Ketanserin Tartrate API CAS 83846-83-7

What is KETANSERIN TARTRATE?

R 41468 was initially developed as a product for treating hypertension, but was later mostly used to promote wound healing and treat anal fissures. Currently, Ketanserin Tartrate API mainly acts on wounds, burns, ulcers, and anal fissures, essentially accelerating the regeneration of epithelial cells. It is a selective serotonin (5-HT2A) receptor antagonist. It is usually a white powder, practically insoluble in water but readily soluble in Dimethyl sulfoxide.

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What is the mechanism of action of KETANSERIN TARTRATE?  

The core mechanism of action of R 41468 is as a highly selective 5-HT2A receptor antagonist. By blocking this receptor, it plays a significant role in inhibiting serotonin-induced platelet aggregation and vasoconstriction, which is the basis for its main effects in treating hypertension and promoting wound healing. In addition, this product also has a small amount of α1-adrenergic receptor blocking activity, which can synergistically dilate blood vessels at high concentrations, further enhancing its antihypertensive effect.

Furthermore, in addition to the above-mentioned treatment-related effects, R 41468 can also act on the hERG potassium channels in the heart; however, this off-target effect may affect cardiac electrical activity, and its safety should be closely monitored in clinical use. In summary, Ketanserin Tartrate API is a product that exerts its effects through multiple targets, but its primary action is through antagonism of the 5-HT2A receptor.

What are the development prospects of KETANSERIN TARTRATE?

Ketanserin Tartrate API is currently focusing on two main applications: as a product for life science experiments and for topical wound treatment.

This substance is a commonly used experimental material in neuroscience, exhibiting highly selective antagonism against the 5-HT2A receptor. Using it, researchers can block hallucinogenic responses to hallucinogenic substances, delve deeper into the mechanisms of addiction and pain regulation, and identify key targets for the development of treatments for mental illnesses and smoking cessation. 

Secondly, in clinical use, it can promote collagen production and has good effects on the healing of various wounds such as skin ulcers, burns, and anal fissures. R 41468 also possesses potential effects such as anti-inflammatory, cardioprotective, and antioxidant/anti-aging properties, although there is still significant room for future development in these areas. It continues to play an irreplaceable role in biomedical research and specialized clinical treatment.

MF of KETANSERIN TARTRATE

CAS	83846-83-7
Molecular formula	C26H28FN3O9
Molecular weight	545.52
Melting point	183～186℃
Water solubility	Soluble to 10 mM in water
EINECS	281-062-8

Specification

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Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide Ketanserin Tartrate API etc. at a more favorable price. If you are interested, please leave a message.
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FAQ: 

Q1: What are our markets?
With superior quality and competitive price, our products not only are sold well in China, but also exported to Europe, North America, Southeast Asia, the Middle East and South Africa.
Q2: If I don't know how to use product, can you give me an instruction?
Yes, you can send email to get product label and instruction. We have professional agricultural expert working in our company and supply the application information and offer solving solution.
Q3:Can I get free sample?

If you're manufacturer or distributor in the same field with us. Welcome to request a sample. Sample is free, but express freight will be in your account. When you place order in the future, previous sample and express freight will be deducted from the cost of the order.

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