What is GC376 ?
GC376 is used for the diagnosis of cats. it is a 3C protease inhibitor, which was jointly developed by the University of Kansas and Wichita State University.
GC376 is a kind of compound originally developed as an antiviral medicine product, which shows remarkable activity especially in fighting Coronaviruses and Caliciviruses. In recent years, because of its potential inhibitory effect on SARS-CoV-2 (Covid-19) and other important pathogens, it has received extensive scientific research attention, and also triggered discussions about its use as a candidate drug for antiviral treatment.
| Product name |
GC376 |
| CAS | 1416992-39-6 |
| molecular formula | C21H32N3NaO8S |
| Molecular weight | 509.55 |
| Solubility | DMF：10mg/mL,DMSO：10mg/mL,PBS(pH 7.2)：10mg/mL |
| Water solubility | 1 mg/ml. |
| Storage condition | Inert atmosphere,Store in freezer, under -20°C |
What is the mechanism of GC376 ?
GC376 is a covalent inhibitor of viral protease.
1. Target: It is a vital enzyme in the process of coronavirus replication, and it is responsible for cutting virus polyprotein into functional unstructured proteins, which participate in the replication and packaging of viral RNA.
2. Mode of action
GC376 irreversibly inhibits enzyme activity by catalyzing the covalent binding of cysteine residues.This mechanism endows it with efficient and lasting antiviral ability.
What is the current status and application prospect of GC376 ?
1. The field of veterinary medicine
It is being developed as an anti-FIP drug for cats, and some routes may have entered the stage of informal or sympathetic use.
Some companies had planned to develop it into a commercial veterinary drug, but it has not been widely listed yet.
In the FIP cat treatment circle, GC376 (and its analogue GC373) is regarded as a product with "life-saving" potential.
2. Other coronavirus treatments
Because of its covalent inhibition mechanism, pharmacokinetic challenges and lagging research and development progress, its application prospect in human antiviral therapy is limited, but it still has research value.
It is still used as a research tool drug or a broad-spectrum antiviral lead compound to develop a new generation of inhibitors.
Product Specification
| Items | Specifications | Results |
|
Appearance |
White crystal or crystalline powder | Complies |
| Purity | ≥98.0% | 99.56% |
| Loss on Drying | ≤ 0.50% | Complies |
| Residue on Ignition | ≤ 0.10% | Complies |
|
Heavy Metals |
≤20ppm |
<20ppm |
|
Microbial Limit |
≤20ppm |
<20ppm |
| Conclusion: The test results are conformed to the in-house specification | ||
How and where to buy GC376 wholesale ?
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL, Germany DHL, Germany DPD, |
Suitable for under 50kg. |
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By Air |
Suitable for more than 50kg. |
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15-60 days |
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Suitable for more than 500kg. |
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FAQ:
Q1:Is GC376 effective for human COVID-19 ?
A1:In vitro experiments show that GC376 can inhibit the 3CL protease of SARS-CoV-2, so it has the potential to resist COVID-19 in theory. However, GC376 has not yet entered large-scale clinical trials, and is currently mainly used for scientific research, animal models or special case studies.
Q2: Is GC376 supported by scientific research ?
A2: Yes, a large number of peer-reviewed documents support its antiviral effect, especially in: feline infectious peritonitis, etc.
Q3: Do you have any products in stock? How long is the delivery time ?
A3: Conventional models are generally in stock and can be delivered quickly (1-3 days). For customized or special specifications, the production cycle is usually 7-15 days, depending on the order quantity. We will provide accurate delivery time after confirming the order.
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Attention: It should be noted that this product is not intended for the diagnosis, treatment, cure, or prevention of any disease. Please consult your doctor and learn about available research before use. Please do not use without authorization. This compound can only be used for research purposes. The US Food and Drug Administration has not evaluated these claims.
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