Picamilon raw materials were invented in Russia. It is a brain function improvement drug (or called: intelligent improvement drug), which increases cerebral blood flow by strongly expanding cerebral blood vessels. Today, we will discuss this product in detail. Picamilon is a compound formed by the reaction of nicotinic acid with GABA. This product can not only cross the blood-brain barrier and activate GABA receptors to produce an anti-anxiety response. Niacin can also act as a powerful vasodilator and help raise awareness.
Research Progress on Picamilon
Research from Russia shows that Pikamilone can improve neural control, thought recovery time, blood pressure, and memory. The drug even has the benefit of treating traumatic brain injury.
A neuropharmacological screening test of Picamilon showed that it had a sedative effect at a low dose. For example, at a dose of 1 mg/kg, Pikamilone can prevent the negative consequences of emotional stress. For example, when used on experimental cats, this product can normalize anger and fear as soon as possible. Like diazepam, it has an inhibitory effect on motivational attacks related to territorial competition in rats. The study on the effect of Pikamilone powder on the intracranial self-stimulation threshold shows that at higher doses (80 mg/kg or 160 mg/kg), Picamilon can reduce the self-stimulation threshold (like amphetamine), but reduce the number of self-stimulation attempts. The stimulating effect of the drug was shown in general anesthesia in clinical experiments. For example, at a dose of 100 mg/kg, this product can reduce the sedative duration of hexobarbital sodium by 1.7 times or half the duration of thiopental anesthesia. Unlike sedative drugs (chlordiazepoxide, diazepam, temazepam), Pikamilone does not cause muscle relaxation, drowsiness, or drowsiness. Clinicians said the drug was very similar to vinpocetine (ethyl ester of nepafenac), but comparing the properties of the two compounds showed that Picamilon was better.
Mechanism of action of Picamilon and whether there are side effects?
An important role of Picamilon in the mechanism of action is its effect on the neural control of cerebral circulation. It weakens the changes of cerebral blood flow during vasomotor reflex, significantly inhibits the contractile response of blood vessels in the carotid artery and vertebrobasilar artery basin due to stimulating the afferent fibers of the somatic nerve, and gradually inhibits the tonic and reflex activities of the sympathetic nerve. Picamilon does not produce allergic, teratogenic, embryotoxic, or carcinogenic effects.
This product has carried out a lot of scientific research in Russia. The total number of patients observed was 984. The recommended dosage of Pikamilone tablet for the study is: take it 2 to 3 times a day, the dose is 0.02 to 0.05 g, and the daily dose is 0.04 to 0.3 G. The course of treatment ranges from two weeks to two months. Objective methods were used to evaluate cerebral blood movement, including ultrasonic pulse map, brain echo map, brain rheology map, ultrasonic scanning, conjunctival biomicroscopy, and EEG.
On the second or third day of treatment, patients with cerebrovascular disorders think this product is effective. In patients with acute cerebrovascular disorders, there was a significant improvement on the 4th or 5th day, and the severity of some neurological symptoms was reduced. Later, headache, dizziness, noise, and memory impairment in the brain decreased, movement and language disorders began to subside rapidly, sleep improved, irritability, emotional stress and anxiety decreased, and the speed of cerebral blood flow increased. (more than a month later) the patient's mood, speech, and memory were improved, and the levels of enzyme activities (aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase) and lactate concentration returned to normal.
On this basis, the pharmacological Committee of the Ministry of Health (Russia) recommended Picamilon for the clinical trial of cerebrovascular disorders. As a product for the relief of depression and weakness, it is very meaningful for the current tense work.
Other findings on Pikamilone
Scientists studying the effects of GABA derivatives on the development of toxic brain edema (brain fluid) have shown that a specific dose of Picamilon can prevent the development of edema. In chronic cerebral insufficiency, Picamilon improves the patient's mood and memory, reduces irritability and tears, eliminates uncontrolled self-consciousness, repairs cardiovascular and cerebrovascular diseases, and reduces metabolic disorders. In patients with memory impairment (general amnesia), significant improvements in memory and recall were observed on days 5 to 7 of treatment, and patients were able to return to general work. The mental function and motor activation of patients with debilitating anxiety and depression, including the speed of postoperative repair, concentration, emotional stability, anxiety relief, improvement of working ability, and so on, are very beneficial. The use of tricyclic antidepressants in moderate doses can be reduced. Among alcoholics, Picamilon eliminated many withdrawal symptoms, especially apathy, fatigue, and drowsiness. Patients later became calmer, less irritable and anxious, and gradually reduced their dependence on alcohol.
The information in this article comes from the Internet. See the following for some references.
^ Dorofeev BF, Kholodov LE (1991)。 [pharmacokinetics of Pikamilon in animals] (Russian). Farmakologiia i toksikologiia 54 (2): 66–9。 PMID 1884802。
^Mirzoian RS， Gan'shina TS（1989）。” [new cerebrovascular preparation Picamilon] (Russian). Farmakologia i Toksikologia 52（1）：23-6. PMID 2707413