What is Levamisole hydrochloride?
In recent years, the incidence of malignant tumors in the world has increased year by year, and chemotherapy is still the main means to treat malignant tumors. Chemotherapy will lead to immune dysfunction in most patients and induce serious infections and other complications. Therefore, Levamisole hydrochloride powder is of great significance to develop drugs for enhancing immune function. Besides being often used as an insect repellent, it also has the function of immune regulation, which can effectively improve the immune function of patients. It appears as white powder, sealed and stored in a cool place (below 20℃).
| Product name |
Levamisole hydrochloride powder |
| CAS | 16595-80-5 |
| Molecular formula | C11H13ClN2S |
| Molecular weight | 240.75 |
| EINECS Number | 240-654-6 |
| melting point | 266-267 °C(lit.) |
| specific rotation | -128 º (c=5, H2O) |
| Water solubility | Soluble in water |
| Storage condition | Room temperature preservation |
What is the pharmacological action and attending function of Levamisole hydrochloride?
Levamisole hydrochloride powder is the levorotatory form of tetraimidazole, which can selectively inhibit succinate dehydrogenase in insect muscles, so that fumaric acid cannot be reduced to succinic acid, thus affecting anaerobic metabolism of insect muscles and reducing energy production. When the worm comes into contact with it, it can depolarize the neuromuscular, and the muscle will contract continuously, resulting in paralysis; The cholinergic effect of drugs is beneficial to the excretion of worms. Its activity is about 1 ~ 2 times that of tetraimidazole (racemic), but its side effects are low.
In addition, It's attending functions are:
1. Levamisole hydrochloride can be used as an anthelmintic drug. Has good curative effect on ascaris lumbricoides, hookworm, pinworm and strongyloides faecalis. Because the single dose of this product is effective, it is suitable for group therapy. The activity against adult and microfilaria of filaria bancrofti, filaria malayi and filaria onchocercaria is higher than that of ethazine, but the long-term curative effect is poor.
2. It can be an immune enhancer. It is suitable for immunotherapy of various diseases with low immune function and autoimmune diseases, such as recurrent upper respiratory tract infections, allergic asthma, allergic rhinitis, chronic hepatitis B, hepatitis B virus carriers, recurrent oral mucosal ulcers, malignant tumors, rheumatoid arthritis and wart skin diseases caused by papillomavirus infection.
3. Levamisole hydrochloride powder can be used as an antiparasitic drug. Can be used for treating ascaris lumbricoides, pinworm and hookworm.
Product Specification
| Item | Specifications | Result |
| Appearance | A white or almost white crystalline powder | Complies |
| Appearance of solution | Meets the requirements | Complies |
| Assay | 98.5%-101.0% | 99.68% |
| Ph | 3.0-4.5 | 4.1 |
| Specific optical rotation | -128 º(c=5, H2O) | Complies |
| Loss on drying | MAX 0.5% | 0.11% |
| Sulphated ash | MAX 0.5% | 0.30% |
| Heavy metals | MAX 20ppm | Complies |
| As | MAX 2ppm | Complies |
| Pb | MAX 1ppm | Complies |
| Hg | MAX 1ppm | Complies |
| Related substances | Any other impurity ≤0.1% Total impurities ≤0.3% |
Meets the requirements 0.04% |
| Conclusion: The test results are conformed to the in-house specification | ||
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Attention: It should be noted that this product is not intended for the diagnosis, treatment, cure, or prevention of any disease. Please consult your doctor and learn about available research before use. Please do not use without authorization. This compound can only be used for research purposes. The US Food and Drug Administration has not evaluated these claims.
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