Doxorubicin hydrochloride powder, orange-red crystalline powder, has hygroscopicity. Soluble in water, DMSO, tetrahydrofuran, and alcohol. Insoluble in acetone, chloroform, benzene, and ether. Solubility in water is 10mg/ml. It can be compatible with glucose and sodium chloride infusion, and can also be combined with some anti-tumor drugs. It can inhibit the synthesis of nucleic acid, the genetic material of cancer cells, and its anti-tumor spectrum is wide, and it can kill many kinds of tumor cells.
Doxorubicin hydrochloride is a chemical semi-synthetic anthracycline antibiotic. Like daunorubicin and other anthracyclines, Doxorubicin can intercalate with cell DNA and affect DNA synthesis.
What is Doxorubicin hydrochloride?
Cancer is a major disease that threatens the health and safety of human life. The struggle against cancer has never stopped since ancient times. From surgical resection to chemotherapy and radiotherapy, with the development of the times, various methods of cancer treatment are constantly being refurbished, but cancer is still one of the major causes of human death. There is a long way to go to overcome cancer.
Doxorubicin hydrochloride powder is a kind of liposome preparation, which is encapsulated in liposome by combining with the surface of methoxy polyethylene glycol. This technique, called steric stabilization or concealment, can protect liposomes from mononuclear phagocyte system (MPS) recognition, thus prolonging their time in blood circulation.
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Real shot pictures of Doxorubicin HCL powder | Doxorubicin HCl structure diagram |
How does Doxorubicin Hydrochloride work?
Doxorubicin Hydrochloride Powder inhibits DNA supercoiled topoisomerase ⅱ by intercalating and inhibiting the interaction between polymer biosynthesis and DNA. Doxorubicin prevents the double helix of DNA from closing, thus destroying the replication of DNA strands. Through embedding, Doxorubicin can also act on chromatin with transcriptional activity, resulting in histone changes. The results showed that DNA damage response, epigenome, and transcriptome were out of control in the cells treated with Doxorubicin.
Where is Doxorubicin hydrochloride applied?
1. Doxorubicin hydrochloride is an aperiodic specific anti-tumor drug with a wide anti-tumor spectrum. As a second-line anti-tumor drug, doxorubicin can be used for treatment when drug resistance is the first choice.
2. It is an anti-tumor antibiotic, which has the effect of doxorubicin in cardiac mitochondrial DNA. Inhibitors of reverse transcriptase and RNA polymerase, immunosuppressants; Can be inserted into the DNA strand.
3. It is used to inhibit macromolecular biosynthesis
4. It is a cancer chemotherapy agent, mainly used for acute and chronic leukemia and malignant lymphoma.
What are the adverse reactions of using doxorubicin hydrochloride?
Doxorubicin hydrochloride is a chemotherapeutic drug, which has strong cytotoxicity, so it does great harm to the body. Common adverse reactions are inhibition of bone marrow hematopoietic function: thrombocytopenia and leukopenia. There is delayed cardiotoxicity, and heart failure can occur in severe cases. All patients have different degrees of alopecia, which can be recovered after drug withdrawal. Gastrointestinal reaction: nausea, vomiting, abdominal pain, and intestinal ulcer of the oral mucosa. Fever, hemorrhagic erythema, and liver function damage can be seen in a few cases.
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Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure or prevent any disease.
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