Felodipine, like nifedipine, is a type of calcium channel blocker that reduces blood pressure by blocking the voltage dependent calcium ion current in vascular smooth muscle and artificially cultured rabbit atrial cells, as well as blocking potassium induced portal vein constriction in mice, thereby reducing peripheral vascular resistance. The pharmacological effects of Feiluodi are related to the dosage of the medication, accompanied by an increase in reflex heart rate. Researchers have found that in animals and humans, this product has a mild diuretic effect on reducing peripheral vascular resistance, which is beneficial for the treatment of hypertension.
|
ITEMS |
SPECIFICATIONS |
RESULTS |
|
|
Appearance |
Light yellow powder |
Complies |
|
|
Odor &Tasted |
Characteristic |
Complies |
|
|
Assay(%) |
≥98.0 |
98.65 |
|
|
Loss on Drying(%) |
≤0.5 |
0.14 |
|
|
Residue on lgnition(%) |
≤0.1 |
0.02 |
|
|
Particle size(%) |
100%through 80 mesh sieves |
99% |
|
|
Heavy Metal(ppm) |
≤10.0 |
1.38 |
|
|
Pb(ppm) |
≤1.0 |
Negative |
|
|
As(ppm) |
≤1.0 |
Negative |
|
|
Hg(ppm) |
≤0.1 |
Negative |
|
|
Cd(ppm) |
≤1.0 |
0.8 |
|
|
Microbiological Tests |
Total Plate Count(cfu/g) |
≤1000 |
2.38 |
|
Yeasts and Moulds(cfu/g) |
≤100 |
0.38 |
|
|
E.coli(cfu/g) |
Negative |
Complies |
|
|
Salmonella |
Negative |
Complies |
|
| Conclusion： |
Conform with enterprise specification . |
||
What are the pharmacological effects and mechanisms of action of Felodipine?
The main function of nifedipine is to reduce the patient's systolic blood pressure and pulse pressure, thereby improving the endothelial function of blood vessels; To the extent of anti atherosclerosis.
The mechanism of action of nifedipine is mainly twofold: ① it can lower systemic blood pressure; ② It can cause sustained dilation of the glomerular afferent arterioles. Therefore, nifedipine can increase renal blood flow and glomerular filtration rate, improve renal ischemia, and prevent disturbances in renal vascular and glomerular structure and function. In addition, by regulating the passage of large molecules through the glomerular basement membrane, the metabolic activity of residual kidney tissue is reduced to a certain extent, and the
formation of free radicals is reduced to protect the kidneys. However, the drawback of nifedipine is that it may cause functional abnormalities in patients with kidney disease.
What are the side effects of Felodipine?
Felodipine powder, as a kind of high-quality long-acting antihypertensive drug, still has some side effects: compared with nifedipine sustained-release tablets, felodipine sustained-release tablets will also increase the heart rate of patients. There is also mild to moderate ankle edema, and this phenomenon is caused by peripheral porch expansion related to drug dose; Facial flushing, headache, palpitation, dizziness and fatigue will occur at the beginning of the treatment of felodipine sustained-release tablets or when the dosage is increased, and these reactions are mostly transient; Some patients will have swollen gums after taking felodipine, and patients can solve this problem through dental treatment; As for the confusion and sleep disorder of very few patients taking drugs, the current research has not confirmed that it is related to felodipine.
A variety of shipping methods for you to choose
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide Felodipine powder etc. at a more favorable price. If you are interested, please leave a message.
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.
Disclaimer: The information published on this website comes from the internet, which does not mean that this website agrees with its views or confirms the authenticity of the content. Please pay attention to distinguish it. In addition, the products provided by our company are only used for scientific research. We are not responsible for the consequences of any improper use.
If you are interested in our products, or have critical suggestions on our articles or are not completely satisfied with the products received, please contact us by Email ：sales6@faithfulbio.com. Our team is committed to ensuring the complete satisfaction of customers.