Itopride hydrochloride powder has a unique dual mechanism of action. It exerts a synergistic effect of blocking dopamine 2 (D2) receptors and inhibiting acetylcholinesterase (AchE) activity, not only stimulating the release of acetylcholine, but also inhibiting its degradation, thus exerting a promoting gastrointestinal dual dynamic effect.The mechanism of action of this product is not completely the same as other existing products. It has a remarkable effect on various symptoms caused by functional dyspepsia, such as upper abdominal discomfort, postprandial fullness, early satiety, loss of appetite, nausea, vomiting, etc. Its emergence provides a new option for the treatment of gastrointestinal motility disorders.
| Items | Standards | Results |
| Description | White to brown powder | Complies |
| Assay | ≥ 98% | 99.20% |
| Mesh Size | 100 % pass 80 mesh | Complies |
| Ash | ≤ 5.0% | 2.85% |
| Loss on Drying | ≤ 5.0% | 2.65% |
| Heavy Metal | ≤ 10.0 mg/kg | Complies |
| Pb | ≤ 2.0 mg/kg | 0.32 mg/kg |
| As | ≤ 1.0 mg/kg | 0.02 mg/kg |
| Hg | ≤ 0.1mg/kg | Complies |
| Total Plate Count | ≤ 1000cfu/g | 1.28 cfu/g |
| Yeast&Mold | ≤ 100cfu/g | Negative |
| E.coil | Negative/10g | Complies |
| Salmonella | Negative/10g | Complies |
| conclusion： | The results conform with USP34 |
What are the efficacy and side effects of Itopride Hydrochloride?
Clinical applications have shown that 98% purity Itopride Hydrochloride can promote gastrointestinal peristalsis when used to treat functional dyspepsia, thereby improving symptoms such as upper abdominal discomfort, postprandial fullness, and early satiety in patients. According to clinical statistics, the symptom improvement rate is as high as 99%, and there are basically no serious adverse drug reactions. It is a very safe and effective third-generation gastrointestinal motility drug. In addition, Itopride hydrochloride are often used to treat gastroesophageal reflux, which can improve symptoms such as heartburn, acid reflux, and upper abdominal pain in patients. If used to treat chronic gastritis, it can alleviate symptoms such as upper abdominal discomfort, bloating, and dull pain caused by chronic gastritis.
A medical team has been tracking and recording for a long time the effects of Shugan Jieyu Capsules (mainly composed of Hypericum perforatum and Acanthopanax) combined with Itopride Hydrochloride on gastrointestinal motility in patients with functional dyspepsia. It was found that the combination of the two not only effectively improves the level of corticotropin releasing hormone in patients, shortens the time for clinical symptoms to disappear, reduces patient pain, but also helps with patient prognosis recovery. This approach has high promotion value in clinical application
Pharmacological research on this product has found that
1. Block dopamine D2 receptor activity
We know that dopamine is an inhibitory neurotransmitter. Etobicolor can counteract the inhibition of dopamine on gastrointestinal motility, resulting in more pronounced gastrointestinal contractions than normal. During the interphase of digestion, Itopride Hydrochloride powder does not affect the contraction of the gastrointestinal tract compared to acetylcholine. However, metoclopramide has an antagonistic effect on dopamine during both the digestive and interphase periods, which means it can stimulate the contraction of the stomach and duodenum during both digestive and interphase periods.
2. Inhibit acetylcholinesterase activity
We know that acetylcholine is a chemical messenger (neurotransmitter) produced by nerve cells that can transmit nerve signals to neighboring nerve cells or cells in muscles and glands. Acetylcholine helps cells communicate with each other. Acetylcholine helps with memory, learning, and concentration. It also helps to control the functions of the heart, blood vessels, respiratory tract, urinary tract, and digestive organs. Acetylcholine esterase (AChE; EC 3.1.1.7) is a hydrolytic enzyme present in the gray matter, red blood cells, sympathetic ganglia, and motor endplates of the central nervous system. Its physiological function is to decompose the neurotransmitter acetylcholine into choline and acetic acid, rendering acetylcholine ineffective. And acetylcholinesterase has extremely high hydrolytic activity - one molecule of acetylcholinesterase per second can hydrolyze 25000 molecules of acetylcholine. Although the decomposed choline will re-enter the nerve endings and be synthesized into new acetylcholine molecules again. However, excessive activity of acetylcholinesterase may still lead to insufficient acetylcholine and weaken gastric motility and anti vomiting. On the contrary, the inhibitory effect of Itopride on acetylcholinesterase not only enhances gastric motility and anti vomiting, but also closely relates to the ileal contraction response.
Deliver & Shipping
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
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Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Can provide you with a good price.We are very specialized in Itopride hydrochloride powder .If you are interested in our products, please send email to: sales6@faithfulbio.com
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