Topiramate tablets can treat migraine. Topiramate and other drugs can control the attack by reducing the excitability of brain cells, and long-term drug accumulation cannot rule out a series of uncomfortable symptoms of drug poisoning caused by excessive blood drug concentration. More importantly, it can also cause abnormal liver and kidney functions, because any garbage in the body must be detoxified by the liver and excreted by the kidney, so the gain is not worth the loss.
Is the side effect of topiramate great?
Topiramate is a new type of antiepileptic drug. Compared with traditional antiepileptic drugs such as carbamazepine, sodium valproate, and phenytoin, its side effects are not significant. Of course, it can also be used for adults and children, depending on the individual. It is recommended to increase the dose gradually from a small dose, and maintain the use after it is adjusted to an effective dose. It also has side effects, and the relative incidence is not high. In the nervous system, drowsiness and dizziness are often caused, sometimes there are sensory abnormalities, nystagmus, attention disorder, and occasionally there are tremors, intentional tremors, mental damage, speech disorders, etc. In metabolism, it will lead to anorexia, loss of appetite, and weight loss. In terms of mental emotion, it can lead to vague consciousness, depression, or anxiety, sometimes accompanied by insomnia, large emotional fluctuations, irritability, aggressive tendencies, etc. In the gastrointestinal system, it may cause nausea, diarrhea, vomiting, constipation, dyspepsia, dry mouth, etc. Sometimes skeletal muscle is involved, causing myalgia or muscle spasms.
What is the mechanism of action of topiramate tablets?
Topiramate tablets are antiepileptic drugs, and the main effective component is topiramate. Topiramate research shows that it has certain effects on the electrophysiology and biochemistry of neurons.
First, it can block the continuous and repeated potential release of neurons, which is closely related to the time after topiramate use. Secondly, topiramate can also increase γ- Frequency of aminobutyric acid activation of corresponding receptors, γ- Aminobutyric acid is an inhibitory neurotransmitter, and topiramate enhances the inhibitory central neurotransmitter through this effect, which can enhance the inhibitory effect of the central nervous system. Then, topiramate can also reduce the role of excitatory central neurotransmitters.
In a word, topiramate has an anti-epileptic effect in various ways. Topiramate tablets can be used for patients with epilepsy in the clinic, either alone or in combination with other drugs.
Clinical considerations of topiramate
First, this drug is a new type of antiepileptic drug, which can be used to control seizures in clinical practice. It has a certain effect on partial seizures and generalized seizures. If necessary, it can be taken with the doctor's advice, generally starting from a small amount, gradually increasing the amount, and should be followed up regularly to pay attention to adverse reactions to the drug.
Second, this drug also has a certain effect on preventing migraine, which can reduce the frequency of migraine attacks. When using this drug, we must pay attention to the possibility of dizziness, lethargy, fatigue, and some obstacles to balancing function. We should pay attention to identifying these adverse reactions and regularly follow up in the outpatient department. At the same time, patients with epilepsy, in addition to drug treatment, should pay more attention to their daily lifestyles.