Pirfenidone Powder CAS 53179-13-8

Pirfenidone powder is a chemical substance, white powder, molecular formula: C12H11NO, molecular weight: 185.222, density: 1.137 g/cm3, melting point: 96-97ºC, boiling point: 329.1ºC It is a new anti-fibrosis small molecule compound, belonging to pyridine drugs. Soluble in alcohol and chloroform, and insoluble in water, molecules passing through the cell surface do not need receptors. It was awarded the title of orphan drug by the FDA of the United States and EMA of the European Union. The world's first and only therapeutic drug to obtain the indication of idiopathic pulmonary fibrosis (IPF).

What is Pirfenidone?

An interstitial lung disease is a group of heterogeneous non-tumor and non-infectious lung diseases with inflammation and interstitial fibrosis of alveolar units as the basic pathological changes. In the acute stage, it is mainly injury or inflammation, and in the chronic stage, it is mainly fibrosis. In recent years, with the continuous progress of the medical level, the research on interstitial lung disease has become deeper and deeper, and the classification of diseases has become more and more detailed. Different types of interstitial lung disease have different diagnostic criteria and treatment schemes.

Pirfenidone powder can prevent and reverse fibrosis and scar formation; It was listed by Shionogi in 2008 and has been approved by the US Food and Drug Administration. It is the first drug that has a certain curative effect on idiopathic pulmonary fibrosis (IPF) through repeated, randomized, placebo-controlled phase III clinical trials.

Where is pirfenidone suitable for?

1. Idiopathic pulmonary fibrosis

Idio-pathic pulmonary fibrosis (IPF) is a chronic inflammatory interstitial lung disease with unknown causes, poor prognosis, and high mortality. Pirfenidone is an anti-inflammatory and anti-fibrosis agent, which can be used in the treatment of IPF.

2. Liver fibrosis

3. Renal fibrosis disease

4. Multiple sclerosis

Multiple sclerosis (MS) is an inflammatory and demyelinating disease related to the central nervous system and immunity. The related immune factors are the activation of stellate cells, glial cells, endothelial cells, and the increase of lymphocytes, while Pirfenidone has the characteristic of inhibiting cell activation.

5. Myocardial fibrosis

Cardiovascular diseases, such as hypertension, cardiomyopathy, and atrial fibrillation, can all lead to myocardial fibrosis, and then worsen or develop the disease.

6. Tumor diseases: neurofibroma, uterine leiomyoma, malignant glioma.

7. Prevention of fibrosis after organ transplantation

8. Rheumatoid arthritis

How does Pirfenidone work?

Pirfenidone powder is an effective cytokine inhibitor, which can inhibit the biological activity of fibroblasts and reduce cell proliferation and matrix collagen synthesis by regulating or inhibiting some factors. At the same time, it can also inhibit the secretion of inflammatory mediators, reduce lipid peroxidation, etc., and exert its anti-inflammatory and antioxidant effects.

1. Inhibit collagen synthesis

Pirfenidone can reduce the expression of bFGF, TGF-β, CTGF, and TIMP-1 in fibroblasts of lungs, kidneys, and other organs, and it is correlated with collagen synthesis and matrix reduction. The production of type ⅰ and type ⅲ collagen fibers is also closely related to the synthesis of matrix collagen. It can not only reduce the expression of TGF-β but also reduce the production of α-ⅰ collagen.

2. Anti-inflammatory effect

It can inhibit inflammatory mediators from exerting their anti-inflammatory effects to different degrees.

3. Antioxidant effect

It exerts its antioxidant effect by scavenging free radicals, inhibiting lipid peroxidation, and reducing oxidative stress.

What are the side effects of pirfenidone?

Pirfenidone is a drug for pulmonary fibrosis, which is mainly suitable for mild to moderate idiopathic pulmonary fibrosis. Some side effects may also occur during the use, and patients may have gastrointestinal reactions, such as nausea, indigestion, vomiting, anorexia, etc. Patients may also have allergic reactions to light, and skin rashes may occur after use. Therefore, it is recommended that patients should use sunscreen to avoid exposure to ultraviolet rays and prevent skin allergic reactions when using this medicine.

In addition, liver function may be damaged, transaminase may increase, and jaundice may also occur in patients. Therefore, patients are advised to monitor liver function regularly.

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Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure or prevent any disease.

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