What Is Lipase? （Part One）

Lipase powder is an enzyme that can hydrolyze long-chain fatty acid triacylglycerol, mainly secreted by the pancreas. The stomach and small intestine can also produce a small amount of lipase, so it is also known as pancreatic lipase. The catalytic site of pancreatic lipase is mainly composed of Catalytic triad, namely Histidine, Tryptophan and Aspartic acid. At present, we have not found the inhibition of serum on pancreatic lipase. Compared with trypsin, which is a Serine protease, the serum contains antithrombin III and is a Serpin. Therefore, serum can inhibit the Digestion of trypsin.

What are the characteristics of enzymes?

Enzymes that exist in different organisms are adapted to different environments. For example, the pH of human blood is weakly alkaline, and there are many enzymes working in the blood, while gastric juice is acidic. There are also many enzymes working in the blood, which is the pH value they are adapted to.
Human is a Warm-blooded, and most enzymes in the body work at different temperatures than those in cold-blooded animals.
Of course, this is also related to the role of enzymes themselves, such as blood flowing in the body and quickly clotting outside the body, which is the function of a certain enzyme at work.

Lipase is widely present in animals, plants, and microorganisms. Firstly, plants such as castor beans and rapeseed contain a large amount of lipase. When seeds germinate, lipase, together with other enzymes, catalyzes the decomposition of oil to produce sugars required for seed rooting and germination, providing energy for seed rooting and sprouting.
Secondly, the pancreas and adipose tissue of higher animals have a higher content of lipase in their bodies, with a small amount of lipase in their intestinal fluid. A small amount of lipase controls the digestion and absorption, fat reconstruction, and lipoprotein metabolism processes in the animal body. Finally, the lipase content in bacteria, fungi, and yeast is more abundant, suitable for industrial production and obtaining high-purity oxygen. Therefore, microbial lipase is an important source of industrial lipase.

How can we use lipase to determine abnormalities in the body?

Carbohydrates and fats provide energy and heat for our bodies. Protein is broken down into a variety of amino acids through the Decomposition of enzymes in the stomach. These amino acids are reconstituted in the human body to form various proteins needed by our body to form our body. The essence of lipase is protein, so the enzyme that catalyzes lipase hydrolysis is protease. Lipase can help break down fatty foods, and it belongs to a type of enzyme in the human digestive system. As we mentioned earlier, lipase is usually secreted by the pancreas, and a small amount of lipase is usually secreted in the stomach and small intestine. It is filtered through the glomerulus and fully absorbed by the renal tubules, so there is no lipase in normal human urine. The same goes for blood. If the lipase levels in the blood and urine increase, it indicates digestive tract disease. Such diseases as acute Chronic pancreatitis, acute Cholecystitis, Bowel obstruction, gastric and duodenal ulcer, acute Cholecystitis, hepatitis, etc. (which need to be confirmed by combining clinical symptoms and other examinations) are as follows:

Firstly, monitoring and differential diagnosis of acute pancreatitis.
Second, Chronic pancreatitis.
Thirdly, pancreatic duct obstruction.
Fourthly, examination of abdominal diseases involving the pancreas.
In general, the most common cause of lipase elevation is pancreatic diseases, including acute pancreatitis and Chronic pancreatitis. Among them, lipase begins to rise 4 to 8 hours after the onset of acute pancreatitis, reaches a peak at 24 hours, and can last for 10 to 15 days.
In addition to pancreatic diseases, common peptic ulcer perforation, Bowel obstruction, and acute Cholecystitis may also cause a slight increase in lipase.

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