Lurasidone is a potent antagonist of the dopamine D2 receptor, which belongs to a new atypical antipsychotic. it can increase dopamine activity in the prefrontal cortex, so it also plays an auxiliary role in antidepressants. This product needs to be used in conjunction with psychotherapy, such as cognitive-behavioral therapy (CBT)
Why do mental diseases often use it?
Lurasidone is used to treat the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions) in adults and children 13 years of age and older. It is also used to treat depression in adults and children 10 years of age and older with bipolar disorder (manic depressive disorder; a disease that causes episodes of depression, episodes of mania, and other abnormal moods). Lurasidone is also used along with lithium (Lithobid) or valproate (Depacon) to treat depression in adults with bipolar disorder. Lurasidone is in a class of medications called atypical antipsychotics. It works by changing the activity of certain natural substances in the brain.
Scientific research theory about this product.
In a phase III clinical trial led by Stanford University School of medicine, patients with major depression with manic symptoms were randomly assigned to receive 20-60 mg of Lurasidone hydrochloride and a placebo for 6 weeks. The results showed that compared with the placebo group, Lurasidone hydrochlorides significantly improved the depressive symptoms and alleviated the condition.
In the meta-analysis of evaluating the effect of dopaminergic drugs on bipolar disorder, the researchers included 9 randomized controlled trials (a total of 1716 patients). The results showed that most dopaminergic drugs had good clinical efficacy on bipolar disorder, and there were no significant side effects of exercise or cognition.
What are the common side effects of using this product?
Common side effects of this product include lethargy, dyskinesia, nausea, and diarrhea. Serious side effects may include potential permanent dyskinesia, delayed dyskinesia, antipsychotic malignant syndrome, increased risk of suicide, angioedema, and hyperglycemia. It may increase the risk of death in older people with mental illness due to dementia. The safety of use during pregnancy is unclear.
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