Lenalidomide 99% White Powder CAS 191732-72-6

Lenalidomide 99% white powder, molecular formula: C13H13N3O3, molecular weight: 259.26, density: 1.46g/cm3, melting point: 269-271°C, boiling point: 614.0±55.0 °C (Predicted), flash point: 325.1°C, white to yellow powder, which is an anti-tumor drug developed by Celgene Biopharmaceutical Company in the United States, with multiple effects such as anti-tumor, immune regulation, and anti-angiogenesis.

What is Lenalidomide?

Lenalidomide 99% white powder is a new immunomodulatory agent for the treatment of fatal blood diseases and cancer. Lenalidomide is a new generation derivative of thalidomide. Clinical data show that its efficacy is 100 times thalidomide, and it has not been found that its efficacy has the toxicity of causing battery change. Therefore, Lenalidomide is the most effective drug for the treatment of multiple myeloma at present, and more than 50% of patients can obviously prolong their survival time after taking this drug. At present, about 300,000 people in the world suffer from myelodysplastic syndrome, and lenalidomide is the most effective drug that can effectively treat this kind of malignant blood disease. Its strong efficacy and low toxicity are the main reasons for its popularity in the market.

In the past ten years, Lenalidomide has been successfully used to treat inflammatory diseases and cancers, among which the indications approved by FDA are: combined with dexamethasone to treat multiple myeloma (MM); As a maintenance treatment after MM who has received autologous hematopoietic stem cell transplantation. However, what many patients and friends don't know is that it can also be used for hepatocellular carcinoma.

How does Lenalidomide work?

Lenalidomide 99% white powder is an immunomodulatory drug, which has many mechanisms of action. In vitro studies, Lenalidomide has three main effects: 1) direct anti-tumor effect, 2) inhibition of angiogenesis, and 3) immunomodulation. In vivo, lenalidomide directly or indirectly induces the apoptosis of tumor cells by inhibiting the support of bone marrow stromal cells, anti-angiogenesis and anti-osteoclast, and immunomodulatory activity. At the molecular level, lenalidomide has been proved to interact with ubiquitin E3 ligase and target this enzyme to degrade Ikaros transcription factors IKZF1 and IKZF3.

What are the precautions for using Lenalidomide?

① May lead to birth defects;

② There may be toxic reactions in hematology;

③ It may cause deep venous thrombosis and pulmonary embolism. Because the chemical structure of lenalidomide is similar to thalidomide, and the latter is a familiar teratogenic drug, taking lenalidomide by pregnant women may also lead to birth defects or even death.

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Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure or prevent any disease.

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