what is Cabazitaxel?
Cabazitaxelis a microtubule inhibitor that is suitable for use in combination with Prednisone or Prednisolone to treat hormone refractory metastatic prostate cancer patients who have previously been treated with Docetaxel containing regimens. It achieves more precise treatment throughout the entire treatment process. It works by disrupting the microtubule network that is crucial for mitosis and interphase cell function, causing inhibition of cell division and cell death. It has been shown that Jevtana inhibits cell division and tumor cell proliferation by binding and stabilizing microtubule proteins, which are proteins in the microtubules of cells that provide the skeleton to maintain cell shape.
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Product name |
Cabazitaxel |
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CAS Number |
183133-96-2 |
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Molecular formula |
C45H57NO14 |
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Molecular weight |
835.93 |
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EINECS Number |
680-632-7 |
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Storage condition |
Sealed in dry,Store in freezer, under -20°C |
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Appearance |
white powder |
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Melting point |
180 °C | |
| Boiling point | 870.7±65.0 °C(Predicted) | |
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Solubility |
Soluble in chloroform (small amount), DMSO (small amount), methanol (small amount) |
What are the physical and chemical properties of Cabazitaxel?
Cabazitaxel is a white or off white powder. Kabatasis is almost insoluble in water, while Cabazitaxelis soluble in ethanol. The solubility of Cabazitaxel, its solubility in water, its solubility in physiological saline, its solubility in PBS buffer, its solubility in organic solvents such as DMSO and ethanol, its application in cell experiments, and its application in animal experiments such as rats.
What symptoms is Cabazitaxel suitable for?
Cabazitaxel is a microtubule inhibitor used in combination with Prednisone or Prednisolone to treat hormone refractory metastatic prostate cancer patients who have previously been treated with Docetaxel containing regimens. Jevtana can inhibit cancer cell growth and even cause cancer cell death. Clinical trials have shown that it can also cause tumor shrinkage, slow down tumor growth or spread, alleviate symptoms of prostate cancer, and improve patients' quality of life.
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Product Specification
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Items |
Standard |
Result |
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Appearance |
White or almost white powder |
white powder |
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Identification A(IR) |
IR spectrum exhibits maxima at the critical wavelengths observed for a similar preparation of a standard. |
Conforms |
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Identification B(HPLC) |
The RT matches that observed for the chromatographic analysis of the standard. |
Conforms |
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Solubility |
Soluble in chloroform (small amount), DMSO (small amount), methanol (small amount) |
Conforms |
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Loss on drying |
1.0% max |
0.5% |
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Assay(on the dried basis) |
≥98.0% |
99.1% |
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Residual Butyl Acetate |
0.5% max |
0.08% |
Conclusion：Conform with specification and qualified.
how about studies of Cabazitaxel ?
Western blot analyses for Brachyury and AR expression in prostate cell lines treated with Docetaxel (Doc) or with Cabazitaxel (Cab). Graphs represent the densimetric semi-quantification of western blot images.In Vitro
The cytotoxicity of cabazitaxel (100 μg/mL) on 4T1 cells without irradiation is 70.8%. Cabazitaxel (100 μg/mL) exhibits a concentration-dependent antiproliferation effect, with the antiproliferative activity of 56.2%
In Vivo
Cabazitaxel (10 mg/kg, i.v.) has certain toxicity to liver and kidney but it can be avoided by integrated into Ans. The body weights of mice treated with AN-ICG-CBX and AN-CBX have a slightly decrease, while body weights of the free CBX group significantly decrease compared to the control group
(Faithful has not independently confirmed the accuracy of these methods. They are for reference only)
What are the pharmacological effects of Cabazitaxel?
The anti-cancer mechanism and characteristics of Cabazitaxel are similar to those of docetaxel, and Cabazitaxel belongs to the class of microtubule inhibitors. Cabazitaxel promotes the assembly of microtubules by binding to microtubules, while also preventing the disintegration of these already assembled microtubules. Cabazitaxel stabilizes microtubules, which in turn inhibits cell mitosis and interphase cellular functions.
How and where to buy Cabazitaxel wholesale?
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A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL, Germany DHL, Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
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Note: The product is for research use only and is not intended for diagnosis, treatment, disease prevention, etc.
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