Prostaglandin E1 is the main component of alprostadil, in which soybean oil, concentrated Vaseline, fatty acids, and injection tap water are added. Alprostadil is a therapeutic drug for platelet aggregation inhibition. It is a milky white milky liquid. What is the efficacy of alprostadil injection?
Clinically, how to use the alprostadil solution?
Alprostadil is a drug widely used in clinics to improve microcirculation. At the same time, it is also a drug with many adverse reactions, mainly phlebitis. In clinical use, it is found that some patients have interrupted the use of drugs due to varying degrees of phlebitis, which affects the treatment of the disease.
At present, the alprostadil injection used clinically is usually 10ug dissolved in 100ml of 0.9% sodium chloride injection, which is inconsistent with the requirements of the manual. The requirements for the usage and dosage of alprostadil injection are: once a day for adults, 1-2ml (alprostadil 5-10ug) + 10ml normal saline (or 5% glucose) for slow intravenous injection, or directly into a small pot for slow intravenous drip. Relevant literature has proved that the administration method of alprostadil is closely related to its phlebitis
Effect and function of alprostadil injection?
Alprostadil injection is a traditional Chinese medicine preparation of alprostadil for intravenous injection with liposome as therapeutic drug plasmid carrier. Due to the encapsulation of liposomes, prostaglandin E1 is not easy to degrade. It has the characteristics of targets that are easy to spread to the damaged blood vessels, so as to give full play to the effect of softening blood vessels and inhibiting platelet coagulation.
Alprostadil injection can be used to treat limb ulcers caused by diffuse aortic obstruction (venous obliterans, arteriosclerosis obliterans) and limb resting pain caused by obstruction of the microvascular circulatory system, and improve the disturbance of cardiovascular and cerebrovascular microcirculation. It is generally used as an antithrombotic treatment after visceral organ transplantation to inhibit thrombosis in transplanted blood vessels. In addition, for children with congenital heart disease and patent ductus arteriosus, it can reduce hypoxemia and maintain softened blood vessels to wait for surgery.
Alprostadil injection is not suitable for these patients with severe heart failure (heart failure), glaucoma or high intraocular pressure, and previous complications of gastric ulcer.
What is the difference between prostaglandin E1 and E2?
Prostaglandin E1 is prostaglandin, which is a bioactive substance that can be produced by many organs of the human body. For example, prostaglandin E1 can be produced in the lung, brain, heart, kidney, and gastrointestinal tract. Prostaglandin E1 was first found in the semen produced by the seminal vesicle. It is mainly vasodilation. Therefore, if it is used in the penis, it will lead to penile vasodilation, cavernous congestion, and firm penile erection, so it is often used in patients with impotence, and the effect is very good; Used in patients with thrombosis, it can dilate blood vessels and help alleviate thrombosis symptoms. Prostaglandin E2 (PGE2), also known as dinoprostone, is a natural prostaglandin that can be used as a drug. PGE2 is a drug of the oxytocin family. Binding and activating the prostaglandin E2 receptor leads to the opening and softening of the cervix and the expansion of blood vessels. It is a direct vasodilator that relaxes smooth muscle and inhibits the release of norepinephrine from sympathetic terminals.
in summary： Prostaglandin E1 is mainly used for erectile dysfunction. It is a local drug. After use, it can promote the blood supply to the cavernous body. It can improve the patient's impotence and premature ejaculation. Prostaglandin E2 is mainly used to induce labor, which can soften the uterine orifice and promote uterine contraction. The specific dosage needs to be determined according to the individual's condition, and it cannot be used blindly without permission.