Raw Material Vincristine Sulfate CAS 2068-78-2

Raw material Vincristine sulfate is a cell cycle-specific antitumor drug of Catharanthus roseus alkaloids in the oleander family. The target of the antitumor effect is microtubules, which mainly inhibit the polymerization of tubulin and affect the formation of spindle microtubules so that mitosis stops in the middle stage. The main component of this product is vincristine, which is an alkaloid extracted from the Catharanthus roseus of the oleander family. This product is widely used in chemotherapy to treat a variety of cancers, including acute lymphoid leukemia, acute myeloid leukemia, Hodgkin's lymphoma, neuroblastoma, and small cell lung cancer.

What is the function and efficacy of vincristine?

Raw material Vincristine sulfate is an effective component extracted from Vincristine Sulphate. It has an anti-tumor effect, inhibits tumor cell mitosis, and interferes with protein metabolism. It is mainly used for treating acute leukemia, Hodgkin's disease, malignant lymphoma, and also for breast cancer, bronchopulmonary carcinoma, soft tissue sarcoma, neuroblastoma, etc. The adverse reaction to the drug is mainly nervous system toxicity, which is related to the accumulation of drugs. It will mainly cause peripheral nerve symptoms, such as numbness of fingers and toes, dull or disappearance of tendon reflex, peripheral neuritis, abdominal pain, constipation, anesthetic intestinal obstruction, etc. Motor nerve, sensory nerve, and brain nerve may also be damaged by the drug and produce corresponding symptoms, which should be paid attention to. Neurotoxicity often occurs in patients over 40 years old. Children have good tolerance. The tendency of neurotoxicity in patients with malignant lymphoma is higher than that in patients with other tumors. The adverse reactions of the drug include bone marrow suppression and gastrointestinal reactions. The repeated use will cause phlebitis. If the drug leaks out of the blood vessel during use, it can cause local tissue necrosis. There will also be adverse reactions such as hair loss and blood pressure change. During the use of the drug, the peripheral hemogram, liver and kidney functions should be checked regularly, and the heart rate, bowel sound, and tendon reflex should be checked. The drug has cytotoxicity and should be used under the guidance of experienced doctors in the use of tumor chemotherapy drugs

How long does the adverse reaction of vincristine disappear?

The side effects of Raw material Vincristine sulfate range from mild to severe, including hair loss, diarrhea, fatigue, oral pain, swelling, and vision problems.

One of the common side effects of vincristine is temporary hair loss. Patients will have symptoms such as loss of appetite, nausea, weight loss, diarrhea, stomachache, and vomiting. Women may also skip menstruation.

Some symptoms are common or mild, but they are actually allergic reactions to drugs, such as swelling of the face, mouth, or throat, urticaria, and dyspnea. Other signs of infection include ulcers near the mouth, fever, and chills. In case of allergy or infection, see a doctor immediately.

Severe Vincristine Sulphate side effects require urgent treatment, such as dyspnea, dizziness, physical pain, numbness, constipation, severe abdominal spasm, bladder problems, or seizures. In addition, daily activities such as vision, hearing, attention, walking, swallowing, and talking may also be affected and become difficult. It is important to observe whether there is redness, pruritus, pain, or burning at the use point.If it is serious, you need to see a doctor as soon as possible.

Can vincristine be replaced by Vinoresin? How to convert?

Vinblastine antitumor drugs are a class of alkaloids with anticancer activity isolated from Catharanthus roseus, a plant of the oleander family, including Vinblastine sulfate (VLB), Vincristine sulfate (VCR), Vinoresin (VDS), and Vinorelbine tartrate (NVB). Vinoresin will be used instead of vincristine in the clinic.

Can vincristine be replaced by VDS? The following principles should be considered in the composition of the combined chemotherapy regimen: 1 The drugs constituting the combined chemotherapy regimen should be effective for this kind of tumor when used alone; 2. Several drugs with different mechanisms of action and different phase selectivity of cell cycle should be selected as far as possible to form a combined chemotherapy regimen, so as to give better play to the synergistic effect; 3. The combination of drugs with different types of toxicity should be selected as far as possible, so as not to make it difficult for patients to tolerate the toxicity of each drug; 4. The designed combined chemotherapy regimen should undergo strict clinical trials to prove its clinical value.

Firstly, the main toxicity of vincristine is nervous system toxicity, and bone marrow suppression is mild; Changchun digoxin is less toxic than that of bone marrow. Taking chop regimen for the treatment of non-Hodgkin's lymphoma as an example, cyclophosphamide has obvious bone marrow inhibitory toxicity, doxorubicin has obvious cardiotoxicity and bone marrow inhibition, and vincristine is mainly nervous system toxicity. Vincristine has different toxicity types from cyclophosphamide and doxorubicin, and the bone marrow inhibition is mild; However, the bone marrow suppression of VDS is higher than that of vincristine, which is usually leukopenia. When combined with the bone marrow suppression toxicity of cyclophosphamide and doxorubicin, there may be adverse reactions that are difficult for patients to tolerate. Secondly, the clinical value of combined chemotherapy should be proved by strict clinical trials. After replacing a drug in the chemotherapy regimen, its effectiveness and safety should still be proved by strict clinical trials. After consulting, only some literature suggests that VDS can be used to replace vincristine to form a combined chemotherapy scheme, and no large-scale randomized controlled clinical trials, meta-analyses, and systematic evaluations on this problem have been found. In addition, vincristine is selectively concentrated in cancer tissues in vivo, which can synchronize proliferating cells and increase the efficiency of antitumor drugs. When vincristine is combined with methotrexate, it can prevent methotrexate from exuding from cells and increase the intracellular concentration of the latter. In view of the above three points, from the perspective of chemotherapy drug toxicity, evidence-based medicine, and pharmacokinetic characteristics, it is not recommended to use VDS instead of vincristine to form a combined chemotherapy scheme with other chemotherapy drugs.

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