Pregabalin belongs to non-γ- GABA receptor agonist or antagonist a new type of calcium channel regulator, which can block voltage-dependent calcium channels and reduce the release of neurotransmitters. Clinically, it is mainly used for neuralgia related to diabetic peripheral neuropathy, post-herpetic neuralgia, and adjuvant treatment of adult partial seizures, generalized anxiety disorder, and central neuralgia (including neuralgia associated with spinal cord injury, stroke, and multiple sclerosis), and fibromyalgia.
Three-step classification of painkillers
The classification of three-step painkillers requires the selection of drugs with corresponding steps for mild pain, moderate pain, severe and persistent pain. According to years of modification and improvement, this analgesic method is not only applied to the management of cancer pain but also applied to a wide range of diseases, such as acute and chronic non-cancer pain caused by degenerative diseases, musculoskeletal diseases, neuropathic pain disorders and other types of chronic pain.
1. First stage: mainly for mild pain, mainly non-opioid drugs, such as non-steroidal anti-inflammatory drugs, common ibuprofen, aspirin, etc., and acetanilide painkillers, such as paracetamol, with or without adjuvants;
2. Second stage: mainly for moderate pain, use weak opioids, such as dihydrocodeine and tramadol, with or without non-opioids, with or without adjuvants;
3. Third stage: mainly for severe and persistent pain, use more powerful opioids, such as morphine, methadone, fentanyl, oxycodone, and buprenorphine, with or without non-opioids, with or without adjuvants.
Adjuvants are also known as combined analgesics. Although they are usually used for indications other than pain treatment, these drugs have special help in various pain situations. Adjuvants include antidepressants, such as serotonin, norepinephrine reuptake inhibitors, anticonvulsants, such as local anesthetics (lidocaine), corticosteroids, bisphosphonates, etc.
How many levels of painkillers is pregabalin
Pregabalin is clinically classified as a 2-3 analgesic. Pregabalin is an antiepileptic drug and a new calcium channel regulator. It is clinically used to treat neuropathic pain, especially herpes zoster neuralgia, mild trigeminal neuralgia, pain after brachial plexus injury, etc.
When pregabalin is used in the treatment of moderate and severe pain, it can be combined with NSAIDs for pain relief of moderate pain, and it can be combined with opioids for moderate and severe pain. For some patients with cancer pain, stump pain, or pain after electric injury, pregabalin combined with opioids can be used to relieve pain. In addition, pregabalin can also be used in combination with strong opioids for patients with severe pain. The side effects of pregabalin include gastrointestinal reactions and liver and kidney damage, but they are mild.
Pregabalin is effective in treating trigeminal neuralgia in a few days
Pregabalin is generally effective in the treatment of trigeminal neuralgia in about ten days. Trigeminal neuralgia is a common brain disease, which is characterized by recurrent pain in the trigeminal nerve distribution area on one side of the face. Pregabalin capsule is a new Y-aminobutyric acid receptor agonist, which can block voltage-dependent calcium channels and reduce the release of neurotransmitters. It is mainly used for the treatment of peripheral neuralgia and adjuvant treatment, which can alleviate some seizures, such as post-herpetic neuralgia and fibromyalgia syndrome.