Daunorubicin hydrochloride powder, a commonly used drug in the hematology department for the treatment of acute myeloid leukemia, acute lymphocytic leukemia, acute monocytic leukemia, and other diseases, is the first generation of anthracycline antibiotics. Clinically, in addition to treating acute and chronic leukemia, daunorubicin hydrochloride 23541-50-6 can also be combined with prednisone, cytarabine, or vinblastine to increase its antitumor effect. As a scientific research reagent, it is widely used in molecular biology, pharmacology, and other scientific research. For neuroblastoma and rhabdomyoma.
| Molecular formula |
|
|
|
Item |
Specification |
Result |
|
Characters |
Red to deep red solid powder |
White crystal powder |
|
Identification |
Conform |
Conform |
|
Appearance of solution |
Clear and colourless |
Clear and colourless |
|
Melting range ℃ |
≥ 190 |
191.8 |
|
Acidity |
≤1 |
<1 |
|
Related substances[Ignore(<0.05)]: |
||
|
Impurity A(%) |
≤0.1 |
Not detected |
|
Impurity B(%) |
≤0.1 |
Not detected |
|
Impurity C(%) |
≤0.1 |
Not detected |
|
Impurity D(%) |
≤0.1 |
Not detected |
|
Other single impurity (%) |
≤0.1 |
Not detected |
|
Total impurity(%) |
≤0.5 |
Not detected |
|
Heavy metals (ppm) |
≤20 |
<20 |
|
Loss on drying(%) |
≤0.5 |
0.03 |
|
Residue on ignition (%) |
≤0.1 |
0.04 |
|
Assay(HPLC) (%) |
97.0-102.0 |
99.6 |
| Conclusion： |
Conform with enterprise specification . |
What are the action mechanism and pharmacological actions of the Daunorubicin?
Daunorubicin hydrochloride powder has a cytotoxic effect and belongs to cell cycle nonspecific drug. It inserts the target cell into the adjacent base pairs of DNA to produce active free radicals, which can de spin the DNA double helix, break the DNA strand, inhibit the template activity of nucleic acid, interfere with the transcription process, prevent mRNA synthesis and achieve the replication of tissue cells. It may also cause the rupture of the cell membrane and lead to cell death, so as to exert its efficacy. As a cycle, nonspecific antitumor drug, animal tests show that it can prolong the life of mouse L1210 leukemia, and also has a certain effect on Aminofolate, 6-mercaptopurine, and 5-fluorouracil resistant cell lines. In addition, it has a life-prolonging effect on Yoshida sarcoma rats, and also shows a certain effect on cell lines resistant to cyclophosphamide, Triethylthiophosphoramide, 6-mercaptopurine, 5-Chlorouracil, mitomycin C and Chromomycin A3. The action mechanism of this product lies in the nucleic acid synthesis process of cells, which can directly bind to DNA and hinder DNA synthesis and DNA-dependent RNA synthesis reaction.
Clinical application and relevant theoretical support of this product
Daunorubicin hydrochloride powder is a cycle nonspecific antitumor drug. Animal experiments show that it can prolong the life of mouse L1210 leukemia, and also has a certain effect on the cell lines resistant to Aminofolate, 6-mercaptopurine, and 5-fluorouracil. In addition, it has a life-prolonging effect on Yoshida sarcoma rats, and also shows a certain effect on cell lines resistant to cyclophosphamide, Triethylthiophosphoramide, 6-mercaptopurine, 5-fluorouracil, mitomycin C and Chromomycin A3. The mechanism of daunorubicin action lies in the process of cell nucleic acid synthesis, which can directly bind to DNA and hinder DNA synthesis and DNA-dependent RNA synthesis. In clinical application, the concentrations in blood and red blood cells of 10 patients after intravenous injection (dissolving 40mg of the drug in 40ml normal saline) for 3 minutes were 228 & Mu respectively; G / ml and 237 & mu; g/g. Its main metabolite in the human body is daunorubicin alcohol. The total excretion rate at 24 hours was (11.8 & Plusmn; 5.1)%, including daunorubicin (6.33 & Plusmn; 2.93)%, daunorubicin alcohol (5.3 & Plusmn; 2.48)%. Its distribution half-life (T1 / 2 & alpha;) 0.07 hours; Elimination half-life (T1 / 2 & beta;) Is 2.86 hours, half-life (T1 / 2 & gamma;) 97.3 hours.
Does daunorubicin cause hair loss?
Using daunorubicin 20830-81-3 can cause urine to turn red, which may stain clothes. But please don't worry, this is only the product decomposition, not the blood. This is a normal phenomenon, and it will be relieved if it lasts only 1 or 2 days after administration. This product usually causes temporary and complete hair loss. After treatment, the hair will return to normal growth. After stopping using the drug, it may still produce some side effects that need attention. During this period, if you find the following side effects, please consult your doctor or relevant professionals immediately.
A variety of shipping methods for you to choose
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide Daunorubicin Hydrochloride Powder etc. at a more favorable price. If you are interested, please leave a message.
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