Bicalutamide 99% White Powder CAS 90357-06-5

Bicalutamide 99% white powder is soluble in dimethylformamide; Dissolve in tetrahydrofuran; Slightly soluble in ethyl acetate and methanol; Insoluble in water. Crystallized from 1: 1 (volume ratio) ethyl acetate and petroleum ether, melting point 191 ~ 193℃, boiling point 650.3±55.0 °C(Predicted), density 1.52 0.1 g/cm3 (predicted).

Bicalutamide is a non-steroidal antiandrogen drug, which is used in combination with a luteinizing hormone-releasing hormone (LHRH) analog or surgical orchiectomy for the treatment of advanced prostate cancer. It has no effect on other hormones, and it binds with the androgen receptors, so it has no effective gene expression, thus inhibiting the stimulation of androgen and leading to the atrophy of prostate tumors.

What is Bicalutamide?

Bicalutamide 99% white powder is a non-steroidal androgen antagonist, which competes with androgen for the androgen receptors, blocks the uptake of androgen by cells, and inhibits the combination of androgen with target organs. After combining with the androgen receptor, it forms a receptor complex, enters the nucleus, and combines with nuclear protein, thus inhibiting the growth of tumor cells. It can be used as the first-line medicine for the palliative treatment of advanced prostate cancer.

Bicalutamide is an androgen-resistant non-corticosteroid that can be used as an adjuvant in the treatment of advanced prostate cancer, and it can also play an important role in the treatment of early prostate cancer.

Its structure is similar to that of flutamide and nilutamide. It completely inhibits the action of endogenous androgens in sensitive tissues, including the testis, prostate, breast, skin, and hypothalamus, by binding to androgen receptors in cells. Bicalutamide was approved for listing in the United States in 1995.

How does Bicalutamide work?

Bicalutamide 99% white powder is a non-steroidal antiandrogen drug, which has no effect on other hormones. It binds to the androgen receptors, which results in no effective gene expression, thus inhibiting androgen stimulation and leading to the atrophy of prostate tumors. It is a racemate, and its antiandrogen effect only appears on (R) a structural enantiomer.

Bicalutamide is an effective anti-androgen drug and a mixed-function oxidase inducer in animals. The changes in animal target organs are related to these effects, including tumor induction. In the human body, enzyme induction has not been found. The results of preclinical trials are considered to be irrelevant to the treatment of patients with advanced prostate cancer.

What are the application areas of bicalutamide?

1. It is used in combination with luteinizing hormone-releasing hormone (LHRH) analog or surgical orchiectomy for the treatment of advanced prostate cancer.

2. It is used for locally advanced prostate cancer with no distant metastasis that is unsuitable or unwilling to undergo surgical castration or other medical treatment.

3. V1 takes antiandrogen drugs. Is a drug for treating prostate cancer, and is used for treating advanced prostate cancer.

4. It is an antiandrogen.

What should be paid attention to in the use of bicalutamide?

Bicalutamide is widely metabolized in the liver. The data indicate that drug clearance may slow down in patients with severe liver damage, which may lead to accumulation. Therefore, it should be used with caution for patients with moderate and severe liver injury.

Liver changes may occur, and regular liver function tests should be considered. Major changes usually occur within the first 6 months of treatment with this product.

Severe liver function changes are rare in bicalutamide treatment. If serious changes occur, the treatment should be stopped.

It shows that it inhibits the activity of cytochrome P450(CYP3A4), so it should be used with caution when combined with drugs mainly metabolized by CYP3A4.

Pregnancy and lactation: forbidden for women, especially for pregnant women or breastfeeding mothers.

Influence on the ability to drive and operate machines: It will not affect the patient's ability to drive and operate machines.

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Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure or prevent any disease.

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