Chloramphenicol is a kind of broad-spectrum antibiotic produced by Streptomyces chloridion, and natural chloramphenicol is levorotatory. Because dextrorotatory has no antibacterial effect, the curative effect of natural chloramphenicol is twice as high as that of synthetic product. Pure Chloramphenicol powder is a white or yellowish needle-like or flaky crystal, which is extremely bitter in taste, low in water solubility, stable in neutral or weakly acidic aqueous solution and easy to fail in case of alkali.
| structural formula |
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Items |
Standard |
Test Result |
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Appearance |
A white, greyish-white or yellowish-white, fine, crystalline powder or fine crystals, needles or elongated plates. |
A yellowsh-white, fine crystalline powder,needles. |
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Character |
Slightly soluble in water, freely soluble in alcohol and in propylene glycol. Its alcohol solution is dextrorotatory and its ethyl acetate solution is levorotatory. |
Qualified |
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Melting range |
Between 149℃ and 153℃ |
149.3～151.6℃ |
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Infrared absorption spectrophotometry |
IR spectrophotometry similar to which of Chloramphenicol CRS |
Qualified |
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Acidity or alkalinity |
To 0.1 g add 20 ml of carbon dioxide-free water R, shake and add 0.1 ml of bromothymol blue solution R1. Not more than 0.1 ml of 0.02 M hydrochloric acid or 0.02 M sodium hydroxide is required to change the colour of the indicator. |
Qualified |
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Specific optical rotation |
Between ﹢18.5º and ﹢20.5º |
+19.5º |
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Related substances |
Individaul impurity≤0.5% |
＜0.5% |
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Chlorides |
≤0.01% |
＜0.01% |
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Loss on drying |
≤0.3% |
0.08% |
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Sulfated ash |
≤0.1% |
0.02% |
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Assay |
98.0% to 102.0% |
100.7% |
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Microbial limit |
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Total Aerobic Microbial Count |
≤10cfu/g |
＜10CFU/g |
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Total Yeasts and Molds Count |
Absent per g |
Absent |
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Escherichia coli |
Absent per g |
Absent |
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Pseudomonas aeruginosa & staphylococcus aureus |
Absent per g |
Absent |
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Conclusion |
The product complies to EP9.0/BP2017. |
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What is the action mechanism of this product?
Chloramphenicol acts by inhibiting bacterial protein synthesis. The antibiotic chloramphenicol powder can act on the 50S subunit of bacterial ribonucleoprotein, thereby inhibiting protein synthesis. We know that the 70S ribosome in bacterial cells is the main cellular component for protein synthesis, consisting of two subunits, 50S and 30S. Pure chloramphenicol reversibly binds to the 50S subunit on the 70S ribosome of bacteria, thereby preventing the amino acid end of aminoacyl tRNA from binding to the receptor on the ribosome. In this way, the amino acid substrate cannot interact with transpeptidase, and cannot form new peptide bonds, resulting in the inability to synthesize new proteins. However, it should be noted that chloramphenicol can also bind to the 70S of human mitochondria, thereby inhibiting protein synthesis in human mitochondria. Therefore, this product may have adverse reactions to the human body, so it must be taken into account during experiments and use. Because chloramphenicol binds reversibly to the 70S ribosome, it is considered an antibacterial antibiotic. However, it can also produce bactericidal effects on certain bacteria at high drug concentrations, and even on influenza bacteria at lower concentrations.
How is the clinical application of this product?
synthomycin was widely used to treat various sensitive bacterial infections, but its clinical application has been strictly controlled because of its serious adverse reaction to hematopoietic system. Thiamphenicol and chloramphenicol are the same kind of antibiotics, only the nitro group on the benzene ring of chloramphenicol is replaced by monosulfonyl group, and its antibacterial spectrum is similar to chloramphenicol. Some countries think its curative effect is better than chloramphenicol powder, but China thinks its curative effect is not outstanding. Moreover, the concentration of this product in cerebrospinal fluid is high, and it is also often used to treat meningitis patients with poor efficacy of other drugs. However, it still needs to be noted that bacteria can be resistant to chloramphenicol in vivo and in vitro, and the number of drug-resistant strains has gradually increased in recent years, so we should be cautious when using it.
A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide Chloramphenicol powder etc. at a more favorable price. If you are interested, please leave a message.
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