Can Pregabalin Capsules be used for a long time?
Pregabalin capsule is mainly used for clinical treatment of epilepsy, post-herpetic neuralgia, and other diseases, which need long-term drug treatment. However, due to many adverse reactions to the pregabalin capsule, if patients need to take it for a long time, it is recommended to monitor their blood pressure, blood sugar, and weight regularly. As the adverse reactions are dose-dependent, pregabalin capsules are mainly excreted and cleared by the kidney. Patients with impaired renal function should adjust the dose or use alternative drugs under the guidance of doctors. In addition, because the liver function has no effect on the metabolism of pregabalin capsules, patients with impaired liver function do not need to adjust the dose.
According to clinical use, pregabalin capsules can be taken for a long time. However, the effect of any drug will decline if it is used for a long time. Alternative medicines are recommended. Therefore, it is generally not recommended to take pregabalin capsules for a long time. In the treatment of postherpetic neuralgia clinically. Doses are usually determined according to patient tolerance. The initial dose is usually 75 mg/time, twice daily. Depending on the efficacy and tolerability, it can be increased to 150 mg twice a day for a week. The drug is mainly excreted through the kidney. If the renal function decreases, the dosage should be adjusted and appropriately reduced.
In clinical application, pregabalin may also have some adverse reactions, the most common of which is dizziness, lethargy, ataxia, fatigue, abnormal thinking, blurred vision, dyskinesia, dry mouth, edema, and weight gain. Therefore, pregabalin can cause some obvious adverse reactions, which should be noted.
In addition, some people are allergic to pregabalin. Patients with right heart failure should not use it, nor should they use it if they are engaged in driving or operating machines.
It is not advisable to slam the brake when stopping the use of pregabalin!
Pregabalin is commonly used in the clinical treatment of postherpetic neuralgia, neuropathic pain related to peripheral neuropathy of diabetes, fibromyalgia, and auxiliary treatment of partial seizures. It also has effects on other pathological pain.
The therapeutic effect of pregabalin on chronic pain has received more and more attention. However, many people do not use it in a standard way. They stop taking medicine at will, which causes a great burden on the recovery of the body.
Pregabalin as a γ- Aminobutyric acid (GABA) analog can block voltage-dependent calcium channels and reduce the release of neurotransmitters. As with all antiepileptic drugs (AEDs), pregabalin was gradually discontinued to minimize the increase in the frequency of seizures in epileptic patients. After stopping pregabalin suddenly or immediately, some patients have insomnia, nausea, headache, anxiety, hyperhidrosis, diarrhea, and other symptoms. If pregabalin is discontinued, it should be gradually reduced within at least 1 week, rather than suddenly discontinued.
How to deal with drug overdose?
From clinical experience, the most frequently reported adverse events of an overdose of pregabalin include decreased consciousness, depression/anxiety, insanity, excitement, and irritability, as well as seizures and heart block. It is reported that excessive use of pregabalin alone or in combination with other central nervous system inhibitors may lead to death.
Pregabalin overdose has no specific antidote. Pregabalin can be removed by hemodialysis. The standard hemodialysis procedure can significantly remove pregabalin (about 50% within 4 hours).
Patients taking AED including pregabalin for any indication will increase the risk of suicide.
Patients receiving any AED treatment should pay attention to monitoring the occurrence or deterioration of depression, suicidal thoughts or behaviors, and other emotional or behavioral abnormalities.
Epilepsy and many other diseases using AEDs increase the risk of suicidal thoughts and behaviors due to the disease itself and incidence rate and mortality. If suicidal thoughts and behaviors occur during treatment, doctors need to consider whether these symptoms are related to the disease being treated in any patient.
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