Vortioxetine powder is a new generation of antidepressants and has been approved by the U.S. Food and Drug Administration for the treatment of the adult severe depressive disorder. Different from other first-line antidepressants, Vortioxetine is an antidepressant that plays a therapeutic role through two mechanisms: receptor activity regulation and neurotransmitter reuptake inhibition. Its main antidepressant mechanism is related to the inhibition of serotonin reuptake and enhancement of serotonin activity by the central nervous system, but the specific mechanism is not completely clear.
The latest meta-analysis provides a reference for evaluating the effectiveness and acceptability of Vortioxetine powder. This analysis compares the treatment results of Vortioxetine with a blank control group or other antidepressants in patients with depression. By extracting and analyzing the basic characteristic parameters of clinical research, the basic parameters of subjects, intervention details, effectiveness results, tolerance results, and acceptability results. A total of 15 clinical studies and 7746 patients were included, including 7 clinical trials compared with blank control and 8 clinical trials compared with norepinephrine reuptake inhibitors.
The analysis showed that compared with Duloxetine, the drug response rate and depression scale score were relatively low, the effect was poor, but the side effects were less. Compared with venlafaxine, the effect has no obvious difference.
Pain of life
Physical suffering
The study did not compare the clinical effects of Vortioxetine with selective serotonin reuptake inhibitors. Comparing the remission rate and the severity of depressive symptoms measured by the depression scale, the results showed that the effect of Vortioxetine raw powder was significantly better than that of the blank control group, and there was no significant difference in the experimental withdrawal rate. The patients who withdrew were more due to drug side effects than no effect after drug use. Compared with other antidepressants, there was no significant difference in remission rate, but the score of evidence quality was not high. The analysis showed that the norepinephrine reuptake inhibitor was more effective in alleviating depressive symptoms as measured by the depression scale.
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