Lincomycin hydrochloride is a white crystalline powder at room temperature, with slight or special odor and bitter taste. It is soluble in water or methanol, and its hydrochloride form is commonly used in feed. Pure lincomycin hydrochloride is a quick-acting antibacterial product, which has a strong inhibitory effect on sensitive bacteria that are rapidly dividing, replicating and reproducing. In veterinary clinical use, it is found that NSC 70731 can show good bacteriostatic effect if used according to the normal dosage, while Lincocin can show good bactericidal effect at high concentration.
| structural formula |
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|
Item |
Standard |
Test Results |
|
Appearance |
White powder |
Complies |
|
Identification |
IR |
Complies |
|
HPLC |
Complies |
|
|
Heavy metal |
≤10ppm |
5ppm |
|
Pb |
≤3ppm |
1.5ppm |
|
Hg |
≤0.1ppm |
0.05ppm |
|
Cd |
≤1ppm |
0.2ppm |
|
Loss on drying |
≤0.5% |
0.12 |
|
Residue on lgnition |
≤0.1% |
0.03 |
|
Single impurity |
≤0.5% |
0.12 |
|
Total impurity |
≤1.0% |
0.29 |
|
Total bacteria |
≤1000cfu/g |
<1000 |
|
Yeast and Mould |
≤100 cfu/g |
<000 |
|
E.coli/25g |
Absent |
Absent |
|
Salmonella/25g |
Absent |
Absent |
|
Assay |
≥99.0% |
99.4% |
| Conclusion： |
Conform with enterprise specification . |
What is the mechanism of action of Lincomycin Hydrochloride ?
Lincomycin hydrochloride powder is a narrow spectrum antibacterial product, and its role in clinical treatment of livestock and poultry is similar to that of tetracycline. So, lincomycin hydrochloride has a good therapeutic effect on gram-positive bacteria (including cocci); It is currently the only clinically licensed product in animal and veterinary medicine that has high efficacy against anaerobic bacteria, Staphylococcus aureus, and pneumococcal bacteria. The antibacterial mechanism of this product is similar to that of macrolide antibiotics. After digestion, circulation, and absorption, it can be distributed to the lesion site and act on the 50S subunit of sensitive bacterial ribosomes, preventing the elongation of intracellular peptide chains and inhibiting bacterial protein synthesis, thereby exerting antibacterial and bactericidal effects. It basically does not affect the daily life and growth of livestock. Moreover, It can inhibit and kill bacteria. In normal dosage use, it can show good antibacterial effects, while high concentrations show bactericidal effects.
How to better use Lincomycin Hydrochloride?
Lincomycin hydrochloride is a semi synthetic chlorinated derivative of Lincomycin, which is effective against sepsis caused by most gram-negative bacteria and certain anaerobic bacteria, as well as infections of organs, skin, and soft tissues. However, this product cannot penetrate cerebrospinal fluid and is therefore not suitable for the treatment of meningitis. Topical use is commonly used to treat pyogenic infections caused by Gram positive bacteria. However, the effect of this product is the same as that of lincomycin. Using it alone can easily lead to drug resistance and render the product ineffective. Therefore, if this product can be used in combination with erythromycin, it will have a synergistic effect. When used in combination with gentamicin, it has a synergistic effect on Staphylococcus, Streptococcus, and other bacteria. Combination with erythromycin has an antagonistic effect. The combination of aminoglycoside and peptide antibiotics can exacerbate the blocking effect on the neuromuscular junction. When used in combination with antidiarrheal products that inhibit intestinal peristalsis, it can delay the excretion of intestinal endotoxins, leading to worsening diarrhea and prolonged antidiarrheal time.
How to configure and define Lincomycin Hydrochloride ?
Lincomycin hydrochloride is a lincomycin antibacterial agent, mainly used in the clinical practice of animal and veterinary medicine for the treatment of Gram positive and anaerobic bacterial infections. Its commercialized qualified raw material is a white crystalline powder with a distinctive odor, and its 10% aqueous solution has a pH of 3.0~5.5; The commonly used preparation is also 10% lincomycin hydrochloride soluble powder.
A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
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