Mitoxantrone Hydrochloride Powder CAS 70476-82-3

Mitoxantrone hydrochloride powder is an organic substance, its molecular formula is C22H30Cl2N4O6, its molecular weight is 517.4028, and its melting point is 203-205 C. Storage conditions: 2-8 C, it is used to fight cancer.

What is Mitoxantrone hydrochloride?

Mitoxantrone hydrochloride powder will enter cells through active transport or facilitative diffusion and will inhibit the conversion of dihydrofolate reductase and dihydrofolate into tetrahydrofolate after excessive polyglutamate in cells. Mitoxantrone HCl inhibits the ab initio synthesis of purine and pyrimidine, the formation of polyamines, and the transmethylation of DNA, RNA, phospholipids, and protein. Mitoxantrone HCl can also inhibit thymidine synthase, resulting in insufficient thymidine in cells, which may lead to anti-proliferation cytotoxicity.

What are the functions of Mitoxantrone hydrochloride?

Mitoxantrone hydrochloride powder binds to DNA molecules, inhibits nucleic acid synthesis, and leads to cell death. It is a cell cycle nonspecific drug. It has no complete cross-resistance with anthracyclines.

The antitumor effect of Mitoxantrone hydrochloride is five times that of adriamycin, and its cardiotoxicity is low. It can be used for treating advanced breast cancer, non-Hodgkin's disease, lymphoid tumor, and adult acute non-lymphocytic leukemia recurrence.

What precautions should be taken while using Mitoxantrone hydrochloride?

1. The hemogram should be strictly checked during use.

2. Patients with heart disease, anthracycline drugs, or chest irradiation should pay close attention to the occurrence of cardiac toxicity.

3. Care should be taken to avoid spillage of liquid medicine when taking medicine. If spillage is found, it should be stopped immediately and started again from another vein.

4. It should not be mixed with other drugs.

5. It may precipitate crystals at low temperatures, so the ampoule can be heated in hot water and used after the crystals are dissolved.

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Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure or prevent any disease.

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