Product Introduction
sofosbuvir powder is a white solid that is soluble in DMSO (a little) and methanol (a little). This substance is a prodrug that can be metabolized into the active antiviral drug 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate, which is currently in Phase 3 clinical trials for the treatment of hepatitis C. Studies have shown that sofosbuvir is a nucleotide inhibitor of hepatitis C virus and has a selective inhibitory effect on HCV NS5B polymerase.
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| sofosbuvir powder Picture | sofosbuvir powder MF |
Product Application
sofosbuvir powder is a nucleotide prodrug targeting NS5B. It is first converted into the active drug ingredient, uridine triphosphate analog (GS-461203) in the liver, and then inhibits RNA-dependent RNA polymerase activity by binding to uridine nucleoside, and hinders the synthesis of HCV RNA by acting as a "chain terminator". NS5B polymerase is a key enzyme required for the HCV virus to synthesize double-stranded RNA from single-stranded RNA. It has three domains [thumb, fingers, and palm] and multiple allosteric sites (Thumb I, Thumb II, Palm, etc.), among which the active center is located in the palm region.
A smooth, exceptionally sensitive, correct, and extra reproducible RP-HPLC technique was developed and demonstrated to estimate Sofosbuvir (SOF) in pharmaceutical dosage formulations. This process was carried out by Agilent High-Pressure Liquid Chromatograph 1260 with GI311C Quat. Pump, Phenomenex Luna C-18 (150 mm × 4.6 mm × 5 μm) (USA), and Photodiode Array Detector (PDA) G1315D. The cell section, including acetonitrile and methanol with 80:20 v/v and solution (B) 0.1% phosphoric acid (40:60), was used for the study.
However, 10 μL of the sample was injected with a drift flow of 1 mL/min. The separation occurred at a column temperature of 30 °C, and the eluents used PDA set at 260 nm. The retention time of SOF was 5 min. The calibration curve was modified linearly within the range of 0.05-0.15 mg/mL with a correlation coefficient of 0.99 and genuine linear dating among top vicinity and consciousness in the calibration curve. The detection and quantification restrictions were 0.001 and 0.003 mg/mL, respectively. SOF recovery from pharmaceutical components ranged from 98% to 99%.
Product Specification
| Items | Standard | Result |
| Appearance | White or Off-White Powder | Conforms |
| HPLC | The retention time of test sample major peak complies to reference standard | Conforms |
| Water | No more than 1.0% | 0.003 |
| Residue on ignition | No more than 0.1% | Conforms |
| Heavy metals | No more than 20ppm | Conforms |
| Related impurities | Total impurities no more than 1.5% | 0.40% |
| Purity | No less than 98.5% | 0.996 |
| Conclusion：Conform with enterprise specification . | ||
How To Obtain Samples sofosbuvir powder?
Welcome to send an inquiry to sunny@faithfulbio.com at any time for a free sample if you need the API sofosbuvir powder.
The Best sofosbuvir powder Manufacturer And Supplier
Faithfulbio has rich experience in exporting raw materials and has established stable and long-term cooperative relations with our customers. We always put product quality and service first. If you have raw material purchasing needs, please contact us. We can confirm the order with you according to your purchase quantity. We also support our first cooperation starting from samples. In addition, our fast and safe transportation also enables you to Eliminate the trouble of customs clearance.
We have confidence in the quality of our products, but if there are any after-sales problems, we will respond as soon as possible and solve them with you in the best way.
Why Choose Faithfulbio sofosbuvir powder?
Faithfulbio specialize in sofosbuvir powder for several years, we supply products at a competitive price, and our product is of the highest quality, because we are very strict in product production and testing, and have a complete and mature system. In addition, our employees The quotation for the product is very competitive.
A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
kindly note: Use sofosbuvir powder for research purposes only. All compounds have risks. Please consult your doctor and learn about available studies before use. In addition, the above description of the compound comes from online literature. If there is any infringement, please contact us to delete it.
Where To Buy sofosbuvir powder?
Just send an email to sunny@faithfulbio.com, or submit your requirement in the bottom form, we are of service at any time!
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