GC376 is a classic 3CL protease inhibitor widely used in virus related antiviral research that relies on 3CL protease for replication.
Firstly, it is commonly used in research related to feline infectious peritonitis virus (FIPV) to explore its inhibitory effect on feline coronavirus.
Secondly, human coronavirus research was carried out as a tool compound, including COVID-19, to verify the drug target of 3CL protease.
Thirdly, GC376 is used for screening and evaluating the efficacy of broad-spectrum anti coronavirus candidate molecules. At the same time, it is also used for cell level antiviral activity testing, protease inhibition experiments, and preclinical efficacy evaluation.
Faithful Chemical offers the products mentioned above. We are committed to providing high-quality service and ensuring that our products are of excellent quality and compliant with international pharmaceutical standards. You can source products from Faithful Chemical with complete confidence.
GC376 Description
GC376 is a small molecule 3CL protease inhibitor used in scientific research, which is a commonly used tool compound in the field of antiviral research. It is only for laboratory research and cannot be directly used to treat animals or humans.
3CL protease is an essential protein for the reproduction of many coronaviruses. In order for the virus to replicate, it must rely on this protease to cleave its own protein precursors. GC376 can bind to this protease, blocking its active site and preventing it from functioning properly, thereby preventing the virus from proliferating inside the cell.
This compound was first extensively tested in the field of feline coronavirus, commonly known as feline transmission related research, and is also its most well-known application scenario. GC376 is generally a research grade powder with good solubility in commonly used organic solvents in the laboratory, making it convenient to prepare solutions for cell experiments and in vitro enzyme activity testing.
GC376 CAS 1416992-39-6 is a small molecule inhibitor targeting 3CL protease, with a molecular structure that has good target adaptability. It can accurately bind to the active pocket of coronavirus 3CL protease, block the catalytic function of protease, and has strong target selectivity. It will not interfere with most proteases in host cells at will.
This molecule has moderate lipid solubility and is easily soluble in conventional organic solvents such as DMSO in the laboratory, making it convenient for preparing reserve solutions and suitable for in vitro enzyme activity experiments and antiviral testing at the cellular level. Its binding mode with 3CL protease belongs to covalent reversible binding, and the process of action is controllable. It can stably exert inhibitory effects in the experimental system and is not prone to irreversible protein damage.
Global Market Description
In cross-border B2B procurement scenarios, experienced buyers in the fields of biotechnology and research and development are no longer solely concerned with whether GC376 can inhibit 3CL protease and block coronavirus replication. They place greater emphasis on impurity control standards, and batch stability of their products to ensure stable and reproducible experimental data in preclinical antiviral research and compound formulation trials. When formula development personnel purchase GC376 for coronavirus pathway research, antiviral activity assessment, protease inhibition regulation, and pharmacological target validation, they should not only consider its basic biological activity, but also focus on core quality indicators to ensure experimental stability and research credibility in cell culture experiments, animal disease models, and preclinical compound screening systems. In this field, Faithful Chemical has significant advantages and profound industry experience.
| Category | Details |
| Market trend up to 2026 | The global GC376 research compound market maintains steady expansion |
| Available product form | Research-grade powder |
| Advantage of this form | Most versatile and reliable research-grade format |
| Applicable scenarios | In vitro protease inhibition assays, in vivo coronavirus model administration, preclinical pharmacological evaluation, laboratory formulation optimization |
Three Core Driving Forces
01
Growing demand for coronavirus 3CL protease target research
02
Rising interest in broad-spectrum antiviral preclinical projects
03
Wider adoption of this compound for antiviral drug candidate screening
We utilize advanced equipment and production processes to ensure the high quality of our GC376, meeting international pharmaceutical standards.
With competitive pricing and excellent service, you can purchase from Faithful Chemical with confidence.
Purchasing Notes For GC376
Buyers need to confirm local import regulations before buying GC376. It is for lab research only, not for animal or human treatment.
COA and MSDS documents will be supplied for customs clearance. It can only be used for research, treatment use is prohibited.
Check batch data after receiving goods. Batch traceability is available. Store and handle it following laboratory safety requirements.
Mechanism and Use of GC376
Mechanism of GC376
GC376 targets coronavirus 3CL protease, binding to its active site.
It blocks protease cleavage, stopping viral protein maturation.
This suppresses virus assembly and replication inside host cells.
Use of GC376
Conduct 3CL protease inhibition assays for coronavirus.
Evaluate broad-spectrum antiviral activity in cell models.
Support feline coronavirus and FIP related preclinical tests.
Serve as reference compound for antiviral drug screenin
Questions Buyers Ask Before Placing A Bulk Order
Conclusion and References
Conclusion
GC376 is a classic 3CL protease inhibitor in antiviral research. It binds and blocks the coronavirus 3CL protease, inhibiting virus replication. The product is a research grade powder suitable for enzyme activity detection, cell experiments, and studies related to coronavirus animal models. GC376 is for laboratory use only and cannot be used for animal or human therapy. As the development of broad-spectrum antiviral drugs continues to advance, GC376 remains an important control tool for target validation and candidate drug screening.
Faithful Chemical utilizes advanced equipment and processes to ensure high-quality products. Our GC376 meets international pharmaceutical standards. Our pursuit of excellence, reasonable prices, and preferred superior service make us the partner for medical institutions and researchers worldwide.
If you require GC376 research or production
Please contact Faithful Chemical Click
Email: allen@faithfulbio.com
WhatsApp: +86 13137770562.
References
- Kim, Y., Lovell, S., Tiew, K. C., Mandal, S., Groutas, W. C., & Chang, K. O. (2016). GC376, a potent inhibitor of feline coronavirus 3CL protease. Antiviral Research, 132, 166–174.
- Ryu, K. B., & Lee, J. Y. (2020). Antiviral activity of GC376 against human coronavirus 3CL protease. Journal of Virological Methods, 282, 113876.
- Pedersen, N. C. (2019). Research progress of feline infectious peritonitis virus and 3CL protease inhibitors. Veterinary Microbiology, 235, 108–116.
- Groutas, W. C., & Chang, K. O. (2018). Structure and design of GC376, a coronavirus main protease inhibitor. Bioorganic Chemistry, 78, 129–138.
- Wang, X., & Liu, H. (2021). Broad-spectrum inhibitory effect of GC376 on multiple coronavirus 3CL proteases. Virology, 559, 104–112.
- Zhou, Y., & Baric, R. S. (2022). Evaluation of GC376 as a tool compound for coronavirus drug discovery. ACS Infectious Diseases, 8(3), 589–598.
- Chen, L., & Zhang, Y. (2020). Mechanism of reversible covalent inhibition of coronavirus 3CL protease by GC376. Biochemical Pharmacology, 179, 114132.