Montelukast Sodium Powder CAS 151767-02-1

Montelukast sodium powder was successfully developed by Merck, Germany. It belongs to cysteinyl leukotriene receptor antagonist and can specifically inhibit cysteinyl leukotriene receptor. It is not a hormone anti-inflammatory product (it will not cause adverse effects after long-term use). It belongs to the commonly used products of bronchial asthma and allergic rhinitis in clinic. According to the clinical trial data, we will find that the therapeutic effect of montelukast sodium is very obvious and its absorption ability is relatively strong. Usually, the obvious effect can be seen after using this product for one day, and the number of asthma attacks can be reduced after taking it for a period of time.

What is cysteinyl leukotriene receptor (CysLT)?

Asthma is mainly a chronic inflammatory response caused by infiltration of inflammatory cells, and the inflammatory mediators that cause this type of inflammatory response are mainly lipid inflammatory mediators, such as leukotriene, a metabolite of arachidonic acid.
Leukotriene is an important mediator of airway inflammation caused by the action of arachidonic acid on 5-ester oxygenase. It can cause bronchial constriction and promote inflammatory response. Leukotriene can also promote the production of other important inflammatory mediators, leading to asthma. In asthma, the likelihood of developing allergic rhinitis (AR) exceeds 90%.
Cysteine leukotriene is one of the important metabolites of arachidonic acid and an important inflammatory mediator. Research has shown that cysteine leukotriene (LTC4, LTD4, LTE4) is a potent inflammatory substance released by various cells, including mast cells and eosinophils. These important pre asthma inflammatory mediators can bind to cysteinyl leukotrienes receptors (CysLT) found in the human airway, leading to various airway reactions. For example, it can increase the migration of eosinophils, increase mucus secretion, increase vascular permeability and airway wall edema, and cause bronchoconstriction. Montelukast sodium(MK-476 is one of the leukotriene receptor antagonists, which can prevent leukotriene from binding to receptors, thereby reducing inflammation.Our company is committed to developing all kinds of antagonistic raw materials for use by colleges and research institutes, including but not limited to Montelukast sodium. If you need this, please contact us by email:sales6@faithfulbio.com

Product Specification

Can montelukast sodium and loratadine be used together?

Loratadine and montelukast sodium are both antiallergic products, but their mechanisms of action are different, and their clinical efficacy and adverse reactions are also different. Reasonable use can have a good curative effect.
Loratadine belongs to the second generation of antihistamines, and its antihistamine effect is quick, effective and lasting. The main side effects are nausea, dizziness, headache, drowsiness, dry mouth, fatigue, occasional drowsiness, forgetfulness, and edema of face and extremities in the morning. But under normal circumstances, the symptoms will disappear after stopping taking the medicine. Montelukast sodium is a leukotriene receptor antagonist, which can specifically inhibit cysteinyl leukotriene receptor in airway, thus improving airway inflammation and effectively controlling asthma symptoms, with mild effect, good tolerance and mild adverse reactions.
In principle, montelukast sodium chewable tablets and loratadine can be taken together. Use together here does not mean use at the same time, it means that two product can be taken at the same time on the same day. If someone suffers from allergic rhinitis or seasonal rhinitis, and has a runny nose or even tears, the effect of taking montelukast sodium or loratadine alone may not be particularly satisfactory. It is recommended to take both products at the same time.
The simultaneous use of the two products can play a certain antiallergic role, and it is also easy to produce certain side effects, and patients may have obvious drowsiness. In this case, it is recommended not to drive or other high-level products, and wait until your physical condition returns to normal before considering driving or engaging in dangerous work such as aerial work.

Can cetirizine hydrochloride and montelukast sodium be used together?

Cetirizine hydrochloride is a safe, long-acting and highly selective histamine H1 receptor antagonist, which can inhibit airway inflammation and reduce tracheal sensitivity by specifically binding with histamine H1 receptor, thus exerting antitussive effect. Generally, This product can play a role in the treatment of allergic rhinitis, but in the treatment of cough variant asthma in children, it can be used in combination with other products to enhance the clinical therapeutic effect.
It should be noted that cetirizine hydrochloride and montelukast sodium have many adverse effects. Patients need to use this product under the guidance of a physician or mentor. When there are adverse reactions such as drowsiness, palpitation, diarrhea, etc., it is necessary to consult the doctor in time whether to stop using, and the doctor will adjust the use plan or replace other products.

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Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China, so we can not only provide customers with the required Montelukast sodium powder, but also support the development and provision of new products.
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