melanoma, which is related to the Ras/PI3K sign and it is pointed out that mulberry may become a tumor cell metastasis suppressor.
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