Topiroxostat Powder CAS 577778-58-6

Topiroxostat Powder is a non purine selective xanthine oxidoreductase inhibitor developed by Fuji Pharmaceutical Co., Ltd. in Japan, which selectively and reversibly inhibits xanthine oxidoreductase and reduces serum uric acid levels. Clinical studies have found that FYX-051 has significant inhibitory effects on both oxidative and reductive XORs, without any hindrance to other pyrimidine purine metabolic enzymes. Its competitive and selective inhibitory effects make it safer, stronger, and more durable in reducing uric acid.

How to choose uric acid lowering products?

There are many kinds of products to reduce uric acid, which are mainly divided into two categories: the first category is drugs to inhibit uric acid production. The second kind of drugs to promote uric acid excretion. The first one is commonly used Topiroxostat, febuxostat and allopurinol, while the second one is commonly used benzbromarone.
1.  topiloric is a new inhibitor of xanthine oxidase, which is superior to allopurinol in reducing uric acid, but lower than febuxostat. However, FYX 051 has less adverse effects on the cardiovascular system, and can reduce the hyperuricemia level of patients with chronic kidney disease stage III and gout. At present, Topiroxostat powder is the first choice for long-term treatment of hyperuricemia in clinic.
2. Febuxostat is a traditional drug for reducing uric acid, but it has obvious damage to liver and kidney function and may increase the risk of cardiovascular events. In particular, hyperuricemia is a chronic disease. Long-term use of this product requires regular monitoring of liver and kidney function and screening of heart disease. However, its effect of reducing uric acid is very fast, so it can be reduced when used.
3. Allopurinol mainly inhibits the formation of uric acid, mainly treats hyperuricemia and gout, and also has a certain effect on uric acid kidney calculi. However, this product may cause serious skin allergic reactions.
4. The mechanism of action of Exurate is to promote the excretion of uric acid. And the effect is remarkable. Generally, patients need to take it from a small dose, and the dose can be adjusted according to the patient's situation in the follow-up treatment. However, it is necessary to monitor the level of blood uric acid regularly when using it to avoid the rapid decrease of blood uric acid or the possible recurrence of gouty arthritis. During the application period, patients need to drink plenty of water to increase urine output and avoid the formation of uric acid crystals.
For patients with gout, no matter what kind of drugs are used to reduce uric acid, the serum uric acid should be controlled within 360. If there is gout stone, the uric acid should be controlled within 300, and the control of uric acid should be more personalized in combination with the doctor's advice and your own actual situation. Our company is involved in many anti-gout products. In addition to the above Topiroxostat and Febuxostat, we can also provide products such as D-Glucosamine hydrochloride, Etoricoxib, Phenylbutazone sodium and their derivatives. If you are interested, please contact us by email: sales6@faithfulbio.com as soon as possible.

Will Topiroxostat have any side effects?

Topiroxostat is a clinical product for treating gout and hyperuricemia. Like other products, it may also cause some side effects. Before deciding whether to use this product, it is very important for patients and doctors to know its possible side effects. This chapter will specifically discuss the possible side effects of Topiroxostat powder and provide relevant information to better understand and manage these potential problems.

1. Side effects of gastrointestinal reaction

Topiroxostat may cause side effects of gastrointestinal reactions, such as nausea, vomiting, diarrhea and indigestion. These side effects are usually short-lived and appear in the early stage of treatment. If these symptoms persist or worsen, patients should contact a doctor for evaluation and advice.

2. Increase liver function enzymes

Some patients reported an increase in liver function enzymes during the use of Topiroxostat. This may be due to the influence of drugs on the liver. It is important to monitor liver function, and check liver function regularly during treatment to ensure that there is no abnormality. Patients should inform their doctors immediately if liver enzymes are significantly elevated or other liver-related symptoms appear.

3. Allergic reaction

A few patients may have allergic reactions to Topiroxostat, including rash, urticaria, shortness of breath, throat tightness and facial swelling. If there is any allergic reaction, the patient should stop using drugs immediately and seek medical help.

4. Other potential side effects

In addition to the common side effects mentioned above, Topiroxostat may also cause other potential side effects, such as headache, fatigue, muscle pain and joint pain. If patients have any unusual symptoms or discomfort during the use of Topiroxostat, they should consult a doctor for further evaluation and suggestions.

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Our strengths:

Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China, Our company has participated in many anti gout development projects. In addition to the above Topiroxostat and Febuxostat, we can also provide products such as D-Glucosamine hydrochloride, Etoricoxib, Phenylbutazone sodium and their derivatives. If you are interested, please contact us.

We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.

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