What is Flunixin meglumine?
Flunixin meglumine belongs to veterinary anti-inflammatory and analgesic drugs, and has antipyretic, anti-inflammatory and analgesic effects. It can obviously improve clinical symptoms and enhance the activity of antibiotics alone or in combination with antibiotics. This product is white or off-white crystalline powder, odorless and hygroscopic.Flunixin meglumine powder is soluble in water, and almost insoluble in ethyl acetate.
| Product name |
Flunixin meglumine powder |
| CAS | 42461-84-7 |
| Molecular formula | C14H11F3N2O2.C7H17NO5 |
| Molecular weight | 491.46 |
| EINECS Number | 255-836-0 |
| melting point | 136.6-137.4 °C |
| specific rotation | -9～-12゜(D/20℃)(c=12,CH3OH) |
| Water solubility | H2O: Soluble |
| Storage condition | Room temperature preservation |
What is the attending function and pharmacological action of Flunixin meglumine ?
Attending function
It is a novel antipyretic and analgesic drug specially used for non-steroidal animals, belonging to nicotinic acid derivatives and an inhibitor of cyclooxygenase. Developed by Schering-Plough Company of the United States in 1990s, Flunixin meglumine powder has been widely used in the United States, France, Switzerland, Germany, Britain and many other countries. Veterinarians are often used to relieve the pain caused by visceral colic, muscle and bone disorder and anti-inflammation in horses. The control of acute inflammation caused by various diseases and infections in cattle, such as hoof inflammation and arthritis, can also be used for the adjuvant treatment of sow mastitis, metritis and agalactia syndrome.
Mechanism of drug action
It is an inhibitor of cyclooxygenase. By inhibiting cyclooxygenase in arachidonic acid reaction chain, it can reduce the production of inflammatory mediators such as prostaglandin and thromboxane, and by maintaining normal blood pressure, reducing the damage of vascular endothelial cells, maintaining normal blood volume, etc., Flunixin meglumine powder can prevent the increase of bronchial exudates, neutrophils and albumin aggregation in exudates caused by Escherichia coli endotoxin in respiratory diseases, and effectively relieve the body's fever, inflammation and pain. It acts quickly and generally relieves pain within 15 minutes. It is more effective than analgesic, pethidine and codeine, and it is four times more effective than phenylbutazone in treating claudication and joint swelling in horses.
Product Specification
| Item | Specifications | Result |
|
Appearance |
White to light yellow crystalline powder | Conform |
|
Assay |
99% | 99.6% |
|
Mesh Size |
100 % pass 80 mesh | Complies |
|
Ash |
≤ 5.0% | 2.85% |
|
Loss on Drying |
≤ 5.0% | 2.65% |
|
Chemical Analysis |
||
|
Heavy Metal |
≤ 10.0 mg/kg |
Complies |
|
Pb |
≤ 2.0 mg/kg |
Complies |
|
As |
≤ 1.0 mg/kg | Complies |
|
Hg |
≤ 0.1mg/kg | Complies |
|
Microbiological Analysis |
||
|
Residue of Pesticide |
Negative | Negative |
|
Total Plate Count |
≤ 1000cfu/g | Complies |
|
Yeast&Mold |
≤ 100cfu/g | Complies |
|
E.coil |
Negative |
Negative |
|
Salmonella |
Negative |
Negative |
| Conclusion: The test results are conformed to the in-house specification | ||
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Attention: It should be noted that this product is not intended for the diagnosis, treatment, cure, or prevention of any disease. Please consult your doctor and learn about available research before use. Please do not use without authorization. This compound can only be used for research purposes. The US Food and Drug Administration has not evaluated these claims.
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