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Ponatinib Powder CAS 943319-70-8

Ponatinib Powder CAS 943319-70-8

Product Name:Ponatinib powder
CAS NO.: 943319-70-8
Molecular Formula:C29H27F3N6O
EINECS.NO:1308068-626-2
Synonym:AP24534(Ponatinib);AP24534;PONATINIB;Ponatinib;CS-165
Test Method:HPLC/UV
MOQ & Package: 10g,100g,1kg etc Sub-package
Certificate：FDA,ISO,COA, HPLC, MSDS,TDS etc
Lead Time: 1-3 days
Shipping: DHL,Germany DHL,Germany DPD,UPS,USPS,FedEx,EMS,By Air,By Sea etc
Store & Shelf life; Cool & dry place;36 months
Other:There are warehouses in the United States, Australia and Germany.
Send Inquiry
Description

Overview of Ponatinib powder：

Ponatinib powder is an anticancer drug. It was approved by FDA in December, 2012, and used to treat adult chronic myeloid leukemia (CML) and Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia (ALL).

Ponatinib powder is a yellow powder, which is soluble in DMSO (up to 50mg/ml) or ethanol (up to 25mg/ml). It has good stability and can be stored in DMSO or ethanol solution at-20 for up to 3 months.

 

Structural formula of ponatinib
Product name Ponatinib powder
CAS 943319-70-8
Molecular formula C29H27F3N6O
Molecular weight 532.56
EINECS  Number 1308068-626-2
Melting point >175°C (dec.)
Acidity coefficient (pKa) 12.99±0.70(Predicted)
Solubility Soluble in DMSO (up to 50mg/ml) or ethanol (up to 25mg/ml).
Appearance Yellow powder
Storage condition -20°C
Density 1.3

What is Ponatinib powder?

Ponatinib powder is an anticancer drug. It was approved by FDA in December, 2012, and used to treat adult chronic myeloid leukemia (CML) and Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia (ALL).

Ponatinib was approved by FDA in December 2012.

What kind of patients can Ponatinib treat?

Ponatinib is mainly used to treat patients who have no response to dasatinib or nilotinib, or patients who cannot tolerate dasatinib or nilotinib, and patients who are not suitable for subsequent treatment with imatinib.

It can also be used to treat patients with gene mutation ("T315I mutation"), which makes patients resistant to imatinib, dasatinib or nilotinib. Ponatinib is also used to treat CML and Ph+ALL in adults who have not been treated with other TKIs.

Ponatinib is the only effective drug for mutation of Bcr-Abl kinase T315I.

Ponatinib is the only effective drug for mutation of Bcr-Abl kinase T315I. Ponatinib was approved in July 2013 in the European Union through a centralized approval process. It is the third generation of multi-target tyrosine kinase inhibitors. The typical drugs of multi-target tyrosine kinase inhibitors are sunitinib, imatinib, sorafenib and vataranib.

On November 22, 2013, the European Medicines Agency (EMA) released a message that the Committee for Medicines for People (CHMP) proposed to update the use of Ponatinib to help patients minimize the risk of blood clots blocking arteries or veins.

Ponatinib was approved in the EU in July 2013.
 

product Specification

Item Specification Results

Appearance

  Light yellow solid powder Complies
Identification By IR Complies

 

 By HPLC Complies

Loss on drying(%)

  ≤1.00% 0.85%
Heavy Metals ≤20ppm Complies
Residue on Ignition ≤0.20% 0.09%
Related Substance Any single impurity: ≤0.50% 0.10%
  Total Impurities: ≤1.00% 0.30%
Assay(HPLC basis on drying) 98.0%~102.0% 99.25%
Conclusion: The test results are conformed to the in-house specification  
 

What is the therapeutic effect of Ponatinib?

1. Therapeutic effect of lymphoma Ponatinib has shown remarkable efficacy in the treatment of lymphoma. Lymphoma is a malignant tumor that affects the lymphatic system. Patients usually have symptoms such as swollen lymph nodes and fatigue. Studies have shown that ponatinib shows excellent anti-tumor activity in the treatment of relapsed or drug-resistant lymphoma patients. By inhibiting the growth and diffusion of diseased cells, it blocks related signal transduction pathways, thus alleviating symptoms and improving survival rate.

2. Therapeutic effect of leukemia Ponatinib also showed a good therapeutic effect in the treatment of leukemia. Leukemia is a malignant disease with excessive growth of white blood cells in bone marrow, which seriously affects the hematopoietic function of patients. Studies have shown that ponatinib can significantly improve the survival rate and prognosis of certain subtypes of leukemia, such as chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). It can effectively control the progress of the disease by specifically inhibiting the mutation of related causes and causing apoptosis of tumor cells.

3. Therapeutic effect of pleural mesothelioma Ponatinib is also used to treat pleural mesothelioma, which is a common malignant pleural tumor. Its main symptoms include dyspnea, chest pain and pleural effusion. It was found that ponatinib showed certain effect in the treatment of pleural mesothelioma. It can interfere with the proliferation and migration of tumor cells by inhibiting specific signal pathways, thus alleviating symptoms and prolonging the survival of patients.

To sum up, Ponatinib has attracted much attention in the treatment of lymphoma, leukemia and pleural mesothelioma because of its excellent therapeutic effect. Its specific inhibition of etiological mutation and interference with signal transduction of tumor cells make it one of the important drugs in the field of anti-tumor therapy. As a drug therapy, ponatinib also has certain side effects and safety risks, so it is necessary to strictly follow the doctor's advice and closely monitor the patient's condition and adverse reactions to ensure safe and effective treatment.

 

How and where to buy Ponatinib powder wholesale?

You can trust us completely because we have a good record in selling legal education drugs. Over the years, we have reached Many orders cooperation between Europe and America, which is safe and fast. Have safeguard.

Reasons for choosing us: reliable strength supply, high quality and stable storage, worry-free supply and timely delivery after sale.

 

Send your Inquiry for more details, Click email：sales7@faithfulbio.com Now.

 

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A variety of shipping methods for you to choose

Transportation Time

Shipping method

Cargo weight requirements

 Advantage

3-7 days

DHL,Germany DHL,Germany DPD,
UPS,USPS,FedEx,TNT,EMS

Suitable for under 50kg.
International door to door express

We have warehouses in Germany and California, USA,
and customers in Europe and America can
enjoy sending goods directly from these two places.

7-15 days

By Air

Suitable for more than 50kg.
fast and cheaper for large order

15-60 days

By Sea

Suitable for more than 500kg.
Cheapest shipping way

 

Send your Inquiry for more details, Click email:sales7@faithfulbio.com Now.

 

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Attention: It should be noted that this product is not intended for the diagnosis, treatment, cure, or prevention of any disease. Please consult your doctor and learn about available research before use. Please do not use without authorization. This compound can only be used for research purposes. The US Food and Drug Administration has not evaluated these claims.

 

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